往不同動物例如老鼠及線蟲注射治療糖尿病的藥物(Metformin)後,壽命均會有顯著的增長。426Please respect copyright.PENANA6XiudmT0zu426Please respect copyright.PENANAYjKoNNTUzG
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有研究利用現成資料庫作對比,發現服用Metformin的糖尿病人歲數比沒有服用Metformin的健康人士為長(Ref1),亦有臨床研究嘗試為14名70歲的健康老人家注射為期6星期的Metformin,藉觀察體內的轉變以作抗衰老藥的研究基礎(Ref2)。426Please respect copyright.PENANAoo3ZrRUV6r
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(圖2)從圖中可見,往年輕線蟲注射Metformin的話,牠們的生存日子便會增長。426Please respect copyright.PENANAmFVKKu9oSS426Please respect copyright.PENANAJXUvLxO3TO
426Please respect copyright.PENANAcq4N0iIVFi
(圖3)但是,與年輕線蟲相反,往年老的線蟲注射Metformin的話,牠們的生存日子不但沒有增加,反而會減少。426Please respect copyright.PENANACdKsN8CEJN426Please respect copyright.PENANA7Vu6Tra4Uy
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(圖4)經過一系列的實驗,科學家認為Metformin能夠驅使年輕線蟲延壽的其中一個原因,是與粒線體的整體功用有關(Ref3)。426Please respect copyright.PENANA0BXwfj97cy426Please respect copyright.PENANABdc4p3BZLC
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其中,Metformin為年輕線蟲的新陳代謝作出轉變,包括增加碳水化合物的分解,減低脂肪的含量等,但年老的線蟲卻沒能夠觸發同樣的效果,反而更會因新陳代謝機制的不良負荷而增加死亡率。426Please respect copyright.PENANAhO7AE1IoDO
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文中的科學家亦就此作出質疑,既然Metformin只能使年輕線蟲而非年老線蟲延壽,那又究竟是否值得「魯莽」地對健康老人家進行Metformin的延壽研究。426Please respect copyright.PENANA9P4veSs3kO
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。426Please respect copyright.PENANA8riJurJmvi
426Please respect copyright.PENANArMqo7BqOSD
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc426Please respect copyright.PENANAPAjALgNnaw
426Please respect copyright.PENANAOJnC8EONKi
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。426Please respect copyright.PENANAVozEiMvzo2
426Please respect copyright.PENANAL3pVKpJK6m
Link:426Please respect copyright.PENANA5ZquB8Y66q
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio426Please respect copyright.PENANAam1tQkSYoN
426Please respect copyright.PENANAKJlrTbpj9J
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。426Please respect copyright.PENANANbyig9JzTm
426Please respect copyright.PENANAuvATtarWMr
https://www.instagram.com/potatopigtongue/426Please respect copyright.PENANA6PHFMmz0RF
426Please respect copyright.PENANAzd8m64uNfW
426Please respect copyright.PENANAuEqjFuW0mH
426Please respect copyright.PENANA5kaMCJYffk
426Please respect copyright.PENANAcA2KMZ5Wbt
Ref1:https://pubmed.ncbi.nlm.nih.gov/25041462/426Please respect copyright.PENANAJNSymhDw0P
Ref2:https://pubmed.ncbi.nlm.nih.gov/29383869/426Please respect copyright.PENANA1qtFZSZ8pO
Ref3:https://www.nature.com/articles/s42255-020-00307-1426Please respect copyright.PENANAoiAHrD0Fp5
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科普專欄–薯不揀單
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薯仔聞茱莉
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ISSUE #125
深入淺出–延壽藥物的研究(一)
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