透過進食，我們能夠從食物中獲取身體所需的能量。這過程亦稱之為新陳代謝。438Please respect copyright.ＰＥＮＡＮＡizA46HrYtr
438Please respect copyright.ＰＥＮＡＮＡxjSxR2IG5w
438Please respect copyright.ＰＥＮＡＮＡZ2AAmpUA3V
有無數證據顯示，癌細胞的新陳代謝與正常的細胞有著顯著的分別。438Please respect copyright.ＰＥＮＡＮＡaQoL9KI2ve
正因如此，有不少科學家抱有一個信念，希望透過針對癌細胞的新陳代謝來抑止癌細胞的生長，甚至是達消滅癌細胞之效。438Please respect copyright.ＰＥＮＡＮＡXBF2FDl3FH
438Please respect copyright.ＰＥＮＡＮＡlAwnqTPILt
（圖2）半胱胺酸 (Cysteine)是氨基酸的一種，亦即是組成蛋白質的基本單元。438Please respect copyright.ＰＥＮＡＮＡ3qgiQ59AQX
438Please respect copyright.ＰＥＮＡＮＡiZCXjjiK1O
438Please respect copyright.ＰＥＮＡＮＡkj8GGCrazY
我們可以透過直接進食來攝取Cysteine，又或者依靠肝臟將特定兩隻氨基酸(Methionine及Serine)轉化成為Cysteine供我們所用。438Please respect copyright.ＰＥＮＡＮＡMYGm84v3H4
438Please respect copyright.ＰＥＮＡＮＡpEA4wpKOI1
有科學家嘗試從飼養癌細胞的營養液中剔除Cysteine，發覺部份癌細胞的生長速度有所減慢，而有部份的癌細胞則趨向死亡(Ref1)。438Please respect copyright.ＰＥＮＡＮＡ979r1qCqbb
438Please respect copyright.ＰＥＮＡＮＡV1PvIad1fB
（圖3）從營養液剔除Cysteine後，身體攝取Cysteine的辦法便只剩下依靠肝臟將同為氨基酸的Methionine及Serine轉化成為Cysteine。438Please respect copyright.ＰＥＮＡＮＡ27bv8fSYJH
438Please respect copyright.ＰＥＮＡＮＡoQD8Q6pONm
438Please respect copyright.ＰＥＮＡＮＡgKCXvjDZOb
而各種剔除Cysteine便會死亡的癌細胞的共通點，就是缺乏一隻名為5-methylthioadenosine phosphorylase(MTAP)的蛋白酶。438Please respect copyright.ＰＥＮＡＮＡxLen4RWEdb
438Please respect copyright.ＰＥＮＡＮＡ4ZNsTYWElz
失去MTAP後，細胞會傾向將Methionine轉化成為一系列名為Polyamine的物質，導致身體失去製作Cysteine的手段。438Please respect copyright.ＰＥＮＡＮＡ1VGqdwBRxR
438Please respect copyright.ＰＥＮＡＮＡZFBtvKJ5Ku
更甚的是，產生Polyamine的過程中將會產生游離基，而制衡游離基的Glutathione卻則依靠Cysteine作為原材料。438Please respect copyright.ＰＥＮＡＮＡDBeqUssuZq
438Please respect copyright.ＰＥＮＡＮＡVA1mHyxtep
因此，缺乏MTAP的癌細胞若然沒有外來Cysteine供應的話，便會因游離基數量過多而導致死亡。438Please respect copyright.ＰＥＮＡＮＡH5zCDCpX5V
438Please respect copyright.ＰＥＮＡＮＡ22q7rxXe0X
環觀各種癌細胞，膠質母細胞瘤（Glioblastoma)有較大的機會因基因變異而失去MTAP基因。438Please respect copyright.ＰＥＮＡＮＡsxoqzpYa8P
438Please respect copyright.ＰＥＮＡＮＡh5iuxUshZB
根據上述研究結果，若癌症病人的癌細胞證實缺乏MTAP基因的話，在餐單中剔除進食Cysteine氨基酸或許是一個副作用相對上為微的理性選擇。438Please respect copyright.ＰＥＮＡＮＡFo4Y7R3OIF
438Please respect copyright.ＰＥＮＡＮＡ15js5WpUZY
438Please respect copyright.ＰＥＮＡＮＡMEQ45sU88m
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。438Please respect copyright.ＰＥＮＡＮＡraNe8Sm2zD
438Please respect copyright.ＰＥＮＡＮＡGABQxuK8T0
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc438Please respect copyright.ＰＥＮＡＮＡHeQk5P0PIX
438Please respect copyright.ＰＥＮＡＮＡlkqa2MmJob
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。438Please respect copyright.ＰＥＮＡＮＡus09ZySEtv
438Please respect copyright.ＰＥＮＡＮＡl6G2hQFxll
Link:438Please respect copyright.ＰＥＮＡＮＡFYKQp1klnj
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio438Please respect copyright.ＰＥＮＡＮＡKPhiYj7Q73
438Please respect copyright.ＰＥＮＡＮＡNiPyQ4Spg3
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。438Please respect copyright.ＰＥＮＡＮＡKgQmYbzoyG
438Please respect copyright.ＰＥＮＡＮＡ3Tuncubo7J
https://www.instagram.com/potatopigtongue/438Please respect copyright.ＰＥＮＡＮＡ9D5wPhhQzI
438Please respect copyright.ＰＥＮＡＮＡFJyHXTjywH
438Please respect copyright.ＰＥＮＡＮＡp8748l7he1
Ref1:https://www.nature.com/articles/s42255-020-0253-28964 copyright protection434ＰＥＮＡＮＡDhe7BEYMoA 維尼

3.128.203.120