科普專欄–薯不揀單 - 三十秒科學–癌細胞裡頭的油脂粒

前列腺癌與正常前列腺細胞的其中一道不同之處，就是前列腺癌細胞裡頭含有豐盛的油脂粒(Lipid Droplet)。560Please respect copyright.ＰＥＮＡＮＡhtvkDCnpfP
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油脂粒為細胞儲存脂肪的一道地方，在不少癌症例如乳癌、腸癌及腦癌也能找得到數量充盛的油脂粒。560Please respect copyright.ＰＥＮＡＮＡp3tCEG0mnT
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（圖2）前列腺癌細胞油脂粒的主要成份，是名為Cholesteryl ester (CE)的物質，560Please respect copyright.ＰＥＮＡＮＡHJGO5Pkz0e
簡單來說可以看成為脂肪酸與膽固醇結合在一起的物質。560Please respect copyright.ＰＥＮＡＮＡVNS1GHBn4D
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（圖3）CE，亦即是前列腺癌細胞油脂粒的主要成份，是依靠細胞裡頭一隻名為ACAT的蛋白酶製作而成。560Please respect copyright.ＰＥＮＡＮＡaQMhmoLo9G
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利用抑壓ACAT的藥物不但之能夠將老鼠的前列腺腫瘤縮小，更對老鼠身體的其他器官及細胞並無做成任何大的影響。560Please respect copyright.ＰＥＮＡＮＡq7wVv8zNPP
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某部份的前列腺癌細胞可依靠抑壓雄激素來阻止其生長，但此方法並非絕對有效，某部份的前列腺癌細胞並不依賴雄激素亦能快速生長及轉移到骨頭等各身體部位。560Please respect copyright.ＰＥＮＡＮＡ7qVJ2DT9ng
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在這種情況下，針對前列腺癌細胞的油脂新陳代謝來抑壓其生長，未嘗不是一道可行的方向。560Please respect copyright.ＰＥＮＡＮＡLI6ITxzo4Z
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。560Please respect copyright.ＰＥＮＡＮＡof1BMcRv2p
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc560Please respect copyright.ＰＥＮＡＮＡIj0sIJ8HJG
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。560Please respect copyright.ＰＥＮＡＮＡ3A6FGO06xa
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Link:560Please respect copyright.ＰＥＮＡＮＡ2ifEFfn7OM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio560Please respect copyright.ＰＥＮＡＮＡkJneYn8SBJ
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基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。560Please respect copyright.ＰＥＮＡＮＡ4Yo8xPgmiD
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Ref1:https://pubmed.ncbi.nlm.nih.gov/24606897/560Please respect copyright.ＰＥＮＡＮＡW9j8Gg5kcg

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