科普專欄–薯不揀單 - 三十秒科學–利用藥物抑制食慾以作對抗癡肥

減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1083Please respect copyright.ＰＥＮＡＮＡFLDMoYQ6LR
1083Please respect copyright.ＰＥＮＡＮＡJ9TAdY5CZh
1083Please respect copyright.ＰＥＮＡＮＡW7ID6pwkQT
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1083Please respect copyright.ＰＥＮＡＮＡyLqPX6hrh1
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1083Please respect copyright.ＰＥＮＡＮＡye0i64EJiP
1083Please respect copyright.ＰＥＮＡＮＡC6TXx4ZW9T
1083Please respect copyright.ＰＥＮＡＮＡSgXJndtpG5
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1083Please respect copyright.ＰＥＮＡＮＡWlMSXVzsoj
1083Please respect copyright.ＰＥＮＡＮＡktWtrR2hSU
1083Please respect copyright.ＰＥＮＡＮＡqFtlB8LXdy
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1083Please respect copyright.ＰＥＮＡＮＡ6buF7sNK6b
1083Please respect copyright.ＰＥＮＡＮＡNxYIm8YBgo
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1083Please respect copyright.ＰＥＮＡＮＡTedmPf7jwj
1083Please respect copyright.ＰＥＮＡＮＡQ2iBl2Q560
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1083Please respect copyright.ＰＥＮＡＮＡdZ49Loy7Op
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1083Please respect copyright.ＰＥＮＡＮＡkIwLDqi5sU
1083Please respect copyright.ＰＥＮＡＮＡqRmu8NDLmo
1083Please respect copyright.ＰＥＮＡＮＡFbIvUyhjUI
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1083Please respect copyright.ＰＥＮＡＮＡHDRPsUiDuW
1083Please respect copyright.ＰＥＮＡＮＡLN0cxlv1n7
1083Please respect copyright.ＰＥＮＡＮＡ5Ieyb7rO9e
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1083Please respect copyright.ＰＥＮＡＮＡI6vsQ3tU9C
1083Please respect copyright.ＰＥＮＡＮＡ6hZOHSM4Qw
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1083Please respect copyright.ＰＥＮＡＮＡcmpbcMsQBX
1083Please respect copyright.ＰＥＮＡＮＡZdUbJ9VPaP
1083Please respect copyright.ＰＥＮＡＮＡlJ8NCzIi8g
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1083Please respect copyright.ＰＥＮＡＮＡx9yxdn3S8X
1083Please respect copyright.ＰＥＮＡＮＡeEiDmQl3FJ
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1083Please respect copyright.ＰＥＮＡＮＡW6NNGbBNrr
1083Please respect copyright.ＰＥＮＡＮＡLx9O2lnEvi
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1083Please respect copyright.ＰＥＮＡＮＡ5kbzO2EXdO
1083Please respect copyright.ＰＥＮＡＮＡtHVggteT8n
Link:1083Please respect copyright.ＰＥＮＡＮＡswe3Y0qKwe
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1083Please respect copyright.ＰＥＮＡＮＡtbNUdVxMLN
1083Please respect copyright.ＰＥＮＡＮＡHuANofU2tc
1083Please respect copyright.ＰＥＮＡＮＡJqp9bHSb35
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1083Please respect copyright.ＰＥＮＡＮＡdvhoKORmKD
1083Please respect copyright.ＰＥＮＡＮＡ23snqhzSYh
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1083Please respect copyright.ＰＥＮＡＮＡp9pWbokwhq
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661083Please respect copyright.ＰＥＮＡＮＡV9cqzqr4IY
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1083Please respect copyright.ＰＥＮＡＮＡbvRVRhqiH1
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1083Please respect copyright.ＰＥＮＡＮＡ5f7014sHXu
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1083Please respect copyright.ＰＥＮＡＮＡASgfL8Av2P

ns216.73.217.1da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章