科普專欄–薯不揀單 - 三十秒科學–細胞自噬

當細胞裡頭出現多餘或者已受損毀的物質，又或者是細胞面臨營養不足的情況，細胞便會啟動名為自噬(Autophagy)的機制，依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪，供自己能量或物質所需。563Please respect copyright.ＰＥＮＡＮＡ6SVHqMA9fm
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早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。563Please respect copyright.ＰＥＮＡＮＡinnsC7qCrL
三十秒科學–癌細胞也會自肥？563Please respect copyright.ＰＥＮＡＮＡkJqASGcfyz
- 分享自 LIHKG 討論區563Please respect copyright.ＰＥＮＡＮＡOJMEgTRCsR
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(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質，使自己得以在困局下苟延殘喘。563Please respect copyright.ＰＥＮＡＮＡTxe071fhbN
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情形就如人們債務纏身而又沒有收入抵債的時候，只好變賣自己所持有的資產，化成現金抵償。563Please respect copyright.ＰＥＮＡＮＡsVYa7ThbpY
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由此可以想像，這是一道治標不治標的方法。563Please respect copyright.ＰＥＮＡＮＡ0HsfCQEkNL
當長期沒有營養流入細胞，而細胞再也沒有多餘物質進行自噬的時候，細胞便會啟動自行滅亡的機制。563Please respect copyright.ＰＥＮＡＮＡAhCS3u9bYP
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(圖3)如果催谷癌細胞不斷進行自噬作用的話，促使它們啟動自行滅亡的機制，那豈不是殺滅它們的一道妙計?563Please respect copyright.ＰＥＮＡＮＡKNN0Xmk55r
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很遺憾地，各款癌細胞對於自噬作用的依賴及抗性均有所不同，難以就此單一針對自噬作用來消滅癌細胞。563Please respect copyright.ＰＥＮＡＮＡZ1Taukgt65
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暫時較為統一的發現是，大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。563Please respect copyright.ＰＥＮＡＮＡWHVDmDfFE6
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在實驗室細胞模型及老鼠實驗中，若果對胰臟癌細胞使用抑制自噬作用的藥物，不但改變它們的新陳代謝，且可減慢癌細胞的生長速度，非常之有潛質成為對抗胰臟癌的其中一手段。563Please respect copyright.ＰＥＮＡＮＡoO2iBN1u6b
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。563Please respect copyright.ＰＥＮＡＮＡuHVavaJag2
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc563Please respect copyright.ＰＥＮＡＮＡblORYiyDBT
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。563Please respect copyright.ＰＥＮＡＮＡjvQ7dp2AQl
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Link:563Please respect copyright.ＰＥＮＡＮＡgwSSAfldDd
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio563Please respect copyright.ＰＥＮＡＮＡHmckMu1QMk
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。563Please respect copyright.ＰＥＮＡＮＡj2eIyftyYN
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Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/563Please respect copyright.ＰＥＮＡＮＡ1ef2WY3dsE
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long

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