科普專欄–薯不揀單 - 三十秒科學–化療效果參差的其中一道原因

化療殺滅癌細胞的效率非常參差，有些情況更反而會導致癌細胞加速生長，究竟為何會這樣?578Please respect copyright.ＰＥＮＡＮＡ1F3NsVuwXH
578Please respect copyright.ＰＥＮＡＮＡIWgq2fEy5f
578Please respect copyright.ＰＥＮＡＮＡYGyR0Z5Gh0
（圖2）使用化療藥物過後，某些癌細胞的確是會歸西死亡。578Please respect copyright.ＰＥＮＡＮＡqysQRfJJ8Q
而細胞死亡的方式有好幾種，其中兩種為Apoptosis及Necrosis。578Please respect copyright.ＰＥＮＡＮＡuXguEzE1MX
578Please respect copyright.ＰＥＮＡＮＡxlYYocpDDy
578Please respect copyright.ＰＥＮＡＮＡj7EtfIxCyd
如圖中所見，進行Apoptosis的細胞會呈完整球狀，屍體相對的體積較大。578Please respect copyright.ＰＥＮＡＮＡKRATgn9c0Q
而進行Necrosis的細胞則會分成為不規則的碎塊，體積亦較細。578Please respect copyright.ＰＥＮＡＮＡzflxwJDsL4
578Please respect copyright.ＰＥＮＡＮＡZOgY11na1M
（圖3）形象化來說，Apoptosis就是曲奇餅，而Necrosis就是曲奇餅碎。578Please respect copyright.ＰＥＮＡＮＡEKfLtvVl5H
578Please respect copyright.ＰＥＮＡＮＡGVixvXx6BD
578Please respect copyright.ＰＥＮＡＮＡjWpG3YTRfw
578Please respect copyright.ＰＥＮＡＮＡdffZ1TWKPy
（圖4）癌細胞被化療藥物殺死後，若進行Necrosis，鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制，將死亡的細胞吞噬，作營養供用使自己繼續成長，抵禦化療藥物所帶來的困境。578Please respect copyright.ＰＥＮＡＮＡmXchuNadii
578Please respect copyright.ＰＥＮＡＮＡTZ8JRs2v2i
578Please respect copyright.ＰＥＮＡＮＡSC5sWiamRa
但細胞進行Apoptosis的話，因屍體體積過大，鄰近的細胞便不能把其吞噬。578Please respect copyright.ＰＥＮＡＮＡ3Im0IL9abn
578Please respect copyright.ＰＥＮＡＮＡ3zcJLGUlJD
並不是所有癌細胞亦能懂得施展Macropinocytosis，而整個機制學界亦在模索之中，只知道某些基因如PI3K或Ras進行突變的話，Macropinocytosis發生的機率亦會較大。578Please respect copyright.ＰＥＮＡＮＡjO4OIlg5yx
578Please respect copyright.ＰＥＮＡＮＡEizOxB5Zv9
若能掌握整套機制及研發藥物制止Macropinocytosis的發生，並在化療藥物其間同時使用，便能壓抑癌細胞吞噬死亡細胞的機制，大大增加化療的效果。578Please respect copyright.ＰＥＮＡＮＡT8Ea0q63mb
578Please respect copyright.ＰＥＮＡＮＡ1zUqlJRyD0
578Please respect copyright.ＰＥＮＡＮＡTWZmxmRPVg
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。578Please respect copyright.ＰＥＮＡＮＡZ7W8yQ9vKz
578Please respect copyright.ＰＥＮＡＮＡnywxfgQAUE
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc578Please respect copyright.ＰＥＮＡＮＡ8upSc6dZsK
578Please respect copyright.ＰＥＮＡＮＡTGervAiqvb
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。578Please respect copyright.ＰＥＮＡＮＡKXKay4CKac
578Please respect copyright.ＰＥＮＡＮＡBKUC43Rrzi
Link:578Please respect copyright.ＰＥＮＡＮＡ6f2XgtZbgl
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio578Please respect copyright.ＰＥＮＡＮＡfSbCit7onC
578Please respect copyright.ＰＥＮＡＮＡKsxBPkPmGC
578Please respect copyright.ＰＥＮＡＮＡuAOIMxwveC
基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。578Please respect copyright.ＰＥＮＡＮＡ0risYjpLQR
578Please respect copyright.ＰＥＮＡＮＡYlnebyPAO5
Ref1:https://www.nature.com/articles/s41467-020-14928-3578Please respect copyright.ＰＥＮＡＮＡPuvdgxzlvK

ns216.73.217.1da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章