科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失(2)

此為上集的補充篇:三十秒科學–癌症所導致的體重流失418Please respect copyright.ＰＥＮＡＮＡUGfYKu51AE
https://lih.kg/2397914418Please respect copyright.ＰＥＮＡＮＡn8BWTE5LSp
418Please respect copyright.ＰＥＮＡＮＡHCRoxfzCss
癌症惡病質(cancer cachexia)泛指因癌症而導致的體重流失，大部份情況下主要是由喪失肌肉所致，並沒法依靠進食來填補其喪失。418Please respect copyright.ＰＥＮＡＮＡGRnvcBQIoA
418Please respect copyright.ＰＥＮＡＮＡ2j4wy3CO6G
418Please respect copyright.ＰＥＮＡＮＡlBvhcc1O6k
在眾多癌症之中，高達接近70%的胰臟癌病人會出現cancer cachexia，總體重的損失在六個月內可高達25%。418Please respect copyright.ＰＥＮＡＮＡgUbHqNR21J
相反，患上前列腺癌的病人僅只有約10%的人出現cancer cachexia。418Please respect copyright.ＰＥＮＡＮＡO1rpZx0q7K
418Please respect copyright.ＰＥＮＡＮＡ0UIZ0UnwYQ
418Please respect copyright.ＰＥＮＡＮＡOFAGJ9dGeZ
(圖2)病人出現cancer cachexia的話(以體重損失超過10%為指標)，其生存的機率亦會因而顯著下降。418Please respect copyright.ＰＥＮＡＮＡwTIkWSGKMB
418Please respect copyright.ＰＥＮＡＮＡxmRVAPR4NA
418Please respect copyright.ＰＥＮＡＮＡtsosoFyxWl
正因如此，若能了解其cancer cachexia機制並加以針對的話，將會是抵抗癌症的其中一道手法。418Please respect copyright.ＰＥＮＡＮＡIREH1kRsM5
418Please respect copyright.ＰＥＮＡＮＡoLUY85hOyq
418Please respect copyright.ＰＥＮＡＮＡSG3cqWRiUv
(圖3)癌細胞所導致的體重流失，主要是由肌肉喪失所致。418Please respect copyright.ＰＥＮＡＮＡSpL3H3VS9M
而當我們的肌肉受到傷害或撕裂的時候，裡頭的幹細胞以及圖中所指的細胞將會出手幫忙製造肌肉，填補其損失。418Please respect copyright.ＰＥＮＡＮＡCokPOCjF6z
418Please respect copyright.ＰＥＮＡＮＡtcSibZFSNy
418Please respect copyright.ＰＥＮＡＮＡYsaUVodblY
418Please respect copyright.ＰＥＮＡＮＡkkkO8KqTzm
癌細胞的厲害之處就是能夠釋出物質經由血管到達肌肉，誘導肌肉出現受傷情況之餘，並同時阻止肌肉幹細胞進行重生，因而導致肌肉流失情況發生。418Please respect copyright.ＰＥＮＡＮＡLyIu3SUMla
418Please respect copyright.ＰＥＮＡＮＡtlca6CaStm
癌細胞之所以這樣做，其中的一道推論是希望透過破壞肌肉而使血液間的氨基酸(蛋白質)含量增加，然後借助肝臟把這些氨基酸轉變成糖份，再由血液循環系統輸送給自身所用。418Please respect copyright.ＰＥＮＡＮＡR8T6xvDRVR
418Please respect copyright.ＰＥＮＡＮＡELOB1WPQw7
因著胰臟癌病人出現cancer cachexia的機率較高，有不少科學家均就此利用老鼠胰臟癌模型來研究cancer cachexia的機制。418Please respect copyright.ＰＥＮＡＮＡdq4zlmrrmQ
418Please respect copyright.ＰＥＮＡＮＡfXYHwj8rBQ
至今已至少找出得到，癌細胞所釋出的物質會導致肌肉幹細胞一種名為Pax7的蛋白質含量不斷上升，並因而導致肌肉幹細胞沒法子進行重組肌肉舉動。418Please respect copyright.ＰＥＮＡＮＡFEBcy71Gi6
418Please respect copyright.ＰＥＮＡＮＡM8zoFA5Xbj
418Please respect copyright.ＰＥＮＡＮＡbOsYaLCQ6M
418Please respect copyright.ＰＥＮＡＮＡDQomAEsdJd
418Please respect copyright.ＰＥＮＡＮＡNktjYAQ4pP
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。418Please respect copyright.ＰＥＮＡＮＡgd9V0h36uE
418Please respect copyright.ＰＥＮＡＮＡK5JBhItjDQ
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc418Please respect copyright.ＰＥＮＡＮＡOL55QsWpxk
418Please respect copyright.ＰＥＮＡＮＡzmrRioevSQ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。418Please respect copyright.ＰＥＮＡＮＡzPEfJCcAdP
418Please respect copyright.ＰＥＮＡＮＡZ8wxA42E8S
Link:418Please respect copyright.ＰＥＮＡＮＡSiNCzNA0bh
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio418Please respect copyright.ＰＥＮＡＮＡYpNOJzDrVn
418Please respect copyright.ＰＥＮＡＮＡdW1EMb0MPs
418Please respect copyright.ＰＥＮＡＮＡjHj0LkBTDX
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。418Please respect copyright.ＰＥＮＡＮＡVgcBulOnwT
418Please respect copyright.ＰＥＮＡＮＡ1SF08xllAR
Ref1:https://www.nature.com/articles/nrdp2017105418Please respect copyright.ＰＥＮＡＮＡbWQD25fBmU

ns18.189.143.114da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章