科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失(4)

要理解為何癌症會導致肌肉萎縮，其中的一道辦法就是對比萎縮肌肉與正常肌肉有甚麼分別，再以推敲其相關的機制。739Please respect copyright.ＰＥＮＡＮＡ624YYErHot
739Please respect copyright.ＰＥＮＡＮＡMjjYaJMqym
739Please respect copyright.ＰＥＮＡＮＡ1eXLocPXn3
(圖2)研究發現，患癌老鼠的萎縮肌肉中，其名為ZIP14的蛋白質含量特別高企，且在患癌的老鼠但其肌肉並沒有萎縮的情況下， ZIP14的蛋白質含量並沒有顯著提升。739Please respect copyright.ＰＥＮＡＮＡGr3mCzBq1x
739Please respect copyright.ＰＥＮＡＮＡKID8adTD2e
739Please respect copyright.ＰＥＮＡＮＡKPaUIWveGY
(圖3)ZIP14蛋白質的主要作用是把鋅 (Zinc)輸送到細胞裡頭。739Please respect copyright.ＰＥＮＡＮＡgCxm5Q68vz
739Please respect copyright.ＰＥＮＡＮＡIRpuL6Nr3W
739Please respect copyright.ＰＥＮＡＮＡEMcBNofq46
科學家量度因癌症而導致萎縮的肌肉，發現肌肉的鋅 (Zinc)含量的確是比正常肌肉的為多，與其ZIP14蛋白質含量不謀而合。739Please respect copyright.ＰＥＮＡＮＡG5BW7nVO8W
739Please respect copyright.ＰＥＮＡＮＡlJE0ZIS98m
739Please respect copyright.ＰＥＮＡＮＡLM9KGuyzgW
(圖4)利用基因工程移除ZIP14蛋白質的話，可以見得到患癌老鼠的肌肉細胞橫切面並沒有顯著的減少。739Please respect copyright.ＰＥＮＡＮＡWZ54spzWEJ
739Please respect copyright.ＰＥＮＡＮＡV6AZVDz0UZ
739Please respect copyright.ＰＥＮＡＮＡfa01UmJb2B
再作一系列的實驗後，科學家推斷當癌細胞所釋出的TGFa/b物質到達肌肉位置後，便會引起肌肉ZIP14蛋白質含量上升，因而引起肌肉萎縮。739Please respect copyright.ＰＥＮＡＮＡpuMC6xrxII
739Please respect copyright.ＰＥＮＡＮＡp5pntTIwvL
科學家們現正研究如何針對ZIP14蛋白質來抑制癌症所引致的肌肉萎縮，結果適目而待。739Please respect copyright.ＰＥＮＡＮＡcCP9NXWqEb
739Please respect copyright.ＰＥＮＡＮＡXo2M2cJe9Q
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。739Please respect copyright.ＰＥＮＡＮＡKLeuIQGmR5
739Please respect copyright.ＰＥＮＡＮＡJs8EEqSZNF
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc739Please respect copyright.ＰＥＮＡＮＡH52na1u9no
739Please respect copyright.ＰＥＮＡＮＡtG1ZjfjsER
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。739Please respect copyright.ＰＥＮＡＮＡUDS1BtU9nx
739Please respect copyright.ＰＥＮＡＮＡRY459RIh1b
Link:739Please respect copyright.ＰＥＮＡＮＡpIDQEWcLqU
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio739Please respect copyright.ＰＥＮＡＮＡy4eDyK1H1T
739Please respect copyright.ＰＥＮＡＮＡ5ANjyqCI3D
739Please respect copyright.ＰＥＮＡＮＡishfrKEMS9
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。739Please respect copyright.ＰＥＮＡＮＡEZ5yWTt84c
739Please respect copyright.ＰＥＮＡＮＡq7AGZL3MOV
Ref1:https://pubmed.ncbi.nlm.nih.gov/29875463/739Please respect copyright.ＰＥＮＡＮＡqWf3mVuYBx

ns18.119.29.162da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章