科普專欄–薯不揀單 - 三十秒科學–蛇齋餅糉

癌細胞逃避免疫細胞追殺的手段何其之多，除了較早前提及的PD1/PD1L手段之外，他們亦會用上民建聯蛇齋餅糉的手段應對免疫細胞。484Please respect copyright.ＰＥＮＡＮＡDtA2uQiWMD
484Please respect copyright.ＰＥＮＡＮＡq5I7yE2g7M
484Please respect copyright.ＰＥＮＡＮＡomPbygeGl1
PD1/PD1L手段:https://lih.kg/gzGnLS484Please respect copyright.ＰＥＮＡＮＡKkv7Yp7Tiz
484Please respect copyright.ＰＥＮＡＮＡXw7krgSQX7
484Please respect copyright.ＰＥＮＡＮＡl6UUWnHQRA
（圖2）癌細胞(尤其是腦癌)會表達大量的TDO蛋白酶，TDO蛋白酶會將從外來吸取的氨基酸Tryptophan代謝成為Kynureine;484Please respect copyright.ＰＥＮＡＮＡ2MTNa4sFaU
整個代謝過程是在癌細胞的內部發生。484Please respect copyright.ＰＥＮＡＮＡgg1QihtXVM
484Please respect copyright.ＰＥＮＡＮＡVeyWyzRCcg
484Please respect copyright.ＰＥＮＡＮＡnRKBSxhVrq
（圖3）癌細胞可以自用Kynurenine來觸發AhR蛋白質，輔助自己的生長。484Please respect copyright.ＰＥＮＡＮＡFDZX2gCp1L

484Please respect copyright.ＰＥＮＡＮＡwlacn3Nrvw
同時間，癌細胞亦可將Kynurenine排出四周，而當周遭的免疫細胞吸取Kynurenine後，他們殲滅癌細胞的能力便會下降。484Please respect copyright.ＰＥＮＡＮＡz6DqcLtg9c
484Please respect copyright.ＰＥＮＡＮＡjpYUmYL9hO
亦即是說，當免疫細胞獲取癌細胞所提供的蛇齋餅糉（Kynurenine）後，隨之便會被成功收買，不再侵襲癌細胞。484Please respect copyright.ＰＥＮＡＮＡlJA6fxCjkI
484Please respect copyright.ＰＥＮＡＮＡIFqythS7ki
（圖4）除Kynurenine外，二噁英亦能觸發AhR蛋白質，為癌細胞締造一道美好的生存環境。484Please respect copyright.ＰＥＮＡＮＡUprs0INUsN

484Please respect copyright.ＰＥＮＡＮＡPJDl1fcV2O
484Please respect copyright.ＰＥＮＡＮＡmacPiPWM0M
現今有不少癌症藥物正試圖阻隔AhR蛋白質的觸發來消滅癌症，但亦有證據指出過度阻隔AhR蛋白質有機會反而助長癌細胞的生長，以及引發不良的過敏炎症。484Please respect copyright.ＰＥＮＡＮＡE3gBFX3RaR
484Please respect copyright.ＰＥＮＡＮＡpM9e1JIX1U
除研發阻隔AhR蛋白質藥物外，亦有一道方向是研發藥物減低周遭的Kynurenine濃度，減低癌細胞弱化周遭免疫細胞的能力。484Please respect copyright.ＰＥＮＡＮＡGh4UtpU4Sd
484Please respect copyright.ＰＥＮＡＮＡHTtSNlDTQt
若然成功，或許能配合現有的免疫治療PD1方法加強效果，消滅癌症。484Please respect copyright.ＰＥＮＡＮＡYfqEkSEBZe
484Please respect copyright.ＰＥＮＡＮＡ5ZPRDyQyRH
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。484Please respect copyright.ＰＥＮＡＮＡLnXJekPsDY
484Please respect copyright.ＰＥＮＡＮＡqaOXlEU82b
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc484Please respect copyright.ＰＥＮＡＮＡhqVHnPgTDi
484Please respect copyright.ＰＥＮＡＮＡFOCTjBBKlG
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。484Please respect copyright.ＰＥＮＡＮＡ2l74YWavuF
484Please respect copyright.ＰＥＮＡＮＡRSpBssXIKz
Link:484Please respect copyright.ＰＥＮＡＮＡG6snWay0Ia
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio484Please respect copyright.ＰＥＮＡＮＡqvLzFk1kS2
484Please respect copyright.ＰＥＮＡＮＡa4m5hlY1MV
484Please respect copyright.ＰＥＮＡＮＡhOT035RJVi
基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。484Please respect copyright.ＰＥＮＡＮＡwIj9y5gfTg
484Please respect copyright.ＰＥＮＡＮＡ19WDR854ri
Ref1:https://www.nature.com/articles/nature10491484Please respect copyright.ＰＥＮＡＮＡZa6WL9TaXd
Ref2:https://www.sciencedirect.com/science/article/pii/S0165614717302249484Please respect copyright.ＰＥＮＡＮＡi5jf9E57A3

ns216.73.217.1da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章