科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失(4)

要理解為何癌症會導致肌肉萎縮，其中的一道辦法就是對比萎縮肌肉與正常肌肉有甚麼分別，再以推敲其相關的機制。978Please respect copyright.ＰＥＮＡＮＡZhrts3Jgm2
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(圖2)研究發現，患癌老鼠的萎縮肌肉中，其名為ZIP14的蛋白質含量特別高企，且在患癌的老鼠但其肌肉並沒有萎縮的情況下， ZIP14的蛋白質含量並沒有顯著提升。978Please respect copyright.ＰＥＮＡＮＡnJAKhyy9nK
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(圖3)ZIP14蛋白質的主要作用是把鋅 (Zinc)輸送到細胞裡頭。978Please respect copyright.ＰＥＮＡＮＡAxRSvz3M7h
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科學家量度因癌症而導致萎縮的肌肉，發現肌肉的鋅 (Zinc)含量的確是比正常肌肉的為多，與其ZIP14蛋白質含量不謀而合。978Please respect copyright.ＰＥＮＡＮＡVAJLuElBxK
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(圖4)利用基因工程移除ZIP14蛋白質的話，可以見得到患癌老鼠的肌肉細胞橫切面並沒有顯著的減少。978Please respect copyright.ＰＥＮＡＮＡcBcwcY9Vxl
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再作一系列的實驗後，科學家推斷當癌細胞所釋出的TGFa/b物質到達肌肉位置後，便會引起肌肉ZIP14蛋白質含量上升，因而引起肌肉萎縮。978Please respect copyright.ＰＥＮＡＮＡcEG6ZDFPth
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科學家們現正研究如何針對ZIP14蛋白質來抑制癌症所引致的肌肉萎縮，結果適目而待。978Please respect copyright.ＰＥＮＡＮＡgBFFAJAo1z
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Ref1:https://pubmed.ncbi.nlm.nih.gov/29875463/978Please respect copyright.ＰＥＮＡＮＡkIeDEcaxaX

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