科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失(3)

癌細胞從原位轉移到另一器官，亦即是Metastasis，是癌病患者主要的死因。461Please respect copyright.ＰＥＮＡＮＡYK70qiTR9d
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「有趣的是」，癌細胞雖近乎不會轉移到肌肉位置裡頭，但卻能從遠處釋放物質，經由血管抵達肌肉位置，催使肌肉萎縮，亦即是癌症惡病質(cancer cachexia)。461Please respect copyright.ＰＥＮＡＮＡ5CXPCTVshA
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(圖2)肌肉萎縮不但之令病人變得虛弱，難以接近正常劑量的化療，更為致命的是，當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候，病人便會因呼吸困難等問題而逝死。461Please respect copyright.ＰＥＮＡＮＡ8z0Mk7gkoT
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早在1858年已有科學家指出cancer cachexia的存在，但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。461Please respect copyright.ＰＥＮＡＮＡ5NSO0DfgnP
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(圖3)現時有不少臨床研究希望可以制衡cancer cachexia，普遍均是從營養方面入手。461Please respect copyright.ＰＥＮＡＮＡFwnM56wt4I
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但結果大多數是只能夠增加病人的脂肪組織，而沒能夠填補已萎縮的肌肉。461Please respect copyright.ＰＥＮＡＮＡmnBLEiA3KD
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有一點值得注意的是，肌肉細胞並非是死去，純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快，因而形成萎縮。461Please respect copyright.ＰＥＮＡＮＡ44h7G0Qgvx
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(圖4)從研究Cancer cachexia的老鼠模型中可以看到，患癌的老鼠不但更為細小，其手腕的握力度亦有所下降。461Please respect copyright.ＰＥＮＡＮＡJfJTbSqmZ3
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觀察肌肉細胞橫切面的面積時，亦可以看到肌肉細胞的面積明顯有所縮細。461Please respect copyright.ＰＥＮＡＮＡfqqfEcwBEo
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下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。461Please respect copyright.ＰＥＮＡＮＡ3hjrrVY3kC
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。461Please respect copyright.ＰＥＮＡＮＡPh1Yikw2EZ
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc461Please respect copyright.ＰＥＮＡＮＡ4WlKb138oY
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。461Please respect copyright.ＰＥＮＡＮＡI2S0iP6NOI
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio461Please respect copyright.ＰＥＮＡＮＡktrgawnm64
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。461Please respect copyright.ＰＥＮＡＮＡ35qROvXvBE
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Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/461Please respect copyright.ＰＥＮＡＮＡLrfdtt9rny

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