我們身體的各部份均是由細胞組成,眼睛晶片也自當然不例外。771Please respect copyright.PENANANi5JYrvJlU
但細胞裡頭有著各式各樣的細胞器官,例如負責製造能源的粒線體(mitochondria)、收藏DNA的細胞核(nucleus)等,它們顯然並不是透明的。771Please respect copyright.PENANAwKayFvddYi771Please respect copyright.PENANACkXP4AUdRy
究竟身體有甚麼方法可以製造透明且能讓光線通過的眼鏡晶片呢?771Please respect copyright.PENANA0QzMXR7qOy
771Please respect copyright.PENANAL6QcHxu8TO
771Please respect copyright.PENANAjgwzJMdtb7
771Please respect copyright.PENANAriBDRxZtEH
(圖2)答案很簡單,就是把那些細胞器官通通摧毀。771Please respect copyright.PENANAUEhGCfgLSX771Please respect copyright.PENANAkLKIUveQ9m
771Please respect copyright.PENANAUGV4FigEu4
從圖中可見,晶片的外圍有著表皮細胞(Epithelial cells)以及纖維細胞(Fibre cells),唯獨是中間區域的細胞,它們的細胞器官均接近得消失得一乾二淨。771Please respect copyright.PENANAAgJ7rs6szQ
771Please respect copyright.PENANAFI4GwsMReu
771Please respect copyright.PENANAVvveKh4FU6
(圖3)有科學家利用班馬魚作動物模型,並將兩款細胞器官分別染成綠色及紅色。771Please respect copyright.PENANA8W76NWRm5V771Please respect copyright.PENANASliwMgokjI
771Please respect copyright.PENANAO9WdEiR7XJ
從圖中可見,直至班馬魚受精後約59小時左右,綠色及紅色均分別清晰可見及有著其獨特的分佈,表示兩款細胞器官非常健在。771Please respect copyright.PENANAatVauKF420
但在約60小時打後,紅色和綠色開始有著衰退的現象,亦即表示細胞器官開始逐漸被受摧毀。771Please respect copyright.PENANAEaYq7qA6su
771Please respect copyright.PENANAe4XVzBiwLX
771Please respect copyright.PENANAihFQ6TvgJZ
(圖4)找出眼睛晶片的細胞器官被受摧毀的時段後,研究人員便著手進行一系列的實驗,771Please respect copyright.PENANAQO32RJDZdS
並發現名為plaat的蛋白質負責在細胞器官的外膜進行破壞,因而引發細胞器官摧毀的過程。771Please respect copyright.PENANA9YMZjZw4rM771Please respect copyright.PENANAn8PQeQu3h8
771Please respect copyright.PENANA2tN3o08g8F
圖中為班馬魚的眼睛晶片,可見因為缺乏plaat蛋白質的緣故,細胞器官沒能完整摧毀,其晶片亦變得相對上混濁及不透光,影像亦較為不清晰。771Please respect copyright.PENANAsjlh8pjuCx
771Please respect copyright.PENANAQQJn86ORRX
771Please respect copyright.PENANA5P1y7wkGkg
(圖5)除班馬魚外,研究人員亦有利用老鼠進行實驗。771Please respect copyright.PENANAIMhfY8OsNQ771Please respect copyright.PENANADrFoYRClM4
771Please respect copyright.PENANANe5OsRWbgZ
跟班馬魚一樣,缺乏plaat蛋白質的老鼠眼睛晶片變得混濁及不透光,並影響視線。771Please respect copyright.PENANAPUYvCWADx4
771Please respect copyright.PENANAhh0OdKEhgq
771Please respect copyright.PENANAPWtU6tQgPo
771Please respect copyright.PENANADawvwNvxVW
771Please respect copyright.PENANA2BM0ZtQevS
771Please respect copyright.PENANAzVIX0C7MjK
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。771Please respect copyright.PENANAYNBHPFfT08
771Please respect copyright.PENANAJVjIPL6Psx
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc771Please respect copyright.PENANABPOaYntTEv
771Please respect copyright.PENANARDUu4unNX9
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。771Please respect copyright.PENANAo94dtpsHNg
771Please respect copyright.PENANAMCmscQalDk
Link:771Please respect copyright.PENANAOo7vrKmlif
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio771Please respect copyright.PENANAoQ7sahI1wK
771Please respect copyright.PENANAa8GU8QuwrY
771Please respect copyright.PENANAwPCM35zDhf
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。771Please respect copyright.PENANAOow9ggEwdr
771Please respect copyright.PENANARgCMf21ycb
Ref1:https://www.nature.com/articles/s41586-021-03439-w771Please respect copyright.PENANAlzHnfHBUFq
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科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #205
三十秒科學–雪亮的眼睛
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