減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1115Please respect copyright.ＰＥＮＡＮＡc1tO7DCqt5
1115Please respect copyright.ＰＥＮＡＮＡNMvfCz6f6U
1115Please respect copyright.ＰＥＮＡＮＡRfJ3FWxz61
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1115Please respect copyright.ＰＥＮＡＮＡiZ0Q1v55WY
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1115Please respect copyright.ＰＥＮＡＮＡTZGfgpKang
1115Please respect copyright.ＰＥＮＡＮＡh5s7Xwkcib
1115Please respect copyright.ＰＥＮＡＮＡu4oCOG2Guv
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1115Please respect copyright.ＰＥＮＡＮＡa2BekOGyT5
1115Please respect copyright.ＰＥＮＡＮＡSMqTDiMvQh
1115Please respect copyright.ＰＥＮＡＮＡPICd9k6BiV
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1115Please respect copyright.ＰＥＮＡＮＡyxjF3mVB7Z
1115Please respect copyright.ＰＥＮＡＮＡyJJCdZd62S
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1115Please respect copyright.ＰＥＮＡＮＡZgZHSbq6Kn
1115Please respect copyright.ＰＥＮＡＮＡSa9PVUYK0B
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1115Please respect copyright.ＰＥＮＡＮＡaDRsHoTknj
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1115Please respect copyright.ＰＥＮＡＮＡieQuUaVHmQ
1115Please respect copyright.ＰＥＮＡＮＡDjQUOpLkXO
1115Please respect copyright.ＰＥＮＡＮＡjD91YdVcI8
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1115Please respect copyright.ＰＥＮＡＮＡnlM4p9myMR
1115Please respect copyright.ＰＥＮＡＮＡdJhJpfzXsx
1115Please respect copyright.ＰＥＮＡＮＡz7Q08Zrc8Z
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1115Please respect copyright.ＰＥＮＡＮＡWEgpAgRZma
1115Please respect copyright.ＰＥＮＡＮＡyag8rQ7LHL
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1115Please respect copyright.ＰＥＮＡＮＡrelkIhUMEw
1115Please respect copyright.ＰＥＮＡＮＡlnOROemway
1115Please respect copyright.ＰＥＮＡＮＡBvgCPFpQAO
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1115Please respect copyright.ＰＥＮＡＮＡ7DbCss15DB
1115Please respect copyright.ＰＥＮＡＮＡJwAVopre2Q
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1115Please respect copyright.ＰＥＮＡＮＡgItiKHsaze
1115Please respect copyright.ＰＥＮＡＮＡXKEkeDS4Ev
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1115Please respect copyright.ＰＥＮＡＮＡQwtf4Vk1Wm
1115Please respect copyright.ＰＥＮＡＮＡAqvVecyDBP
Link:1115Please respect copyright.ＰＥＮＡＮＡu7AdAlR99q
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1115Please respect copyright.ＰＥＮＡＮＡVuRq6DkFSg
1115Please respect copyright.ＰＥＮＡＮＡuc7QAorGkP
1115Please respect copyright.ＰＥＮＡＮＡh5bkC4fJt3
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1115Please respect copyright.ＰＥＮＡＮＡMshssXf9Ph
1115Please respect copyright.ＰＥＮＡＮＡ0yAu49eJNx
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1115Please respect copyright.ＰＥＮＡＮＡLJv8HoFohQ
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661115Please respect copyright.ＰＥＮＡＮＡ2IQzrSMip9
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1115Please respect copyright.ＰＥＮＡＮＡhWA6fjZgpq
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1115Please respect copyright.ＰＥＮＡＮＡ2QjclxGfCs
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1115Please respect copyright.ＰＥＮＡＮＡp0oRpqfHwI
8964 copyright protection1111ＰＥＮＡＮＡ03kfZoXXt4 維尼

216.73.216.32