科普專欄–薯不揀單 - 三十秒科學–注射mRNA疫苗後所產生的體內抗體

染上武肺及注射mRNA武肺疫苗，兩者均會使身體產生對應武肺的抗體。但兩者之間所產生的抗體數量，又會否有所分別呢?658Please respect copyright.ＰＥＮＡＮＡ7XBNEQ1auJ
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(圖2)有科學家分別對比染上武肺人士(染病111-273日後)及注射mRNA疫苗人士(0-200日後)體內對抗武肺S蛋白的抗體，發現染上武肺人士的抗體數量分佈頗為不一，可概括分成高中低(+++,++,+)三大類別。658Please respect copyright.ＰＥＮＡＮＡ87zkv1BBsF
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而注射疫苗人士的體內抗體在數量上，與武肺人士的高類別數量非常接近。658Please respect copyright.ＰＥＮＡＮＡApS9vCS0L3
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(圖3)可能是較為有趣的是，注射疫苗人士的體內抗體，有著能抵抗兩款常見導致感冒的病毒(OC43及HKU1)S蛋白質的能力。658Please respect copyright.ＰＥＮＡＮＡcUl8aZeDXD

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這有可能為注射人士帶來些許抵禦該兩隻感冒病毒入侵身體的能力，而染上武肺人士的體內抗體是否有著同樣功效，研究並沒有透露。658Please respect copyright.ＰＥＮＡＮＡxir2xsDGVe
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(圖4)研究同時亦發現，注射疫苗人士的體內抗體，大多是由不具中和力的抗體所組成(66-95%)，這到底會否引致ADE副作用，還需要一定的研究測量。658Please respect copyright.ＰＥＮＡＮＡYdvETxhoee
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而染上武肺人士的體內抗體，其具中和力及不具中和力的分佈，研究並沒有詳細透露。658Please respect copyright.ＰＥＮＡＮＡoOWsACg6kj
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Ref1:https://www.cell.com/cell/fulltext/S0092-8674(21)00706-6658Please respect copyright.ＰＥＮＡＮＡyjPB1RQg8a

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