上集略述了心臟肥大與心臟衰竭的關連,今集將會講述一道暫緩心臟由肥大演變成衰竭的研究。488Please respect copyright.PENANAGi7DKoXn1v488Please respect copyright.PENANAGaf2rm2shH
488Please respect copyright.PENANAKtwH6JnP4b
上集:https://lih.kg/gOrCdS488Please respect copyright.PENANAVBTaXRQKTH
488Please respect copyright.PENANAJTK2TKuDLU
(圖2)研究發現,當利用縫線手法引致心臟處於肥大狀態的時候,一隻名為GRK5的蛋白質會從心肌細胞的內部轉移到細胞核裡頭。488Please respect copyright.PENANAwdv22Hk26y488Please respect copyright.PENANAClE8UHU608
488Please respect copyright.PENANA965uCyI92b
488Please respect copyright.PENANAA6G1ljNMYX
(圖3)當GRK5進入細胞核後,它便會依靠圖中其紅色的部份與其他蛋白質(橙色)互動,因而改變其自身的形狀,發揮一系列的功效引致心臟肥大。488Please respect copyright.PENANAgwyPmg4VOY488Please respect copyright.PENANAP8cZTMzvK0
488Please respect copyright.PENANAN6UxkUo5W0
見狀,科學家便特意單獨注入其紅色部份到細胞核,目的就是想透過紅色部份的霸佔,阻截完整的GRK5蛋白質與其他蛋白質(橙色)互動,使其功效喪失。488Please respect copyright.PENANAjZ583SaQ8n
488Please respect copyright.PENANApY6Z8OHhRO
形象化來說,就是某勢力派人霸佔旁聽座位,讓其他人士無法入座。488Please respect copyright.PENANAnInRuuB0oe
488Please respect copyright.PENANAYlFcOrgtlc
488Please respect copyright.PENANAcbcZGEmSm3
(圖4)縫線後所引起的心臟肥大,並沒有出現在注入紅色部份蛋白質的老鼠心臟裡頭。488Please respect copyright.PENANANTbMe7dJlo488Please respect copyright.PENANAHCdPPzBmgk
488Please respect copyright.PENANAuwtYcI8fXB
最為重要的是,心臟肥大所引起的心肌纖維化(藍色箭嘴),並沒有能夠在注入紅色部份蛋白質的老鼠心臟裡頭找得到。488Please respect copyright.PENANADts1jPK4bp
488Please respect copyright.PENANAHyQoHC4Sqg
488Please respect copyright.PENANAOBpOVphUJO
換句話說,這GRK5的紅色部份,非常之有潛質可以發展成為抵抗血壓過高引致的心臟肥大藥物。488Please respect copyright.PENANAjobS5dNZHZ
488Please respect copyright.PENANAMEhtiLrPuz
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488Please respect copyright.PENANAdjemcicXtb
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488Please respect copyright.PENANASEOB25PSKk
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。488Please respect copyright.PENANAfDXwVujjDn
488Please respect copyright.PENANAa0OtSV7RYa
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc488Please respect copyright.PENANAPD1asgLvxh
488Please respect copyright.PENANAG82ov3uyCn
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。488Please respect copyright.PENANABzI5pGSFAu
488Please respect copyright.PENANAiV9sPvLbBI
Link:488Please respect copyright.PENANA5EWyXu6rss
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio488Please respect copyright.PENANA3rV42xpLT1
488Please respect copyright.PENANAdNhHE6IW9U
488Please respect copyright.PENANAlQTPugBDJ0
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。488Please respect copyright.PENANAfyrUfe8mso
488Please respect copyright.PENANA27XZKdkdGB
Ref1:https://stke.sciencemag.org/content/14/676/eabb5968488Please respect copyright.PENANAVot1WqoPmW
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作者:
薯仔聞茱莉

篇 #194
三十秒科學–心臟肥大(2)
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