科普專欄–薯不揀單 - 深入淺出–脫髮與免疫系統的關係

鬼剃頭又稱圓禿(alopecia areata)，相信是由免疫系統出現問題而成。624Please respect copyright.ＰＥＮＡＮＡjhh9o7rIlh
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審視圓禿病人的基因後，的而且確發現有不少病人均持有與免疫細胞在發展方面有關的基因變異。624Please respect copyright.ＰＥＮＡＮＡsoK2ab4XMn
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（圖2）有科學家透過研究（Ref2)，證實外表持有Jag1蛋白質的免疫系統細胞，與髮囊幹細胞表面的Notch1蛋白質觸碰後，便會觸發髮囊幹細胞再生，讓頭髮在皮膚上持續生長。624Please respect copyright.ＰＥＮＡＮＡ9DeK8FOk3p
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（圖3）另外亦有人體實驗研究（Ref1)，注射Interlukin2(激發某系列的免疫細胞)到圓禿病人後，六個月後可見明顯效果。624Please respect copyright.ＰＥＮＡＮＡTX2BQg1ME0
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（圖4）圖中為老鼠的髮囊切片，可見髮囊附近的確有免疫細胞聚居。624Please respect copyright.ＰＥＮＡＮＡBhTTUeMUkX
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集合多方證據來看，免疫系統與頭髮生長有著莫大的關係，針對免疫系統來治理脫髮或許會成為一道重要出路。624Please respect copyright.ＰＥＮＡＮＡ6PpqOVPcpf
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Ref1:https://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/jamadermatol.2014.504624Please respect copyright.ＰＥＮＡＮＡDx5Xcy9dB0
Ref2:https://www.cell.com/action/showPdf?pii=S0092-8674%2817%2930529-9624Please respect copyright.ＰＥＮＡＮＡLYsE1QTyV1