科普專欄–薯不揀單 - 三十秒科學–心臟肥大

當血壓長期處於過高狀態的時候，便有機會出現心臟肥大(Cardiac hypertrophy)的情況。425Please respect copyright.ＰＥＮＡＮＡI2JjRMQDEY
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(圖2)心臟的肌肉會利用收縮及膨脹的舉動把血液送到全身，如果血壓高企的話，心臟肌肉細胞便會自行膨脹增大，好使心臟有更強力量抵禦血液帶來的壓力，且能繼續維持正常功能把血液送往全身。425Please respect copyright.ＰＥＮＡＮＡbg98oGL8ZS
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這現象稱之為心臟肥大(Cardiac hypertrophy)。425Please respect copyright.ＰＥＮＡＮＡ7YiN7IWmCB
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(圖3)當血壓持續高企及攀升到某一個位，心臟的肌肉再也沒法透過膨脹增大來維持運作，這時候心臟便會進入「放棄人生」的狀態，再也不會激烈地膨脹收縮，形成心臟衰竭(Heart failure)局面，血液因而再也沒能輸送到身體各部位。425Please respect copyright.ＰＥＮＡＮＡB2i6W4TRq4
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換句話說，長期因高血壓所造成的心臟肥大(Cardiac hypertrophy)，會是形成心臟衰竭(Heart failure)的其中一道誘因。425Please respect copyright.ＰＥＮＡＮＡdr9TmQAj0k
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(圖4)有見及此，有不少科學家會以人工方式在動物模型上製造心臟肥大(Cardiac hypertrophy)的局面，藉此了解箇中對細胞所做成的影響，從而找出防止下一步心臟衰竭(Heart failure)的潛在發生。425Please respect copyright.ＰＥＮＡＮＡj1hfxSyKzC
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其中的一種手段，就是利用縫線的手法局部減低心臟血管血液流動的動向。425Please respect copyright.ＰＥＮＡＮＡvpmLe8fDMF
從圖中可見，縫線後左心房所承受的血壓將會大幅度增強。425Please respect copyright.ＰＥＮＡＮＡeAsVbXe89B
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(圖5)圖中可以清晰見得到，縫線後左心房的確出現肥大的狀況。425Please respect copyright.ＰＥＮＡＮＡoYPYjJpfSU
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而這些動物的付出，確實是為人類的健康作出了非常大的貢獻，下集將會再作進一步的講解。425Please respect copyright.ＰＥＮＡＮＡormmewDeQ8
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Ref1:https://pubmed.ncbi.nlm.nih.gov/12738623/

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