透過進食,我們能夠從食物中獲取身體所需的能量。這過程亦稱之為新陳代謝。268Please respect copyright.PENANAqQeYIbIQY0
268Please respect copyright.PENANAtJ0imPrjAC
268Please respect copyright.PENANAadPBiVibCp
有無數證據顯示,癌細胞的新陳代謝與正常的細胞有著顯著的分別。268Please respect copyright.PENANAqPfrgajFTv
正因如此,有不少科學家抱有一個信念,希望透過針對癌細胞的新陳代謝來抑止癌細胞的生長,甚至是達消滅癌細胞之效。268Please respect copyright.PENANAON3dXokGKP
268Please respect copyright.PENANAYKYpme0WIX
(圖2)半胱胺酸 (Cysteine)是氨基酸的一種,亦即是組成蛋白質的基本單元。268Please respect copyright.PENANAMxXoPRsu87
268Please respect copyright.PENANAABQYT4iYFC
268Please respect copyright.PENANAYQma8Je2S5
我們可以透過直接進食來攝取Cysteine,又或者依靠肝臟將特定兩隻氨基酸(Methionine及Serine)轉化成為Cysteine供我們所用。268Please respect copyright.PENANAMdlAljzHMH
268Please respect copyright.PENANAZxhn9EMaNo
有科學家嘗試從飼養癌細胞的營養液中剔除Cysteine,發覺部份癌細胞的生長速度有所減慢,而有部份的癌細胞則趨向死亡(Ref1)。268Please respect copyright.PENANAy6e96E3wKY
268Please respect copyright.PENANAvTUgkoewxV
(圖3)從營養液剔除Cysteine後,身體攝取Cysteine的辦法便只剩下依靠肝臟將同為氨基酸的Methionine及Serine轉化成為Cysteine。268Please respect copyright.PENANAgRq1iY7InM
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而各種剔除Cysteine便會死亡的癌細胞的共通點,就是缺乏一隻名為5-methylthioadenosine phosphorylase(MTAP)的蛋白酶。268Please respect copyright.PENANA3IluD4sH2Z
268Please respect copyright.PENANACPTeyoxO7Y
失去MTAP後,細胞會傾向將Methionine轉化成為一系列名為Polyamine的物質,導致身體失去製作Cysteine的手段。268Please respect copyright.PENANA7LKaQ0WJ9C
268Please respect copyright.PENANAliALEUW5jn
更甚的是,產生Polyamine的過程中將會產生游離基,而制衡游離基的Glutathione卻則依靠Cysteine作為原材料。268Please respect copyright.PENANA5IsDsYyqVN
268Please respect copyright.PENANArRC5p08Sv1
因此,缺乏MTAP的癌細胞若然沒有外來Cysteine供應的話,便會因游離基數量過多而導致死亡。268Please respect copyright.PENANAIG35gKAFN3
268Please respect copyright.PENANA9I6N8xxRNV
環觀各種癌細胞,膠質母細胞瘤(Glioblastoma)有較大的機會因基因變異而失去MTAP基因。268Please respect copyright.PENANAGBso23DDeP
268Please respect copyright.PENANA9CJ5RfiT73
根據上述研究結果,若癌症病人的癌細胞證實缺乏MTAP基因的話,在餐單中剔除進食Cysteine氨基酸或許是一個副作用相對上為微的理性選擇。268Please respect copyright.PENANAaQQMAXr7ai
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268Please respect copyright.PENANAwumbOR7rhW
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。268Please respect copyright.PENANAtoRZbSx4iK
268Please respect copyright.PENANA5MAPPvukOy
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc268Please respect copyright.PENANARvNqkuYrbi
268Please respect copyright.PENANAwn9xPn4JFy
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。268Please respect copyright.PENANAP8tMX25CAb
268Please respect copyright.PENANAu5gYg8KDir
Link:268Please respect copyright.PENANAxILvCggDfp
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio268Please respect copyright.PENANARmmdYwJxYP
268Please respect copyright.PENANAfcbL0VEBUb
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。268Please respect copyright.PENANA9CiYkAOMXN
268Please respect copyright.PENANALXfUkfGtFz
https://www.instagram.com/potatopigtongue/268Please respect copyright.PENANAXx8yI1LaHt
268Please respect copyright.PENANASbubtzZpRj
268Please respect copyright.PENANArWZRQvKcdD
Ref1:https://www.nature.com/articles/s42255-020-0253-2
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科普專欄–薯不揀單
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薯仔聞茱莉
篇 #127
深入淺出–針對新陳代謝來醫治癌症(一)
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