科普專欄–薯不揀單 - 三十秒科學–心臟肥大(2)

上集略述了心臟肥大與心臟衰竭的關連，今集將會講述一道暫緩心臟由肥大演變成衰竭的研究。580Please respect copyright.ＰＥＮＡＮＡotV1BNaLRX
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上集:https://lih.kg/gOrCdS580Please respect copyright.ＰＥＮＡＮＡ4NmIPgfQ51
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(圖2)研究發現，當利用縫線手法引致心臟處於肥大狀態的時候，一隻名為GRK5的蛋白質會從心肌細胞的內部轉移到細胞核裡頭。580Please respect copyright.ＰＥＮＡＮＡC6juIBRYyi
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(圖3)當GRK5進入細胞核後，它便會依靠圖中其紅色的部份與其他蛋白質(橙色)互動，因而改變其自身的形狀，發揮一系列的功效引致心臟肥大。580Please respect copyright.ＰＥＮＡＮＡuTSiNyvoZ8
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見狀，科學家便特意單獨注入其紅色部份到細胞核，目的就是想透過紅色部份的霸佔，阻截完整的GRK5蛋白質與其他蛋白質(橙色)互動，使其功效喪失。580Please respect copyright.ＰＥＮＡＮＡ69uaz4FZXr
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形象化來說，就是某勢力派人霸佔旁聽座位，讓其他人士無法入座。580Please respect copyright.ＰＥＮＡＮＡqYzEKl73M6
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(圖4)縫線後所引起的心臟肥大，並沒有出現在注入紅色部份蛋白質的老鼠心臟裡頭。580Please respect copyright.ＰＥＮＡＮＡ2MQCMFRIzk
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最為重要的是，心臟肥大所引起的心肌纖維化(藍色箭嘴)，並沒有能夠在注入紅色部份蛋白質的老鼠心臟裡頭找得到。580Please respect copyright.ＰＥＮＡＮＡCcawfaDLYQ
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換句話說，這GRK5的紅色部份，非常之有潛質可以發展成為抵抗血壓過高引致的心臟肥大藥物。580Please respect copyright.ＰＥＮＡＮＡ5viQb1NbCG
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Ref1:https://stke.sciencemag.org/content/14/676/eabb5968580Please respect copyright.ＰＥＮＡＮＡJGvrDiajn3

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