減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1292Please respect copyright.ＰＥＮＡＮＡoFO5mUcQAw
1292Please respect copyright.ＰＥＮＡＮＡ2gdF6Chbha
1292Please respect copyright.ＰＥＮＡＮＡG7uZk9D6Ea
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1292Please respect copyright.ＰＥＮＡＮＡDd6Mtdu2Ck
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1292Please respect copyright.ＰＥＮＡＮＡTQcnvmmjjZ
1292Please respect copyright.ＰＥＮＡＮＡyJkRuKNvr9
1292Please respect copyright.ＰＥＮＡＮＡ1UNGimJkdT
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1292Please respect copyright.ＰＥＮＡＮＡDReWdP6cY4
1292Please respect copyright.ＰＥＮＡＮＡfpGsITUpQv
1292Please respect copyright.ＰＥＮＡＮＡ2iLmHrEwii
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1292Please respect copyright.ＰＥＮＡＮＡ2FM5SiDro3
1292Please respect copyright.ＰＥＮＡＮＡeZS8D2XPL2
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1292Please respect copyright.ＰＥＮＡＮＡaCsHcE8Dm8
1292Please respect copyright.ＰＥＮＡＮＡin7P8Lpwaw
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1292Please respect copyright.ＰＥＮＡＮＡC9KFL7HC2Q
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1292Please respect copyright.ＰＥＮＡＮＡB1cOYVRutb
1292Please respect copyright.ＰＥＮＡＮＡl4ZGpYg8m1
1292Please respect copyright.ＰＥＮＡＮＡc5Y5bma19F
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1292Please respect copyright.ＰＥＮＡＮＡowBg1slDPU
1292Please respect copyright.ＰＥＮＡＮＡVE8wSdeKIt
1292Please respect copyright.ＰＥＮＡＮＡBGLYwx3fsd
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1292Please respect copyright.ＰＥＮＡＮＡCrECixhds0
1292Please respect copyright.ＰＥＮＡＮＡ23Rht3BAEy
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1292Please respect copyright.ＰＥＮＡＮＡtyi2tecjnC
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1292Please respect copyright.ＰＥＮＡＮＡGRH9WUSeYk
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1292Please respect copyright.ＰＥＮＡＮＡjYrvI5y3pT
1292Please respect copyright.ＰＥＮＡＮＡEwZii9p1hv
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1292Please respect copyright.ＰＥＮＡＮＡAVLCFXs6lT
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Link:1292Please respect copyright.ＰＥＮＡＮＡuEeXTTYSyc
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1292Please respect copyright.ＰＥＮＡＮＡJXohF213ac
1292Please respect copyright.ＰＥＮＡＮＡjULAl9sIHC
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1292Please respect copyright.ＰＥＮＡＮＡ6Zo5WDECFz
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1292Please respect copyright.ＰＥＮＡＮＡrGVOPciz4J
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661292Please respect copyright.ＰＥＮＡＮＡKzfnEhNeh9
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1292Please respect copyright.ＰＥＮＡＮＡdpVaEE0o5h
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1292Please respect copyright.ＰＥＮＡＮＡECoZ9pqjfD
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1292Please respect copyright.ＰＥＮＡＮＡFRSzipnI5Z
1234 copyright protection1288ＰＥＮＡＮＡEIc48omrMJ 尼

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