科普專欄–薯不揀單 - 三十秒科學–細胞自噬

當細胞裡頭出現多餘或者已受損毀的物質，又或者是細胞面臨營養不足的情況，細胞便會啟動名為自噬(Autophagy)的機制，依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪，供自己能量或物質所需。822Please respect copyright.ＰＥＮＡＮＡCixl6gLX9m
822Please respect copyright.ＰＥＮＡＮＡpfJXImnHAs
822Please respect copyright.ＰＥＮＡＮＡi4nuN4p4LI
早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。822Please respect copyright.ＰＥＮＡＮＡnAQ7Khjiuc
三十秒科學–癌細胞也會自肥？822Please respect copyright.ＰＥＮＡＮＡSgQV5Cm2oC
- 分享自 LIHKG 討論區822Please respect copyright.ＰＥＮＡＮＡuPAvGLsuAN
https://lih.kg/hgfcNS822Please respect copyright.ＰＥＮＡＮＡseQtGlUro1
822Please respect copyright.ＰＥＮＡＮＡjoCYSAVsea
822Please respect copyright.ＰＥＮＡＮＡsOqsSEUCyI
(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質，使自己得以在困局下苟延殘喘。822Please respect copyright.ＰＥＮＡＮＡ1hw7ttNpV1
822Please respect copyright.ＰＥＮＡＮＡD97odhlJIT
822Please respect copyright.ＰＥＮＡＮＡwNMldxd35u
情形就如人們債務纏身而又沒有收入抵債的時候，只好變賣自己所持有的資產，化成現金抵償。822Please respect copyright.ＰＥＮＡＮＡ6tD21sfUEJ
822Please respect copyright.ＰＥＮＡＮＡU6d8X5uldv
由此可以想像，這是一道治標不治標的方法。822Please respect copyright.ＰＥＮＡＮＡIMoWxVf5AA
當長期沒有營養流入細胞，而細胞再也沒有多餘物質進行自噬的時候，細胞便會啟動自行滅亡的機制。822Please respect copyright.ＰＥＮＡＮＡkNwPBSh07N
822Please respect copyright.ＰＥＮＡＮＡTRRyvsjpkA
822Please respect copyright.ＰＥＮＡＮＡS7poC6tVtC
(圖3)如果催谷癌細胞不斷進行自噬作用的話，促使它們啟動自行滅亡的機制，那豈不是殺滅它們的一道妙計?822Please respect copyright.ＰＥＮＡＮＡiBm2v20JnW
822Please respect copyright.ＰＥＮＡＮＡckDvKE4Use
822Please respect copyright.ＰＥＮＡＮＡWVbKz4nHc9
很遺憾地，各款癌細胞對於自噬作用的依賴及抗性均有所不同，難以就此單一針對自噬作用來消滅癌細胞。822Please respect copyright.ＰＥＮＡＮＡBNefOsbWtO
822Please respect copyright.ＰＥＮＡＮＡ6Qq8eWgQ0M
暫時較為統一的發現是，大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。822Please respect copyright.ＰＥＮＡＮＡO9ooq605Ho
822Please respect copyright.ＰＥＮＡＮＡywYJQ2Q2ff
在實驗室細胞模型及老鼠實驗中，若果對胰臟癌細胞使用抑制自噬作用的藥物，不但改變它們的新陳代謝，且可減慢癌細胞的生長速度，非常之有潛質成為對抗胰臟癌的其中一手段。822Please respect copyright.ＰＥＮＡＮＡPraSWzhMSn
822Please respect copyright.ＰＥＮＡＮＡ2Zt9uWAFc3
822Please respect copyright.ＰＥＮＡＮＡjVspBPLWnv
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。822Please respect copyright.ＰＥＮＡＮＡGiTIA8Yqsa
822Please respect copyright.ＰＥＮＡＮＡ2zmbsKVePj
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc822Please respect copyright.ＰＥＮＡＮＡobEW93g7a9
822Please respect copyright.ＰＥＮＡＮＡ1ES1MJZkqT
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。822Please respect copyright.ＰＥＮＡＮＡumkYwxRwEF
822Please respect copyright.ＰＥＮＡＮＡVm4NS8iGB8
Link:822Please respect copyright.ＰＥＮＡＮＡJKmgXeBb6a
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio822Please respect copyright.ＰＥＮＡＮＡfegNlNOg0o
822Please respect copyright.ＰＥＮＡＮＡ0JHc1N2JQS
822Please respect copyright.ＰＥＮＡＮＡMP9jnAL5X9
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。822Please respect copyright.ＰＥＮＡＮＡGJdfpKwbpL
822Please respect copyright.ＰＥＮＡＮＡHGE166vwb5
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/822Please respect copyright.ＰＥＮＡＮＡ7YhMtlwr60
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long

ns216.73.216.217da2

Reading Theme:

Font Size:

Line Spacing:

Paragraph Spacing:

Load the next issue automatically