科普專欄–薯不揀單 - 三十秒科學–降膽固醇藥

油並無法容易溶於水裡，因此當脂肪從我們身體的血液循環系統時，便需要依靠蛋白質的輔助，合體成為脂蛋白(Lipoprotein)，才能方便於血液中流動行走。921Please respect copyright.ＰＥＮＡＮＡp7DUuoWOc9
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（圖2）根據密度及體積，脂蛋白可分成為不同種類。921Please respect copyright.ＰＥＮＡＮＡPFnQxuq170
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Low Density Lipoprotein(LDL)主要負責從肝臟把油脂傳送到各器官，而血液LDL含量長期高企的話，患上心臟病或中風的機會亦會高企，因此經常被冠稱為壞膽固醇。921Please respect copyright.ＰＥＮＡＮＡ7ngR8VFySP
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而當細胞尤其是肝臟細胞內的膽固醇過多的話，便會以High Density Lipoprotein(HDL)的形式排出細胞外。921Please respect copyright.ＰＥＮＡＮＡovp945ulaf
細胞內含有過多膽固醇的話便會觸發細胞進行死亡的機制，基於HDL能把它們帶出細胞外，避免壞事發生，因此亦被稱之為好膽固醇。921Please respect copyright.ＰＥＮＡＮＡ0SG98fQN6D
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（圖3）細胞可從外間直接攝取膽固醇，又或者是從其他原料自行製作膽固醇。921Please respect copyright.ＰＥＮＡＮＡvZj0wYpMkr
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降膽固醇藥Statin能夠抑制其中一隻參與製作膽固醇過程的酶素，導致膽固醇的製作無法順利完成。921Please respect copyright.ＰＥＮＡＮＡVXuVpIisGT
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而細胞在藥物的誤導下，以為是自己因為吸收不足夠的LDL，所以無法製作膽固醇，因此便會增大吸收外間LDL的能力，得出的結果就是把血液裡的壞膽固醇含量大幅度下降。921Please respect copyright.ＰＥＮＡＮＡmg8A3F8VUH
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能降低血液LDL含量固然是一件好事，畢竟血液LDL含量與心臟病中風等疾病有著密切的關聯。921Please respect copyright.ＰＥＮＡＮＡGHNVmV2Clw
但亦有一些統計數據指出服用Statin會增加患癌風險，其機制現時尚未能搞得清楚。921Please respect copyright.ＰＥＮＡＮＡlh06cB69Tb
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Statin藥物所抑制的製作膽固醇的機制，箇中亦包含其他有用的有機物及代謝物製作。921Please respect copyright.ＰＥＮＡＮＡLsTt9fhbrp
干涉到那些有機物的製作會否促成癌症生長，還需要大量的研究作出探討。921Please respect copyright.ＰＥＮＡＮＡmz2fFKfHoJ
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。921Please respect copyright.ＰＥＮＡＮＡsHSMF9uA4S
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc921Please respect copyright.ＰＥＮＡＮＡn3RqXRdgdy
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。921Please respect copyright.ＰＥＮＡＮＡONAdqIe2YA
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Link:921Please respect copyright.ＰＥＮＡＮＡpFNSt4MCwj
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio921Please respect copyright.ＰＥＮＡＮＡSFOo8kO93h
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。921Please respect copyright.ＰＥＮＡＮＡzx2JBcJNbW
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Ref1:https://pubmed.ncbi.nlm.nih.gov/8561503/921Please respect copyright.ＰＥＮＡＮＡtVFbBoSOaR
Ref2:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225778/921Please respect copyright.ＰＥＮＡＮＡ2cZdNyEdbY

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