透過進食,我們能夠從食物中獲取身體所需的能量。這過程亦稱之為新陳代謝。483Please respect copyright.PENANATp7ckQxsYz483Please respect copyright.PENANAnTARvtvwIO
483Please respect copyright.PENANAzZlURyJn3h
有無數證據顯示,癌細胞的新陳代謝與正常的細胞有著顯著的分別。483Please respect copyright.PENANAK26uzjvb2r
正因如此,有不少科學家抱有一個信念,希望透過針對癌細胞的新陳代謝來抑止癌細胞的生長,甚至是達消滅癌細胞之效。483Please respect copyright.PENANA4hMR2BHMZP
483Please respect copyright.PENANA6DT05MiaGU
(圖2)半胱胺酸 (Cysteine)是氨基酸的一種,亦即是組成蛋白質的基本單元。483Please respect copyright.PENANAfENytyLvxZ483Please respect copyright.PENANAQq9bGDxYir
483Please respect copyright.PENANAhdqtVr8hkP
我們可以透過直接進食來攝取Cysteine,又或者依靠肝臟將特定兩隻氨基酸(Methionine及Serine)轉化成為Cysteine供我們所用。483Please respect copyright.PENANA3ykPvRFw6Q
483Please respect copyright.PENANAOngL18n4JH
有科學家嘗試從飼養癌細胞的營養液中剔除Cysteine,發覺部份癌細胞的生長速度有所減慢,而有部份的癌細胞則趨向死亡(Ref1)。483Please respect copyright.PENANAbwUzxnTQ2L
483Please respect copyright.PENANAJkE3JIVuQC
(圖3)從營養液剔除Cysteine後,身體攝取Cysteine的辦法便只剩下依靠肝臟將同為氨基酸的Methionine及Serine轉化成為Cysteine。483Please respect copyright.PENANATpOqk27n6K483Please respect copyright.PENANAmCdyKGWrAP
483Please respect copyright.PENANA4DuulklPPZ
而各種剔除Cysteine便會死亡的癌細胞的共通點,就是缺乏一隻名為5-methylthioadenosine phosphorylase(MTAP)的蛋白酶。483Please respect copyright.PENANAExnyyc9SFZ
483Please respect copyright.PENANADfh063Gk2x
失去MTAP後,細胞會傾向將Methionine轉化成為一系列名為Polyamine的物質,導致身體失去製作Cysteine的手段。483Please respect copyright.PENANArsztlc7ecB
483Please respect copyright.PENANA0Q2irMRZ7f
更甚的是,產生Polyamine的過程中將會產生游離基,而制衡游離基的Glutathione卻則依靠Cysteine作為原材料。483Please respect copyright.PENANAlZKGT8sUCy
483Please respect copyright.PENANAfzR5Wu1fqF
因此,缺乏MTAP的癌細胞若然沒有外來Cysteine供應的話,便會因游離基數量過多而導致死亡。483Please respect copyright.PENANAi7DvaMbfH5
483Please respect copyright.PENANAmSPs6Fy7PW
環觀各種癌細胞,膠質母細胞瘤(Glioblastoma)有較大的機會因基因變異而失去MTAP基因。483Please respect copyright.PENANAsevh3zYzo3
483Please respect copyright.PENANA5NmCse5Qbx
根據上述研究結果,若癌症病人的癌細胞證實缺乏MTAP基因的話,在餐單中剔除進食Cysteine氨基酸或許是一個副作用相對上為微的理性選擇。483Please respect copyright.PENANAQsVlzeO0y0
483Please respect copyright.PENANANPtl4DYVF7
483Please respect copyright.PENANA8zagS87b2I
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。483Please respect copyright.PENANAfGB6sizfcS
483Please respect copyright.PENANAZVq7Kx5eSw
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc483Please respect copyright.PENANAAK7ckkMVL5
483Please respect copyright.PENANA4g3Lr9lOhM
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。483Please respect copyright.PENANAelDxNWEYff
483Please respect copyright.PENANA18MjwkL3F3
Link:483Please respect copyright.PENANAONiFjXzh5O
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio483Please respect copyright.PENANAOVrJnBH0S5
483Please respect copyright.PENANA2XUmnhSKcD
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。483Please respect copyright.PENANAoSF0vunA98
483Please respect copyright.PENANAZRUNxNg3J0
https://www.instagram.com/potatopigtongue/483Please respect copyright.PENANAIJ9A0amoBf
483Please respect copyright.PENANAl1qu6JDxku
483Please respect copyright.PENANAKtaRjQu7G0
Ref1:https://www.nature.com/articles/s42255-020-0253-2
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科普專欄–薯不揀單
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薯仔聞茱莉

篇 #127
深入淺出–針對新陳代謝來醫治癌症(一)
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