上集略述了心臟肥大與心臟衰竭的關連，今集將會講述一道暫緩心臟由肥大演變成衰竭的研究。752Please respect copyright.ＰＥＮＡＮＡvBVd3HFTS3
752Please respect copyright.ＰＥＮＡＮＡci0GMyGaqK
752Please respect copyright.ＰＥＮＡＮＡ9wsZooBJ6N
上集:https://lih.kg/gOrCdS752Please respect copyright.ＰＥＮＡＮＡpod3Lno9LD
752Please respect copyright.ＰＥＮＡＮＡnT8g4ioYk6
(圖2)研究發現，當利用縫線手法引致心臟處於肥大狀態的時候，一隻名為GRK5的蛋白質會從心肌細胞的內部轉移到細胞核裡頭。752Please respect copyright.ＰＥＮＡＮＡrSjQPV5lSX
752Please respect copyright.ＰＥＮＡＮＡXGT1nu7bLg
752Please respect copyright.ＰＥＮＡＮＡRJuRqQJMs3
752Please respect copyright.ＰＥＮＡＮＡBZyoJbg1iR
(圖3)當GRK5進入細胞核後，它便會依靠圖中其紅色的部份與其他蛋白質(橙色)互動，因而改變其自身的形狀，發揮一系列的功效引致心臟肥大。752Please respect copyright.ＰＥＮＡＮＡ5UozITc6hv
752Please respect copyright.ＰＥＮＡＮＡds2Rx0PcVO
752Please respect copyright.ＰＥＮＡＮＡOSh7UvqruF
見狀，科學家便特意單獨注入其紅色部份到細胞核，目的就是想透過紅色部份的霸佔，阻截完整的GRK5蛋白質與其他蛋白質(橙色)互動，使其功效喪失。752Please respect copyright.ＰＥＮＡＮＡkvZ1qNR8dr
752Please respect copyright.ＰＥＮＡＮＡnSbFUWpAv6
形象化來說，就是某勢力派人霸佔旁聽座位，讓其他人士無法入座。752Please respect copyright.ＰＥＮＡＮＡdiKximcyB8
752Please respect copyright.ＰＥＮＡＮＡy95k1FS7eR
752Please respect copyright.ＰＥＮＡＮＡnQrOYgjKAb
(圖4)縫線後所引起的心臟肥大，並沒有出現在注入紅色部份蛋白質的老鼠心臟裡頭。752Please respect copyright.ＰＥＮＡＮＡwecifY6HUi
752Please respect copyright.ＰＥＮＡＮＡRqc9sjDVPL
752Please respect copyright.ＰＥＮＡＮＡ8Bk0jLjXDt
最為重要的是，心臟肥大所引起的心肌纖維化(藍色箭嘴)，並沒有能夠在注入紅色部份蛋白質的老鼠心臟裡頭找得到。752Please respect copyright.ＰＥＮＡＮＡu6973wRBlD
752Please respect copyright.ＰＥＮＡＮＡstqsm2NdWQ
752Please respect copyright.ＰＥＮＡＮＡC87SFLeNQI
換句話說，這GRK5的紅色部份，非常之有潛質可以發展成為抵抗血壓過高引致的心臟肥大藥物。752Please respect copyright.ＰＥＮＡＮＡJmMpazx6CQ
752Please respect copyright.ＰＥＮＡＮＡCV0WXp4W3U
752Please respect copyright.ＰＥＮＡＮＡtz7kLkDaH1
752Please respect copyright.ＰＥＮＡＮＡHbgE02wRxS
752Please respect copyright.ＰＥＮＡＮＡSFUVXUPITV
752Please respect copyright.ＰＥＮＡＮＡIuy19M6HjV
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。752Please respect copyright.ＰＥＮＡＮＡe3J9buxSOm
752Please respect copyright.ＰＥＮＡＮＡQceAZqAkc3
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc752Please respect copyright.ＰＥＮＡＮＡMvML3nC90g
752Please respect copyright.ＰＥＮＡＮＡl7RzmXLzys
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。752Please respect copyright.ＰＥＮＡＮＡIZsJilvQqd
752Please respect copyright.ＰＥＮＡＮＡJZ33S99EhC
Link:752Please respect copyright.ＰＥＮＡＮＡV3HO204sMt
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio752Please respect copyright.ＰＥＮＡＮＡI6SM7Y7bED
752Please respect copyright.ＰＥＮＡＮＡSLXsDZzrlM
752Please respect copyright.ＰＥＮＡＮＡbLRBA7MGfR
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。752Please respect copyright.ＰＥＮＡＮＡY2mbeYVkug
752Please respect copyright.ＰＥＮＡＮＡfC1PvPLVvx
Ref1:https://stke.sciencemag.org/content/14/676/eabb5968752Please respect copyright.ＰＥＮＡＮＡn0C4TVNbW6
1234 copyright protection748ＰＥＮＡＮＡXFV4RplCLe 尼

216.73.216.208