腸道是細菌們聚居體內的其中一道地方,而腸道細菌品種的變異,將有助大腸癌的形成。750Please respect copyright.PENANAykes2vlQm3750Please respect copyright.PENANAkFj05TQdUJ
750Please respect copyright.PENANAZgWDdaa42U
(圖2)糞便含有腸道的細菌,透過糞便移植(其中一方法為從口中灌入),人類腸道的細菌亦因而能夠寄居到老鼠腸道中。750Please respect copyright.PENANAF4G8rACnWV750Please respect copyright.PENANAfodq8ey2R2
750Please respect copyright.PENANAU4H3RD2XSH
就此,有科學家嘗試將健康人士及腸癌病人的糞便移植到老鼠腸道中,探索腸道細菌對大腸癌的影響(Ref1)。750Please respect copyright.PENANAlj6IWjaeio
750Please respect copyright.PENANAPnErk8GPIU
(圖3)從圖中可見,莫論是健康還是腸癌人士糞便組別也好,普通老鼠均不會出現腸癌。750Please respect copyright.PENANA3NXXnJSbCk750Please respect copyright.PENANArQLGqk6Nqy
750Please respect copyright.PENANATH2D0zD095
但在天生容易生腸癌的老鼠中,移植腸癌人士糞便後所出現的腫瘤數量,明顯的比健康人士糞便組別為多。750Please respect copyright.PENANAofzdDHh06E
750Please respect copyright.PENANAGU9j6aX6Ug
(圖4)同時,移植腸癌人士糞便後所出現的腫瘤,體積亦明顯的比健康人士糞便組別為大。750Please respect copyright.PENANAUsidAkMWKL750Please respect copyright.PENANA9pXKU5kBoN
750Please respect copyright.PENANA8JVN2L7EPc
而移植糞便後,兩組老鼠的腸道細菌品種亦有明顯分別。750Please respect copyright.PENANAxIfmixN1VD
750Please respect copyright.PENANAI3FkDczj0z
(圖5)重要的是,腸癌人士糞便中的某幾隻脂肪酸數量,亦明顯比健康人士糞便組別為少。750Please respect copyright.PENANAUYre71PYZz
750Please respect copyright.PENANAbyHqkgpdRb
750Please respect copyright.PENANAUSNOAxwc5m
依照現時的理論,人體有部份的腸道細菌乃依靠消化食用纖維維生。750Please respect copyright.PENANA9EVL42mcA9
750Please respect copyright.PENANAswmpqkiJOr
當人體長期沒有進食纖維的話,將會導致腸道細菌品種失衡,使進食脂肪酸的細菌品種助大。750Please respect copyright.PENANAVBsnE2mWIb
750Please respect copyright.PENANARDOX6kVoBo
這亦有可能解釋得到,為何腸癌人士糞便中某數款脂肪酸的數量亦相對之為少。750Please respect copyright.PENANA7BwPXjfJX3
750Please respect copyright.PENANAMNN9W3TkCx
基於腸道細菌品種與大腸癌的形成有著密切關係,有不少研究團隊亦開始研究如何透過檢測糞便的細菌品種來推算出大腸癌的出現機率,與內窺鏡檢查相輔相成。750Please respect copyright.PENANAnFXFi52eBJ
750Please respect copyright.PENANATxaMmhryUA
750Please respect copyright.PENANAWg8t6Z7D42
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。750Please respect copyright.PENANAV6rEeNWuDX
750Please respect copyright.PENANAhQJ2wXAwTO
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc750Please respect copyright.PENANA9ZgxIJKksL
750Please respect copyright.PENANAEERnPjcaGb
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。750Please respect copyright.PENANAJKOCTWrzIt
750Please respect copyright.PENANAuxklzXhitE
Link:750Please respect copyright.PENANATV9RVplZTI
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio750Please respect copyright.PENANArZ0RSP2WxL
750Please respect copyright.PENANAqgBmXpLOyc
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。750Please respect copyright.PENANAxuXyUGLskQ
750Please respect copyright.PENANAjT1KKMvbYW
https://www.instagram.com/potatopigtongue/750Please respect copyright.PENANAhCV1SLtTJO
750Please respect copyright.PENANADPcmYP6y97
750Please respect copyright.PENANACRZfDgDW4c
Ref1:https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30625-5/fulltext750Please respect copyright.PENANAGKwnKhcYQk
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科普專欄–薯不揀單
Author:
薯仔聞茱莉

ISSUE #126
深入淺出–腸道細菌與大腸癌
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