科普專欄–薯不揀單 - 三十秒科學–mRNA疫苗的初心（一）

目前來說，mRNA武肺疫苗在應付疫情上擔當著不可或缺的角色。704Please respect copyright.ＰＥＮＡＮＡflHbB0kAv7
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儘管如此， mRNA疫苗建立的初心，其實是在於對抗癌症方面之上，純粹是因為武肺爆發才出此變陣。704Please respect copyright.ＰＥＮＡＮＡERlWzvZDSu
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(圖2)早在1990年，科學家已嘗試分別將mRNA及DNA注射到老鼠的肌肉裡頭，然後再切除部份肌肉來檢驗其注射效果。704Please respect copyright.ＰＥＮＡＮＡA9roHwSiUD
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(圖3)注射約18小時後，科學家透過檢驗肌肉裡頭的螢光表達量來推斷注射效果。704Please respect copyright.ＰＥＮＡＮＡoffHJaskWj
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從圖中可見，若將mRNA或DNA的注射份量提升10倍，其螢光表達量亦會相繼提升10倍有多。704Please respect copyright.ＰＥＮＡＮＡTnuyOLYJ6J
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這實驗的成功，亦因而奠定了日後mRNA疫苗的發展大方向。704Please respect copyright.ＰＥＮＡＮＡi4fSdUDv4k
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下集我們將會講解 BioNTech究竟在mRNA疫苗上的設計做了甚麼的手腳，使之疫苗在免疫系統的觸發上取得重要的平衡。704Please respect copyright.ＰＥＮＡＮＡG99XbHl9e3
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Ref1:https://science.sciencemag.org/content/247/4949/1465/tab-pdf704Please respect copyright.ＰＥＮＡＮＡ1wqqglyGtv

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