科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失(3)

癌細胞從原位轉移到另一器官，亦即是Metastasis，是癌病患者主要的死因。440Please respect copyright.ＰＥＮＡＮＡhCM9KMMwVB
440Please respect copyright.ＰＥＮＡＮＡXxG2plgMEY
440Please respect copyright.ＰＥＮＡＮＡzQuzj3hXqr
「有趣的是」，癌細胞雖近乎不會轉移到肌肉位置裡頭，但卻能從遠處釋放物質，經由血管抵達肌肉位置，催使肌肉萎縮，亦即是癌症惡病質(cancer cachexia)。440Please respect copyright.ＰＥＮＡＮＡVBGdDtDm4Y
440Please respect copyright.ＰＥＮＡＮＡ0lZosQHDZZ
(圖2)肌肉萎縮不但之令病人變得虛弱，難以接近正常劑量的化療，更為致命的是，當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候，病人便會因呼吸困難等問題而逝死。440Please respect copyright.ＰＥＮＡＮＡE8UAqQkQJU
440Please respect copyright.ＰＥＮＡＮＡ8YAe4Hm0IK
440Please respect copyright.ＰＥＮＡＮＡLkYrjoWf9D
早在1858年已有科學家指出cancer cachexia的存在，但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。440Please respect copyright.ＰＥＮＡＮＡfTSBEnW76k
440Please respect copyright.ＰＥＮＡＮＡ6DtZMV6DJR
(圖3)現時有不少臨床研究希望可以制衡cancer cachexia，普遍均是從營養方面入手。440Please respect copyright.ＰＥＮＡＮＡvZjuIzCPsX
440Please respect copyright.ＰＥＮＡＮＡQbanfg6YRI
440Please respect copyright.ＰＥＮＡＮＡxzLhOKtDBH
但結果大多數是只能夠增加病人的脂肪組織，而沒能夠填補已萎縮的肌肉。440Please respect copyright.ＰＥＮＡＮＡEcpSMsNzSZ
440Please respect copyright.ＰＥＮＡＮＡvuYA9TVHrG
有一點值得注意的是，肌肉細胞並非是死去，純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快，因而形成萎縮。440Please respect copyright.ＰＥＮＡＮＡpbEApzy3Hm
440Please respect copyright.ＰＥＮＡＮＡpLRbf7tKf8
440Please respect copyright.ＰＥＮＡＮＡ8E5ZGnsLIt
(圖4)從研究Cancer cachexia的老鼠模型中可以看到，患癌的老鼠不但更為細小，其手腕的握力度亦有所下降。440Please respect copyright.ＰＥＮＡＮＡ2m4BgYXGkl
440Please respect copyright.ＰＥＮＡＮＡbd0grhhNf2
440Please respect copyright.ＰＥＮＡＮＡErPIYKlpre
觀察肌肉細胞橫切面的面積時，亦可以看到肌肉細胞的面積明顯有所縮細。440Please respect copyright.ＰＥＮＡＮＡspjooPX78y
440Please respect copyright.ＰＥＮＡＮＡd82GTJjolz
440Please respect copyright.ＰＥＮＡＮＡBvySbfUyfY
440Please respect copyright.ＰＥＮＡＮＡvA0HjZmaNc
下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。440Please respect copyright.ＰＥＮＡＮＡytHCZ9EQWY
440Please respect copyright.ＰＥＮＡＮＡVPwro4pBES
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。440Please respect copyright.ＰＥＮＡＮＡKzV3vquMXE
440Please respect copyright.ＰＥＮＡＮＡ7XmJmpaEX9
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc440Please respect copyright.ＰＥＮＡＮＡBwRoCjSr2o
440Please respect copyright.ＰＥＮＡＮＡFeeEXSp3UH
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。440Please respect copyright.ＰＥＮＡＮＡzHjiS0Vzol
440Please respect copyright.ＰＥＮＡＮＡYAsZ9AH0ku
Link:440Please respect copyright.ＰＥＮＡＮＡfvWCj3dSKv
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio440Please respect copyright.ＰＥＮＡＮＡUwrMkMNtdR
440Please respect copyright.ＰＥＮＡＮＡwTBqvdfBkP
440Please respect copyright.ＰＥＮＡＮＡFIm60PO6WO
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。440Please respect copyright.ＰＥＮＡＮＡany3Uufprg
440Please respect copyright.ＰＥＮＡＮＡpq4KKB72Gp
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/440Please respect copyright.ＰＥＮＡＮＡC7skuhBCmn

ns3.144.231.11da2

Reading Theme:

Font Size:

Line Spacing:

Paragraph Spacing:

Load the next issue automatically