科普專欄–薯不揀單 - 三十秒科學–癌細胞也會自肥？

從圖中可見，癌細胞所在的環境非常複雜。508Please respect copyright.ＰＥＮＡＮＡEdydI3P16n
癌細胞附近不只有著各種細胞，其就近的血管大多處於參差不齊的狀態，導致營養及氧氣難以順利到達癌細胞裡頭。508Please respect copyright.ＰＥＮＡＮＡ1itqanbTX4
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在這種「逆境」之中，癌細胞究竟有何手段求生呢?508Please respect copyright.ＰＥＮＡＮＡtAMZyru4xy
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(圖2)在導管胰腺癌中，科學家發現癌細胞的所在位置含有大量名為CAM的細胞。508Please respect copyright.ＰＥＮＡＮＡJBwDR37LW5
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經一系列的研究後，科學家發現這些細胞竟然是協助癌細胞長大的好幫手。508Please respect copyright.ＰＥＮＡＮＡB3170V8njI
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(圖3)圖中為癌細胞如何利用周遭的CAM細胞供養自己的機制。508Please respect copyright.ＰＥＮＡＮＡjuqYpV9wmD

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在營養短缺的環境下，癌細胞迫使周遭的細胞分解蛋白質供自己所用，從而渡過難關及繼續在逆境中成長。508Please respect copyright.ＰＥＮＡＮＡI8q8QdKtUt
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在老鼠的動物模型中，若然抑制CAM細胞進行自噬作用，癌細胞的體積的確是有所縮小，得以證實癌細胞會用盡身邊的一事一物從而壯大自己，在先天資源短缺的環境下亦能「自肥」。508Please respect copyright.ＰＥＮＡＮＡGecQTXNRB4
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Ref1:https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30102-2508Please respect copyright.ＰＥＮＡＮＡDXcqk6r9AB
Ref2:https://pubmed.ncbi.nlm.nih.gov/27509858/508Please respect copyright.ＰＥＮＡＮＡXumQq9SOmB

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