往不同動物例如老鼠及線蟲注射治療糖尿病的藥物(Metformin)後,壽命均會有顯著的增長。721Please respect copyright.PENANALrs02oZYc1721Please respect copyright.PENANAUzm2vZXMit
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有研究利用現成資料庫作對比,發現服用Metformin的糖尿病人歲數比沒有服用Metformin的健康人士為長(Ref1),亦有臨床研究嘗試為14名70歲的健康老人家注射為期6星期的Metformin,藉觀察體內的轉變以作抗衰老藥的研究基礎(Ref2)。721Please respect copyright.PENANApQPKIgCyIZ
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(圖2)從圖中可見,往年輕線蟲注射Metformin的話,牠們的生存日子便會增長。721Please respect copyright.PENANAsMGhoVTAWa721Please respect copyright.PENANAU00K4zOoVt
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(圖3)但是,與年輕線蟲相反,往年老的線蟲注射Metformin的話,牠們的生存日子不但沒有增加,反而會減少。721Please respect copyright.PENANAZS67Tr6zb9721Please respect copyright.PENANAkyxC3Sy0PE
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(圖4)經過一系列的實驗,科學家認為Metformin能夠驅使年輕線蟲延壽的其中一個原因,是與粒線體的整體功用有關(Ref3)。721Please respect copyright.PENANA55O0ipB9GV721Please respect copyright.PENANAc5PETL43ux
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其中,Metformin為年輕線蟲的新陳代謝作出轉變,包括增加碳水化合物的分解,減低脂肪的含量等,但年老的線蟲卻沒能夠觸發同樣的效果,反而更會因新陳代謝機制的不良負荷而增加死亡率。721Please respect copyright.PENANAuNc8UCKSUr
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文中的科學家亦就此作出質疑,既然Metformin只能使年輕線蟲而非年老線蟲延壽,那又究竟是否值得「魯莽」地對健康老人家進行Metformin的延壽研究。721Please respect copyright.PENANAd7ZSJcJm77
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。721Please respect copyright.PENANA5qfx4PWSqo
721Please respect copyright.PENANAJQYxm5Z0Vm
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc721Please respect copyright.PENANAbqjeq3jTbV
721Please respect copyright.PENANAfbo8QxUiOd
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。721Please respect copyright.PENANA5ee8Jdx4RD
721Please respect copyright.PENANAoe4NwxNOZc
Link:721Please respect copyright.PENANAyY3ArBgIxQ
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio721Please respect copyright.PENANA7g569Q5ZFk
721Please respect copyright.PENANAxnh3tbXH8j
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。721Please respect copyright.PENANAwS157Aj0Kf
721Please respect copyright.PENANAgip8JI7HSc
https://www.instagram.com/potatopigtongue/721Please respect copyright.PENANA29pGlH7Hgc
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721Please respect copyright.PENANAsu7iQIJeZk
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Ref1:https://pubmed.ncbi.nlm.nih.gov/25041462/721Please respect copyright.PENANAS3htKv2ii6
Ref2:https://pubmed.ncbi.nlm.nih.gov/29383869/721Please respect copyright.PENANAncA2JUwP9q
Ref3:https://www.nature.com/articles/s42255-020-00307-1721Please respect copyright.PENANAuhW9qqotsI
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科普專欄–薯不揀單
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薯仔聞茱莉

篇 #125
深入淺出–延壽藥物的研究(一)
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