減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。814Please respect copyright.ＰＥＮＡＮＡChwwzLsjO7
814Please respect copyright.ＰＥＮＡＮＡfebeBkbVvX
814Please respect copyright.ＰＥＮＡＮＡboaB6CkVBG
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，814Please respect copyright.ＰＥＮＡＮＡtDhQik9EUw
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。814Please respect copyright.ＰＥＮＡＮＡ4g4aBEicXi
814Please respect copyright.ＰＥＮＡＮＡzkoFlgckJU
814Please respect copyright.ＰＥＮＡＮＡ952cXaP2yE
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。814Please respect copyright.ＰＥＮＡＮＡbSX7J6Jdm6
814Please respect copyright.ＰＥＮＡＮＡjKrmCmH1Du
814Please respect copyright.ＰＥＮＡＮＡ4T21YzQUWA
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。814Please respect copyright.ＰＥＮＡＮＡr4dhJK1DxU
814Please respect copyright.ＰＥＮＡＮＡSRNdxtBhrU
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。814Please respect copyright.ＰＥＮＡＮＡIlRCSLGkGe
814Please respect copyright.ＰＥＮＡＮＡwciI4Ww5CU
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。814Please respect copyright.ＰＥＮＡＮＡ7d1tPKt1ZE
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。814Please respect copyright.ＰＥＮＡＮＡeNWTgI52DT
814Please respect copyright.ＰＥＮＡＮＡ6qmvaB7689
814Please respect copyright.ＰＥＮＡＮＡuBMrPTlGUJ
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。814Please respect copyright.ＰＥＮＡＮＡ029DMhWaPp
814Please respect copyright.ＰＥＮＡＮＡTrPY5Z8Wnm
814Please respect copyright.ＰＥＮＡＮＡQFiaJ2Cfjs
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。814Please respect copyright.ＰＥＮＡＮＡyYn1IlSLPS
814Please respect copyright.ＰＥＮＡＮＡaDg2x94ZAL
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。814Please respect copyright.ＰＥＮＡＮＡTVOTivNIsR
814Please respect copyright.ＰＥＮＡＮＡkDo2VMCYeq
814Please respect copyright.ＰＥＮＡＮＡeR9Zf3yBwV
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。814Please respect copyright.ＰＥＮＡＮＡTulDfPBxVb
814Please respect copyright.ＰＥＮＡＮＡnjSUZT7xeO
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc814Please respect copyright.ＰＥＮＡＮＡY4z9NlLAon
814Please respect copyright.ＰＥＮＡＮＡmIZTG9lH6N
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。814Please respect copyright.ＰＥＮＡＮＡXPNuAFF1QC
814Please respect copyright.ＰＥＮＡＮＡjB8pQv25t5
Link:814Please respect copyright.ＰＥＮＡＮＡRNxOGSuxEM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio814Please respect copyright.ＰＥＮＡＮＡZKNeL9ZZLb
814Please respect copyright.ＰＥＮＡＮＡaJrcFzKSSx
814Please respect copyright.ＰＥＮＡＮＡcmidk3vBvk
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。814Please respect copyright.ＰＥＮＡＮＡOO7sICCvea
814Please respect copyright.ＰＥＮＡＮＡtE7Bxnbi0X
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/814Please respect copyright.ＰＥＮＡＮＡz1eVlAj8dd
Ref2:https://www.sciencedirect.com/science/article/pii/S2212877821000466814Please respect copyright.ＰＥＮＡＮＡajXH2rQJ4e
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/814Please respect copyright.ＰＥＮＡＮＡENvUvse08F
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/814Please respect copyright.ＰＥＮＡＮＡWLXKqXB4ES
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/814Please respect copyright.ＰＥＮＡＮＡ4clWpIQDLr
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科普專欄–薯不揀單
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科普專欄–薯不揀單
Author:
薯仔聞茱莉
薯仔聞茱莉
ISSUE #232
三十秒科學–利用藥物抑制食慾以作對抗癡肥
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