化療殺滅癌細胞的效率非常參差,有些情況更反而會導致癌細胞加速生長,究竟為何會這樣?347Please respect copyright.PENANAaXsTdnbso2347Please respect copyright.PENANAlUy79o5M7h
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(圖2)使用化療藥物過後,某些癌細胞的確是會歸西死亡。347Please respect copyright.PENANAewdBCK3nuS
而細胞死亡的方式有好幾種,其中兩種為Apoptosis及Necrosis。347Please respect copyright.PENANAGLapCmvoP8347Please respect copyright.PENANAB0m3CiaVUK
347Please respect copyright.PENANARstFNAZXsV
如圖中所見,進行Apoptosis的細胞會呈完整球狀,屍體相對的體積較大。347Please respect copyright.PENANAi1wnposI3r
而進行Necrosis的細胞則會分成為不規則的碎塊,體積亦較細。347Please respect copyright.PENANA7i38dexzfj
347Please respect copyright.PENANAg03kuWClYG
(圖3)形象化來說,Apoptosis就是曲奇餅,而Necrosis就是曲奇餅碎。347Please respect copyright.PENANAiJi3zS9ZnE347Please respect copyright.PENANAG9Q0azIb6w
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(圖4)癌細胞被化療藥物殺死後,若進行Necrosis,鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制,將死亡的細胞吞噬,作營養供用使自己繼續成長,抵禦化療藥物所帶來的困境。347Please respect copyright.PENANAZU4OYNAloB347Please respect copyright.PENANAf060ARKzI8
347Please respect copyright.PENANAQY2AZm1Fol
但細胞進行Apoptosis的話,因屍體體積過大,鄰近的細胞便不能把其吞噬。347Please respect copyright.PENANAV8wQ891KKV
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並不是所有癌細胞亦能懂得施展Macropinocytosis,而整個機制學界亦在模索之中,只知道某些基因如PI3K或Ras進行突變的話,Macropinocytosis發生的機率亦會較大。347Please respect copyright.PENANAeaXxrretxx
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若能掌握整套機制及研發藥物制止Macropinocytosis的發生,並在化療藥物其間同時使用,便能壓抑癌細胞吞噬死亡細胞的機制,大大增加化療的效果。347Please respect copyright.PENANAekERNXArRX
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347Please respect copyright.PENANAgrF8hiSi4k
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。347Please respect copyright.PENANAQTg06aeDo0
347Please respect copyright.PENANAfof8uJeIyp
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc347Please respect copyright.PENANAiGAL16LH1y
347Please respect copyright.PENANAgDGXh7qNcB
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。347Please respect copyright.PENANAnrSD5oIyeL
347Please respect copyright.PENANAa0Z6kjsVpd
Link:347Please respect copyright.PENANAZTRMzGgcoa
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio347Please respect copyright.PENANA1sdjeceSpD
347Please respect copyright.PENANAjAbOH4KNF9
347Please respect copyright.PENANAWRXnPINCiR
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。347Please respect copyright.PENANAB0nrVnBVwf
347Please respect copyright.PENANALOGvanDer9
Ref1:https://www.nature.com/articles/s41467-020-14928-3347Please respect copyright.PENANAzPuNjxqCV1
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科普專欄–薯不揀單
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薯仔聞茱莉
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ISSUE #143
三十秒科學–化療效果參差的其中一道原因
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