科普專欄–薯不揀單 - 三十秒科學–中國武肺(Cansino)疫苗與牛津疫苗的方別

國藥及科興是中國兩款滅活病毒疫苗。而科興數據其可信性之高，就連公開聲稱戴口罩便沒法說話的梁卓偉院長也怕怕唔敢打。515Please respect copyright.ＰＥＮＡＮＡ6Tn1iunBYA
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大概是因為中國頭兩款疫苗過於「聲名大噪」，其第三款疫苗康希諾疫苗的關注度則相對較為低。而事實上，康希諾(Cansino)的疫苗設計其實是跟牛津疫苗非常相似。515Please respect copyright.ＰＥＮＡＮＡYiwGFBxxGM
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(圖2)圖中為康希諾及牛津疫苗兩款疫苗的扼要原理。515Please respect copyright.ＰＥＮＡＮＡgHOJ9nnZEt
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1.疫苗的主要成份為已被削弱複製能力且無害的病毒，內含武肺S蛋白的DNA資訊。515Please respect copyright.ＰＥＮＡＮＡLlHF9uSBLU
2. 病毒進入人體細胞。515Please respect copyright.ＰＥＮＡＮＡKKPUkqzg69
3. 人體細胞利用病毒內含的武肺S蛋白DNA資訊，製作武肺S蛋白。515Please respect copyright.ＰＥＮＡＮＡYXPQtRASwy
4.免疫系統的相關細胞辨認武肺S蛋白是為外來之物，因而製作相應的抗體。515Please respect copyright.ＰＥＮＡＮＡhlPhxB7qgx
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（圖3）因為康希諾疫苗所用的是人類常見的感冒病毒，約4-6成的人早已擁有對抗這感冒病毒的抗體，因此病毒還沒能進入細胞之前（圖2的步驟2），便早已被自身的抗體攔截。515Please respect copyright.ＰＥＮＡＮＡw7QMaiEzEh
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而牛津所用的是黑猩猩所搵到的感冒病毒，原理上人體並沒有對應的抗體，因此亦相對上更易進入細胞。515Please respect copyright.ＰＥＮＡＮＡa29NtnBvCi
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以這方面來看，牛津疫苗的設計比康希諾技勝一籌。515Please respect copyright.ＰＥＮＡＮＡ6GDT4Gghep
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最近Bloomberg (Ref3)表示Cansino疫苗的保護效率達65.7%，而它跟Johnson&Johnson的疫苗一樣，均是一次性的方式注射。515Please respect copyright.ＰＥＮＡＮＡiEUgc1rw1t
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延伸閱讀:515Please respect copyright.ＰＥＮＡＮＡlZl1Ii4dPw
深入淺出–林鄭注射輝瑞/科興疫苗的最壞後果515Please respect copyright.ＰＥＮＡＮＡvlkaM6Q4oX
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。515Please respect copyright.ＰＥＮＡＮＡGD6N3iOV4N
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc515Please respect copyright.ＰＥＮＡＮＡ9IWlNo36TG
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。515Please respect copyright.ＰＥＮＡＮＡywPXET8BEj
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Ref1:https://science.sciencemag.org/content/370/6522/1263515Please respect copyright.ＰＥＮＡＮＡlBlYkUoF59
Ref2:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067905/515Please respect copyright.ＰＥＮＡＮＡRtFaP0PfdZ
Ref3:https://www.bloomberg.com/news/articles/2021-02-08/pakistan-says-cansino-s-covid-vaccine-shows-65-7-efficacy515Please respect copyright.ＰＥＮＡＮＡJWAwfcG5ZC

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