透過進食,我們能夠從食物中獲取身體所需的能量。這過程亦稱之為新陳代謝。258Please respect copyright.PENANAricxH9e3Pi
258Please respect copyright.PENANAC6bl2yLwBD
258Please respect copyright.PENANA4aTq3GUcfT
有無數證據顯示,癌細胞的新陳代謝與正常的細胞有著顯著的分別。258Please respect copyright.PENANAK4CGbGmMd6
正因如此,有不少科學家抱有一個信念,希望透過針對癌細胞的新陳代謝來抑止癌細胞的生長,甚至是達消滅癌細胞之效。258Please respect copyright.PENANAhnKRWy30Hq
258Please respect copyright.PENANAXaKHkIwYsl
(圖2)半胱胺酸 (Cysteine)是氨基酸的一種,亦即是組成蛋白質的基本單元。258Please respect copyright.PENANAgeAxSkl2yK
258Please respect copyright.PENANApZZCXZjXPd
258Please respect copyright.PENANA5mbRrjbVqz
我們可以透過直接進食來攝取Cysteine,又或者依靠肝臟將特定兩隻氨基酸(Methionine及Serine)轉化成為Cysteine供我們所用。258Please respect copyright.PENANAYB5dyBZIvw
258Please respect copyright.PENANANLHoEklAoh
有科學家嘗試從飼養癌細胞的營養液中剔除Cysteine,發覺部份癌細胞的生長速度有所減慢,而有部份的癌細胞則趨向死亡(Ref1)。258Please respect copyright.PENANASl5S4HM78q
258Please respect copyright.PENANA7a5uYAsYRa
(圖3)從營養液剔除Cysteine後,身體攝取Cysteine的辦法便只剩下依靠肝臟將同為氨基酸的Methionine及Serine轉化成為Cysteine。258Please respect copyright.PENANAK594sIX5eT
258Please respect copyright.PENANAgVZCk5bYca
258Please respect copyright.PENANArAkoiQBQkL
而各種剔除Cysteine便會死亡的癌細胞的共通點,就是缺乏一隻名為5-methylthioadenosine phosphorylase(MTAP)的蛋白酶。258Please respect copyright.PENANAjlVkSyb2pZ
258Please respect copyright.PENANAsASagSpmxV
失去MTAP後,細胞會傾向將Methionine轉化成為一系列名為Polyamine的物質,導致身體失去製作Cysteine的手段。258Please respect copyright.PENANAx7XN8FdUxT
258Please respect copyright.PENANAYLwtWxtJya
更甚的是,產生Polyamine的過程中將會產生游離基,而制衡游離基的Glutathione卻則依靠Cysteine作為原材料。258Please respect copyright.PENANAQLaKF4Dx7t
258Please respect copyright.PENANAcGSDmM4fnh
因此,缺乏MTAP的癌細胞若然沒有外來Cysteine供應的話,便會因游離基數量過多而導致死亡。258Please respect copyright.PENANA9f6MbAPT65
258Please respect copyright.PENANAqqzo8Qhkwp
環觀各種癌細胞,膠質母細胞瘤(Glioblastoma)有較大的機會因基因變異而失去MTAP基因。258Please respect copyright.PENANAthH3i5iCAM
258Please respect copyright.PENANAL2WJ9aIp8s
根據上述研究結果,若癌症病人的癌細胞證實缺乏MTAP基因的話,在餐單中剔除進食Cysteine氨基酸或許是一個副作用相對上為微的理性選擇。258Please respect copyright.PENANACColxuRjkw
258Please respect copyright.PENANA0W6ypX55bs
258Please respect copyright.PENANAbhjBvMn3gu
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。258Please respect copyright.PENANADAyLd3yBeN
258Please respect copyright.PENANABHO9k65jrL
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc258Please respect copyright.PENANAgnnbfhATE7
258Please respect copyright.PENANALrODwJJZVN
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。258Please respect copyright.PENANAwYtHtFaOQJ
258Please respect copyright.PENANAKeZZg70aK2
Link:258Please respect copyright.PENANA4iFtSwk6ZO
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio258Please respect copyright.PENANA33UQ4Zqlky
258Please respect copyright.PENANAf11UJNWrm2
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。258Please respect copyright.PENANAI800L5gQcN
258Please respect copyright.PENANAnSiauH1vbB
https://www.instagram.com/potatopigtongue/258Please respect copyright.PENANASZ3qv0t52C
258Please respect copyright.PENANAr1bxMa61sE
258Please respect copyright.PENANAXn1WnDObma
Ref1:https://www.nature.com/articles/s42255-020-0253-2
arrow_back
科普專欄–薯不揀單
more_vert
-
info_outline Info
-
toc Table of Contents
-
share Share
-
format_color_text Display Settings
-
exposure_plus_1 Recommend
-
Sponsor
-
report_problem Report
-
account_circle Login
Search stories, writers or societies
Continue ReadingClear All
What Others Are ReadingRefresh
X
Never miss what's happening on Penana!
科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #127
深入淺出–針對新陳代謝來醫治癌症(一)
LIKES 1
READS 254
BOOKMARKS 148
campaign
Request update 0
Sponsor
Login with Facebook
or Sign up/Login to comment or bookmark!
Click to load the next chapter
X
After each update request, the author will receive a notification!
smartphone100 → Request update
X
Sponsor again
Click to login
Login first to show your name as a sponsor.
Thank you for supporting the story! :)
Please Login first.
×
Write down what you like about the story
×
Reading Theme:
Font Size:
Line Spacing:
Paragraph Spacing:
Load the next issue automatically
Reset to default
×
People Who Like This