此為上集的補充篇:三十秒科學–癌症所導致的體重流失681Please respect copyright.ＰＥＮＡＮＡfcQL6E74Jt
https://lih.kg/2397914681Please respect copyright.ＰＥＮＡＮＡtY5PskR5VJ
681Please respect copyright.ＰＥＮＡＮＡwOCHlPwvqI
癌症惡病質(cancer cachexia)泛指因癌症而導致的體重流失，大部份情況下主要是由喪失肌肉所致，並沒法依靠進食來填補其喪失。681Please respect copyright.ＰＥＮＡＮＡ9Y0WPVlUrE
681Please respect copyright.ＰＥＮＡＮＡxAZRNtOoKQ
681Please respect copyright.ＰＥＮＡＮＡHoj7hemFcc
在眾多癌症之中，高達接近70%的胰臟癌病人會出現cancer cachexia，總體重的損失在六個月內可高達25%。681Please respect copyright.ＰＥＮＡＮＡFOqiQwUFpq
相反，患上前列腺癌的病人僅只有約10%的人出現cancer cachexia。681Please respect copyright.ＰＥＮＡＮＡGJnmyITQuj
681Please respect copyright.ＰＥＮＡＮＡ01LgQO8BxJ
681Please respect copyright.ＰＥＮＡＮＡz6nx7wpatd
(圖2)病人出現cancer cachexia的話(以體重損失超過10%為指標)，其生存的機率亦會因而顯著下降。681Please respect copyright.ＰＥＮＡＮＡTCToFroBn2
681Please respect copyright.ＰＥＮＡＮＡDtkP5ikLdQ
681Please respect copyright.ＰＥＮＡＮＡnB6U5stAO3
正因如此，若能了解其cancer cachexia機制並加以針對的話，將會是抵抗癌症的其中一道手法。681Please respect copyright.ＰＥＮＡＮＡz8oaHjDmee
681Please respect copyright.ＰＥＮＡＮＡ8fFGGiIKLB
681Please respect copyright.ＰＥＮＡＮＡQfrYFhZAqi
(圖3)癌細胞所導致的體重流失，主要是由肌肉喪失所致。681Please respect copyright.ＰＥＮＡＮＡ9F0CCdj0G2
而當我們的肌肉受到傷害或撕裂的時候，裡頭的幹細胞以及圖中所指的細胞將會出手幫忙製造肌肉，填補其損失。681Please respect copyright.ＰＥＮＡＮＡIky968pRHs
681Please respect copyright.ＰＥＮＡＮＡtne4NYnaNt
681Please respect copyright.ＰＥＮＡＮＡNrgiA5hQOy
681Please respect copyright.ＰＥＮＡＮＡs3NS0WBmYt
癌細胞的厲害之處就是能夠釋出物質經由血管到達肌肉，誘導肌肉出現受傷情況之餘，並同時阻止肌肉幹細胞進行重生，因而導致肌肉流失情況發生。681Please respect copyright.ＰＥＮＡＮＡYnjCVtiyWk
681Please respect copyright.ＰＥＮＡＮＡjNLePo4zSD
癌細胞之所以這樣做，其中的一道推論是希望透過破壞肌肉而使血液間的氨基酸(蛋白質)含量增加，然後借助肝臟把這些氨基酸轉變成糖份，再由血液循環系統輸送給自身所用。681Please respect copyright.ＰＥＮＡＮＡnCa2huwM7u
681Please respect copyright.ＰＥＮＡＮＡNYYeokupbt
因著胰臟癌病人出現cancer cachexia的機率較高，有不少科學家均就此利用老鼠胰臟癌模型來研究cancer cachexia的機制。681Please respect copyright.ＰＥＮＡＮＡVSbBJlh087
681Please respect copyright.ＰＥＮＡＮＡrj4u232nu1
至今已至少找出得到，癌細胞所釋出的物質會導致肌肉幹細胞一種名為Pax7的蛋白質含量不斷上升，並因而導致肌肉幹細胞沒法子進行重組肌肉舉動。681Please respect copyright.ＰＥＮＡＮＡmBCHmTzhQk
681Please respect copyright.ＰＥＮＡＮＡ8jDHavgiTP
681Please respect copyright.ＰＥＮＡＮＡxc6mKvEP6p
681Please respect copyright.ＰＥＮＡＮＡOQLgxixFFR
681Please respect copyright.ＰＥＮＡＮＡsgULlo3EMQ
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。681Please respect copyright.ＰＥＮＡＮＡuGO3qN1IKs
681Please respect copyright.ＰＥＮＡＮＡU3fU2JJkYa
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc681Please respect copyright.ＰＥＮＡＮＡbKJcqUkEZN
681Please respect copyright.ＰＥＮＡＮＡGcjejj8MoW
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。681Please respect copyright.ＰＥＮＡＮＡJw5FdwqNPJ
681Please respect copyright.ＰＥＮＡＮＡeqtdltCO7a
Link:681Please respect copyright.ＰＥＮＡＮＡKClSqVbdDn
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio681Please respect copyright.ＰＥＮＡＮＡa2K3SJSDD4
681Please respect copyright.ＰＥＮＡＮＡn5s2OpSSiB
681Please respect copyright.ＰＥＮＡＮＡnj7pNgLh0l
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。681Please respect copyright.ＰＥＮＡＮＡCRW82gDFJ3
681Please respect copyright.ＰＥＮＡＮＡ0D3WeCcnU4
Ref1:https://www.nature.com/articles/nrdp2017105681Please respect copyright.ＰＥＮＡＮＡHraqKnKp9b
1234 copyright protection677ＰＥＮＡＮＡFeHn2fppdX 尼

216.73.216.217