科普專欄–薯不揀單 - 深入淺出–皮膚傷口不留疤痕的研究

皮膚受傷的時候，大多數的情況下都會出現結焦情況，過一段時間後傷口便會縫合。1056Please respect copyright.ＰＥＮＡＮＡ6xAaTee8CU
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有時候，皮膚會留有疤痕，但又有一些情況下會不留痕跡般似的進行修復，就像沒有事發生過一樣。1056Please respect copyright.ＰＥＮＡＮＡwGyvNlZm8e
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究竟最終會否留有疤痕，是看幸運還是甚麼呢？1056Please respect copyright.ＰＥＮＡＮＡorok6ae7YY
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（圖2）近日，有科學家發表文章(Ref1)，對此作出了一個頗為完滿的解答。1056Please respect copyright.ＰＥＮＡＮＡrW73fdvmUV
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他們在老鼠耳仔上開一個細洞，然後再緊密觀察其康復情況。他們發現塗上會引起發炎作用的Imiquimod(IMQ)後，傷口會完美修復不留疤。1056Please respect copyright.ＰＥＮＡＮＡjoORRjIOBY
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而在缺乏TRPA1神經細胞的老鼠，就算塗上(IMQ)，傷口始終會留有疤痕，表示TRPA1神經細胞在皮膚的修復上顯然有著重要作用。1056Please respect copyright.ＰＥＮＡＮＡiI3NgY8Tpk
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（圖3）他們進行了一系列的實驗，最終找出了箇中機制，以下為最簡化版本。1056Please respect copyright.ＰＥＮＡＮＡNf299W5ymw
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1.傷口塗上IMQ後，將會引起發炎作用。1056Please respect copyright.ＰＥＮＡＮＡl9KicYaIZ2
2.發炎作用刺激TRPA1神經細胞。1056Please respect copyright.ＰＥＮＡＮＡV91rsfsqn3
3.免疫系統細胞（dermal dendritic cells、γδ T cells）被傳召前來。1056Please respect copyright.ＰＥＮＡＮＡDJtRIlNrVh
4.免疫系統細胞釋出相關物質（Interlunkin17、22、23）。1056Please respect copyright.ＰＥＮＡＮＡcHgeWO7FcL
5.一系列的過程發生過後，肌膚完美修復。1056Please respect copyright.ＰＥＮＡＮＡZFY7urFm2a
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此研究的結果針對於老鼠的皮膚癒合情況，未必能套用在人類身上，需要作出人體試驗才能廣泛證實此結果。1056Please respect copyright.ＰＥＮＡＮＡuKarRHinSe
另外，IMQ的塗用時機還需要進一步確認，何時觸發發炎作用才是適當的時機還需要一系列的測試。1056Please respect copyright.ＰＥＮＡＮＡos1cvx8ypv
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不過有一點非常重要的是，當人類皮膚受傷的時候，自身是不會主動觸動TRPA1神經細胞。1056Please respect copyright.ＰＥＮＡＮＡU9FYlfImyP
若然整個結果能套用在人類身上的話，那亦是代表我們日後可塗上適當的藥膏刺激皮膚下的TRPA1細胞，觸發一系列的過程使傷口以不留疤痕的方式完美癒合！1056Please respect copyright.ＰＥＮＡＮＡsywrsAhjiM
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1056Please respect copyright.ＰＥＮＡＮＡ4EAqBBOD7c
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1056Please respect copyright.ＰＥＮＡＮＡhFDpKdB4MC
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1056Please respect copyright.ＰＥＮＡＮＡAZBs3hLmNk
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Link:1056Please respect copyright.ＰＥＮＡＮＡAQdjR5ZgEh
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1056Please respect copyright.ＰＥＮＡＮＡV6vWoKFlEa
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最後亦請幫一幫忙簽署袁爸的白宮呈請，幫忙為香港出一份力。1056Please respect copyright.ＰＥＮＡＮＡOasw6zLKzR
https://petitions.whitehouse.gov/petition/support-hong-kong-restart-clean-2020-legislative-council-election-now1056Please respect copyright.ＰＥＮＡＮＡXDQ6PXuuzy
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。1056Please respect copyright.ＰＥＮＡＮＡv9dWIHpwCt
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Ref1:https://immunology.sciencemag.org/content/5/50/eaba5683

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