科普專欄–薯不揀單 - 三十秒科學–談生酮飲食作癌症輔助治療的可行性

癌細胞跟正常細胞一樣，就算處於停止生長的狀態，均需攝取營養維持細胞運作。483Please respect copyright.ＰＥＮＡＮＡxtKmofJqgI
483Please respect copyright.ＰＥＮＡＮＡYw9YY19q1F
483Please respect copyright.ＰＥＮＡＮＡRgr8q4eJtF
在這個基礎下，有不少主張提倡以生酮飲食(Ketogenic Diet)作為醫治癌症的輔助療法。483Please respect copyright.ＰＥＮＡＮＡVTofU87kE6
究竟這是「武肺乃由5G網路而起」之流，還是有其實質科學實據支持呢?483Please respect copyright.ＰＥＮＡＮＡDzo7BXPto8
483Please respect copyright.ＰＥＮＡＮＡgTM3RaPOLc
（圖2）有不少的癌細胞均出現與PI3K蛋白質有關的變異，促使到它們具備更強大的快速繁殖及抵禦進行自我滅亡機制特性。483Please respect copyright.ＰＥＮＡＮＡZb0GxV3uCu
483Please respect copyright.ＰＥＮＡＮＡTjif0tvYgr
483Please respect copyright.ＰＥＮＡＮＡIMTK1iMT9A
有見及此，科學家們攜手合作，研發出藥物針對已變異的PI3K蛋白質，並在2010年其間進行大量的人類臨床研究，對相應的癌症病人下藥。483Please respect copyright.ＰＥＮＡＮＡrWBqZtgr8t
483Please respect copyright.ＰＥＮＡＮＡgXt7UKwS7s
遺憾的是，結果非常參差，整體成效並不理想。483Please respect copyright.ＰＥＮＡＮＡe7H7AMlS8S
483Please respect copyright.ＰＥＮＡＮＡiYnWLsQhCM
（圖3）深入探討為何會失敗後，科學家發現藥物對人體產生了一道副作用，就是誘使肝臟產生糖份，使血糖上升。483Please respect copyright.ＰＥＮＡＮＡiBBxnrC6ee
483Please respect copyright.ＰＥＮＡＮＡ8QF9cCc9qv
483Please respect copyright.ＰＥＮＡＮＡWXoGWei9RH
胰臟因著血糖的上升而產生胰島素，而非常諷刺的是，胰島素是激勵PI3K蛋白質的物質。483Please respect copyright.ＰＥＮＡＮＡtJKcn5FMoM
483Please respect copyright.ＰＥＮＡＮＡA6Yco5HVuy
亦即是說，藥物副作用所產生的胰島素，抵消了藥物本來抑制PI3K的功用。483Please respect copyright.ＰＥＮＡＮＡLxKC9OQOn4
483Please respect copyright.ＰＥＮＡＮＡmbXguRGuS9
483Please respect copyright.ＰＥＮＡＮＡURlmLdFB8X
（圖4）基於生酮飲食能夠消耗肝臟的糖原，以及維持血液低胰島素水平，科學家嘗試利用生酮飲食來制衡藥物的副作用，並在老鼠模型上取得非常可觀的成果。483Please respect copyright.ＰＥＮＡＮＡex9CW2F3yo
483Please respect copyright.ＰＥＮＡＮＡ6Lh1r5C9MR
483Please respect copyright.ＰＥＮＡＮＡgBMbbEO15A
現在即將進行子宮內壁膜癌症患者的臨床測試，以生酮飲食再配上PI3K藥物，希望能夠取得理想的成果。483Please respect copyright.ＰＥＮＡＮＡYF4xDWqu8M
483Please respect copyright.ＰＥＮＡＮＡ94gD9erl8d
但有一點要注意的是，在某類型血癌及腦癌個案，生酮飲食反之然會鼓吹癌細胞加速生長，這很有可能是因為是某類別的癌細胞特別傾向吸收脂肪或酮體。483Please respect copyright.ＰＥＮＡＮＡf1JpVMELmg
483Please respect copyright.ＰＥＮＡＮＡ6ykRG8rqsX
換句話說，在尚未摸透自身所患的癌細胞其新陳代謝特性之前，胡亂採取生酮飲食將有機會引來反效果，間接為癌細胞提供有利生長的環境。483Please respect copyright.ＰＥＮＡＮＡWbZ0bviDzL
483Please respect copyright.ＰＥＮＡＮＡy6eNCWL078
483Please respect copyright.ＰＥＮＡＮＡMmvaUB3TFu
483Please respect copyright.ＰＥＮＡＮＡrXkSS7mM0b
483Please respect copyright.ＰＥＮＡＮＡIprMXVLFdx
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。483Please respect copyright.ＰＥＮＡＮＡmtFxRKmbf2
483Please respect copyright.ＰＥＮＡＮＡDkKtGKa733
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc483Please respect copyright.ＰＥＮＡＮＡRV6bCUqRi2
483Please respect copyright.ＰＥＮＡＮＡMZLhu21bXv
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。483Please respect copyright.ＰＥＮＡＮＡnyBvSbtFe8
483Please respect copyright.ＰＥＮＡＮＡn4Bpw0yLpP
Link:483Please respect copyright.ＰＥＮＡＮＡ4XcMAADLtO
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio483Please respect copyright.ＰＥＮＡＮＡlHbdneipFt
483Please respect copyright.ＰＥＮＡＮＡUbykAs9cXK
483Please respect copyright.ＰＥＮＡＮＡjee6xFT0zi
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。483Please respect copyright.ＰＥＮＡＮＡTV9yzlxgRy
483Please respect copyright.ＰＥＮＡＮＡJCccH8yZoM
Ref1:https://www.nature.com/articles/s41586-018-0343-4483Please respect copyright.ＰＥＮＡＮＡumxv1CAZy1
Ref2:https://science.sciencemag.org/content/372/6537/20483Please respect copyright.ＰＥＮＡＮＡUI9am8p6uI

ns216.73.216.100da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章