近日有急凍雞翼及其他產品被測量出擁有武肺存在，但武肺能否在雞翼或其他食物上大量繁殖呢？1194Please respect copyright.ＰＥＮＡＮＡOdANs8SVjv
1194Please respect copyright.ＰＥＮＡＮＡwNTFG4AKFp
答案是，不可以。1194Please respect copyright.ＰＥＮＡＮＡ9NbY0cedSE
1194Please respect copyright.ＰＥＮＡＮＡWEkJ2YC3fP
武肺進行大量繁殖的話，必需要借助活生生的細胞幫忙，而其中先決的一步就是要進入細胞體內。1194Please respect copyright.ＰＥＮＡＮＡep9fdGfRHx
1194Please respect copyright.ＰＥＮＡＮＡXHZUijNE7w
武肺可否入侵細胞，基本上視乎可唔可以達成下列3個條件。1194Please respect copyright.ＰＥＮＡＮＡnuADcFnnFb
（圖1）1194Please respect copyright.ＰＥＮＡＮＡsnPMTbPzAi
1194Please respect copyright.ＰＥＮＡＮＡ9P207sGQGd
1194Please respect copyright.ＰＥＮＡＮＡC5p8Wx8O6b
1. S protein與細胞表面的ACE2觸碰。1194Please respect copyright.ＰＥＮＡＮＡCTfFgK3jsm
1194Please respect copyright.ＰＥＮＡＮＡc51BT8vmbS
2. 細胞表面ACE2與S protein的形狀吻合，亦即是「啱嘴形」。1194Please respect copyright.ＰＥＮＡＮＡLQfBnIywia
1194Please respect copyright.ＰＥＮＡＮＡ1KpofoDXz9
3. 細胞表面擁有TMPRSS2蛋白質，能夠對S protein進行切割。1194Please respect copyright.ＰＥＮＡＮＡRCZqBw2FWn
1194Please respect copyright.ＰＥＮＡＮＡTgT4BuVq3y
滿足3大條件後，病毒就有能力能夠入侵細胞。1194Please respect copyright.ＰＥＮＡＮＡtiU1ibAg38
當然，入侵細胞後還有很多因素決定武肺能否大量繁殖，但急凍雞翼連活生生的細胞也沒有，根本無可能可以大量繁殖。1194Please respect copyright.ＰＥＮＡＮＡqXYadOBETN
1194Please respect copyright.ＰＥＮＡＮＡW06swDCqm0
何謂S protein和ACE2，可到我之前所寫的文章溫故知新。1194Please respect copyright.ＰＥＮＡＮＡ4KqUV5TWE3
https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/issue/91194Please respect copyright.ＰＥＮＡＮＡLnoKgumIkB
1194Please respect copyright.ＰＥＮＡＮＡLXbeRNkUrv
1194Please respect copyright.ＰＥＮＡＮＡ14gxpZMruu
1194Please respect copyright.ＰＥＮＡＮＡdzXl3PKT9H
（圖2）1194Please respect copyright.ＰＥＮＡＮＡwVrBPHbjza
第二點所謂的「啱嘴型」，所指的就是ACE2的形狀能否與武肺的S protein形狀吻合，就好像砌Puzzle一樣，兩者不吻合的話就無法連結一起，勉強亦無幸福。1194Please respect copyright.ＰＥＮＡＮＡou88cDlLrS
1194Please respect copyright.ＰＥＮＡＮＡp2PxS5hGca
如圖中所見，正因為老鼠ACE2唔啱嘴型，所以武肺無法引致老鼠患上肺炎等病徵，袁教授等人因此亦改用啱嘴型的倉鼠作為武肺的動物實驗模型。1194Please respect copyright.ＰＥＮＡＮＡFo8xxHEYNK
1194Please respect copyright.ＰＥＮＡＮＡpPUeJsU25z
（Ref 1)有科學家嘗試將武肺打落豬、雞和鴨身上，最終無法在牠們的任何器官身上找到武肺，而且亦沒有出現任何病徵，因此斷定牠們並不會受到武肺感染。1194Please respect copyright.ＰＥＮＡＮＡPyzgjgD9OF
1194Please respect copyright.ＰＥＮＡＮＡteZnHsiKU1
1194Please respect copyright.ＰＥＮＡＮＡqiXZ8K4eYq
（圖3）1194Please respect copyright.ＰＥＮＡＮＡtoAqvJDxu2
關於第三點，肺(Lung)及腎臟(Kidney)同樣擁有一定數量的ACE2及TMPRSS2（Ref2)，因此將會成為武肺的主要針對對象。1194Please respect copyright.ＰＥＮＡＮＡPXdGJXjHo8
1194Please respect copyright.ＰＥＮＡＮＡSacMowbH0u
而心臟(Heart) 同樣擁有一定數量的ACE2，某程度亦解釋了為何武肺患者康復後會被發現心臟出現異樣。1194Please respect copyright.ＰＥＮＡＮＡQLSkexkkCr
1194Please respect copyright.ＰＥＮＡＮＡ9MuN4Kaf1m
1194Please respect copyright.ＰＥＮＡＮＡqsnXG7YmXV
而男性器官睪丸(Testis)，亦是ACE2數量較多的器官（圖中沒有列出），所以，嗯......1194Please respect copyright.ＰＥＮＡＮＡTzSw7RhxRy
1194Please respect copyright.ＰＥＮＡＮＡDGfiRW0sCh
1194Please respect copyright.ＰＥＮＡＮＡTtGrjSj62D
1194Please respect copyright.ＰＥＮＡＮＡSvQCrN4q5I
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1194Please respect copyright.ＰＥＮＡＮＡGGlQLLTLMq
1194Please respect copyright.ＰＥＮＡＮＡN0IdApHSwc
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1194Please respect copyright.ＰＥＮＡＮＡAtVf5fubfV
1194Please respect copyright.ＰＥＮＡＮＡIHL7C4C4qu
同時亦可以在Penana網站裡按「買一嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1194Please respect copyright.ＰＥＮＡＮＡ9UeaPfcaee
1194Please respect copyright.ＰＥＮＡＮＡaj3Q3ycbMK
Link:1194Please respect copyright.ＰＥＮＡＮＡvmdiRPBskD
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1194Please respect copyright.ＰＥＮＡＮＡvyOKosKwT9
1194Please respect copyright.ＰＥＮＡＮＡYp9OOInB8y
1194Please respect copyright.ＰＥＮＡＮＡshYMzZu4D3
有興趣接收科普資訊的話，歡迎follow IG: potatopigtongue。1194Please respect copyright.ＰＥＮＡＮＡw23Zz71UNl
1194Please respect copyright.ＰＥＮＡＮＡIGGzGkZNZr
1194Please respect copyright.ＰＥＮＡＮＡvRI6vamsZw
1194Please respect copyright.ＰＥＮＡＮＡDUnNzoxim2
1194Please respect copyright.ＰＥＮＡＮＡ0CIAyD5ran
1194Please respect copyright.ＰＥＮＡＮＡX7WMbqGJi7
Ref1:https://science.sciencemag.org/content/368/6494/10161194Please respect copyright.ＰＥＮＡＮＡTxfRzu4wU6
1194Please respect copyright.ＰＥＮＡＮＡMtQJ82z7yG
Ref2:https://www.sciencedirect.com/science/article/pii/S221323172030820X#fig11194Please respect copyright.ＰＥＮＡＮＡOsDIXVSZKu
1234 copyright protection1190ＰＥＮＡＮＡJdpcvy6vnA 尼

216.73.216.75