科普專欄–薯不揀單 - 三十秒科學–癌細胞嗜糖的原因

癌細胞經常被描繪為極度嗜糖。的而且確，大部份的癌細胞對比同等類型的正常細胞均會攝取更多的糖份。528Please respect copyright.ＰＥＮＡＮＡGdHpHrePp9
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箇中的原因至少有三:528Please respect copyright.ＰＥＮＡＮＡyw6chce2gh
1.致癌基因的表達率增加528Please respect copyright.ＰＥＮＡＮＡD55Ez9yNF4
2.新陳代謝酶素變異528Please respect copyright.ＰＥＮＡＮＡACFwDhFVHd
3.周遭環境缺乏氧氣528Please respect copyright.ＰＥＮＡＮＡkOsm1t4IXR
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（圖2）沒有氧氣的話，脂肪及氨基酸並不能轉化成為可供細胞所用的能源。528Please respect copyright.ＰＥＮＡＮＡF1vJKkJSn7
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然而，糖份在擁有氧氣或缺乏氧氣的情況下，均可轉化成為能源。528Please respect copyright.ＰＥＮＡＮＡPhVmq24qAQ
因此，當癌細胞處於缺氧狀態的時候，便會增加對糖份的依賴。528Please respect copyright.ＰＥＮＡＮＡRAHu2YwVsY
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（圖3）正常的細胞有著一套完善的機制控制著其生長速度，而這些機制大多數時候均會在癌細胞發發生的基因變異影響下作廢，促使癌細胞能夠無止境地生長及繁殖。528Please respect copyright.ＰＥＮＡＮＡUwM5zDPFYn
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當一個細胞需要繁殖的時候，細胞膜以及DNA是不可或缺的元件。528Please respect copyright.ＰＥＮＡＮＡCZN4zJsAu5
而在糖份分解的過程中，所涉及的代謝物均能參與細胞膜和DNA的製作。528Please respect copyright.ＰＥＮＡＮＡFJvAE25Q7d
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亦即是說，癌細胞不斷無止境地生長，導致內部位置沒有足夠氧氣，正好更能觸發更多糖份的攝取，繼續製作繁殖所需的細胞組件。528Please respect copyright.ＰＥＮＡＮＡetVbU4TJ5U
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但是，若氧氣沒能抵達癌細胞的話，那又如何能夠獲取營養呢？528Please respect copyright.ＰＥＮＡＮＡPH0W9AEb1u
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其中的一種渠道，就是從鄰近死去的細胞獲取。528Please respect copyright.ＰＥＮＡＮＡvSoIP7p9HJ
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詳見可閱：528Please respect copyright.ＰＥＮＡＮＡvij50PTJ4Q
三十秒科學–化療效果參差的其中一道原因528Please respect copyright.ＰＥＮＡＮＡlZMh6Mm8Rc
- 分享自 LIHKG 討論區528Please respect copyright.ＰＥＮＡＮＡs0HUlOQ8SP
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正因如此，腫瘤的核心大多是已死去的細胞，而其外部則是不斷繁殖的細胞。528Please respect copyright.ＰＥＮＡＮＡrhvsEuBkUA
而經過一段時間的繁殖後，早前的「外部」細胞便成為「核心」，成為鄰近細胞的糧食。528Please respect copyright.ＰＥＮＡＮＡUlgGN9a9jY
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日復如此，腫瘤亦得以無止境助大。528Please respect copyright.ＰＥＮＡＮＡCg1loqz4OL
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