透過進食,我們能夠從食物中獲取身體所需的能量。這過程亦稱之為新陳代謝。536Please respect copyright.PENANAvwCNjyPCR8536Please respect copyright.PENANAsASqUUNG7x
536Please respect copyright.PENANAWxss8RRvIi
有無數證據顯示,癌細胞的新陳代謝與正常的細胞有著顯著的分別。536Please respect copyright.PENANAJUSn1RQqdt
正因如此,有不少科學家抱有一個信念,希望透過針對癌細胞的新陳代謝來抑止癌細胞的生長,甚至是達消滅癌細胞之效。536Please respect copyright.PENANA8CDsmemosX
536Please respect copyright.PENANAyU7xdsFpxC
(圖2)半胱胺酸 (Cysteine)是氨基酸的一種,亦即是組成蛋白質的基本單元。536Please respect copyright.PENANAc5YMRkDRnm536Please respect copyright.PENANASUX5lC9wX9
536Please respect copyright.PENANAJjy00ESmNi
我們可以透過直接進食來攝取Cysteine,又或者依靠肝臟將特定兩隻氨基酸(Methionine及Serine)轉化成為Cysteine供我們所用。536Please respect copyright.PENANAU9SQ3Ldqgf
536Please respect copyright.PENANAFbZCGhOhDo
有科學家嘗試從飼養癌細胞的營養液中剔除Cysteine,發覺部份癌細胞的生長速度有所減慢,而有部份的癌細胞則趨向死亡(Ref1)。536Please respect copyright.PENANAYPKLrq7tyV
536Please respect copyright.PENANAagUuHDvU4G
(圖3)從營養液剔除Cysteine後,身體攝取Cysteine的辦法便只剩下依靠肝臟將同為氨基酸的Methionine及Serine轉化成為Cysteine。536Please respect copyright.PENANA9gCeiMFOta536Please respect copyright.PENANA6EoY9P9WYp
536Please respect copyright.PENANAmp1PYykbHY
而各種剔除Cysteine便會死亡的癌細胞的共通點,就是缺乏一隻名為5-methylthioadenosine phosphorylase(MTAP)的蛋白酶。536Please respect copyright.PENANA4NdRXt6Pyj
536Please respect copyright.PENANACtZeyPkU2j
失去MTAP後,細胞會傾向將Methionine轉化成為一系列名為Polyamine的物質,導致身體失去製作Cysteine的手段。536Please respect copyright.PENANAE3DsYhE8Kj
536Please respect copyright.PENANAYUI1fu6wBz
更甚的是,產生Polyamine的過程中將會產生游離基,而制衡游離基的Glutathione卻則依靠Cysteine作為原材料。536Please respect copyright.PENANAbnPd26HdYu
536Please respect copyright.PENANA0VYhxUcKnj
因此,缺乏MTAP的癌細胞若然沒有外來Cysteine供應的話,便會因游離基數量過多而導致死亡。536Please respect copyright.PENANA0j4VH6Egqk
536Please respect copyright.PENANAZAcVxkJWGt
環觀各種癌細胞,膠質母細胞瘤(Glioblastoma)有較大的機會因基因變異而失去MTAP基因。536Please respect copyright.PENANAYffHl9dQ3E
536Please respect copyright.PENANAhqCBYq5FVW
根據上述研究結果,若癌症病人的癌細胞證實缺乏MTAP基因的話,在餐單中剔除進食Cysteine氨基酸或許是一個副作用相對上為微的理性選擇。536Please respect copyright.PENANAPoqp699oZ1
536Please respect copyright.PENANAmhN35lXsJD
536Please respect copyright.PENANAyAsNprWgT1
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。536Please respect copyright.PENANAxUj6iF1cHM
536Please respect copyright.PENANAf18cjJhRnU
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc536Please respect copyright.PENANAf7Ra6AoAJr
536Please respect copyright.PENANAIc8PimW6Mx
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。536Please respect copyright.PENANAMpaR8emTff
536Please respect copyright.PENANAlFY7uvyour
Link:536Please respect copyright.PENANAABtDBPkdrn
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio536Please respect copyright.PENANA0Zq0MfreO5
536Please respect copyright.PENANA9cGHSSj5Yi
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。536Please respect copyright.PENANAVnsredNEac
536Please respect copyright.PENANAtWeEzyDYLI
https://www.instagram.com/potatopigtongue/536Please respect copyright.PENANA0hbYCdv50K
536Please respect copyright.PENANAKKP03HIjCr
536Please respect copyright.PENANAVSKPVC6ozg
Ref1:https://www.nature.com/articles/s42255-020-0253-2
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科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #127
深入淺出–針對新陳代謝來醫治癌症(一)
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