科普專欄–薯不揀單 - 三十秒科學–潛伏在另一器官的癌細胞

癌細胞從原處走到另一地方(轉移，Metastasis)，均需透過血液或淋巴系統作交通渠道。610Please respect copyright.ＰＥＮＡＮＡrcbHjhhfSa
610Please respect copyright.ＰＥＮＡＮＡBFD8r9HiJJ
610Please respect copyright.ＰＥＮＡＮＡe1i0LuSRDl
有不少癌細胞轉移到另一器官後會呈「休養」狀態，不迅速繁殖，而是長期潛伏在另一器官內。610Please respect copyright.ＰＥＮＡＮＡQIUhlLCuTI
610Please respect copyright.ＰＥＮＡＮＡj0K1RXpawa
因此就算沒能檢測得到循環腫瘤細胞的存在，也不百分百等於未來不會出現癌細胞轉移事件。610Please respect copyright.ＰＥＮＡＮＡI0l8HBN01t
610Please respect copyright.ＰＥＮＡＮＡlbTJxHzGyZ
610Please respect copyright.ＰＥＮＡＮＡIhHbco8HPI
(圖2)科學家分別把人類及老鼠的癌細胞注入到老鼠模型作研究，發現癌細胞發生轉移的機率是與目的地所含的NK cell數量有關係。610Please respect copyright.ＰＥＮＡＮＡIdvWnLty5v
610Please respect copyright.ＰＥＮＡＮＡ3HPQc91sjy
610Please respect copyright.ＰＥＮＡＮＡRcD7kuFyqA
目的地所含的NK cell越多，該地方出現癌細胞轉移的機率亦會越低。610Please respect copyright.ＰＥＮＡＮＡSEK78bAKPu
610Please respect copyright.ＰＥＮＡＮＡL1zmpyBx3q
之所以會出現這情況，除了是NK cell殺死癌細胞這可能性之外，科學家發現NK cell會釋放interferon-γ (IFN-γ)的物質，誘使癌細胞進入休養狀態，不進行自我繁殖。610Please respect copyright.ＰＥＮＡＮＡQG61ry3yTS
610Please respect copyright.ＰＥＮＡＮＡHBTUoI0D9k
610Please respect copyright.ＰＥＮＡＮＡu7x20RmZZy
(圖3)奈何，至少在肝臟裡頭，一種名為Hepatic stellate cells會釋出CXCL12物質，CXCL12會阻礙NK cell的生長速度。610Please respect copyright.ＰＥＮＡＮＡ4GTqHwsg4X
610Please respect copyright.ＰＥＮＡＮＡ9MwltQ4mZH
610Please respect copyright.ＰＥＮＡＮＡQTj4Qj6n5w
610Please respect copyright.ＰＥＮＡＮＡtGrfLTVJzy
久而久之，便再也沒有足夠的NK cell抑制癌細胞的生長，而當潛伏在另一器官的癌細胞快速繁殖之時，這亦是轉移(Metastasis)被鑑定發生之時。610Please respect copyright.ＰＥＮＡＮＡSbRcu8eQgP
610Please respect copyright.ＰＥＮＡＮＡ62eBXXI7By
610Please respect copyright.ＰＥＮＡＮＡeq2IO7SSto
對此，研發藥物或療程確保NK cell長期處於足夠水平，或許是一道避免癌細胞發生轉移的大方向。610Please respect copyright.ＰＥＮＡＮＡfwtrb5DqGa
610Please respect copyright.ＰＥＮＡＮＡ5g5Z4JnEcN
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。610Please respect copyright.ＰＥＮＡＮＡEd2gPu6VXZ
610Please respect copyright.ＰＥＮＡＮＡFeYPmC5lBj
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc610Please respect copyright.ＰＥＮＡＮＡJnpWCX4GLn
610Please respect copyright.ＰＥＮＡＮＡq2tbbN65EG
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。610Please respect copyright.ＰＥＮＡＮＡm1v0DCzFxO
610Please respect copyright.ＰＥＮＡＮＡHFgDotQyXn
Link:610Please respect copyright.ＰＥＮＡＮＡzlJqaCybu8
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio610Please respect copyright.ＰＥＮＡＮＡsAl0coOEDj
610Please respect copyright.ＰＥＮＡＮＡJomaGcaRWA
610Please respect copyright.ＰＥＮＡＮＡwlvWUshhvR
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。610Please respect copyright.ＰＥＮＡＮＡaplti4fi8M
610Please respect copyright.ＰＥＮＡＮＡKZHp37KvzA
Ref1:https://www.nature.com/articles/s41586-021-03614-z610Please respect copyright.ＰＥＮＡＮＡYhqlBCZoot

ns3.17.141.114da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章