自六月起,22103個已在GISAID資料庫公開的武肺排組中,約有72%的樣本為D614G變異品種。1510Please respect copyright.PENANAGIH68ZONix
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D614G的意思為,原本排在第614個氨基酸由D(Aspartate)變異成為G(Glycine),而這個變異發生在武肺的S protein位置裡頭,正是現今不少疫苗公司針對武肺病毒製作疫苗的部位;1510Please respect copyright.PENANAznKt7KaWCu
1510Please respect copyright.PENANAoBl89QuSnx
原理是透過疫苗讓人體產生抗體,而其抗體辨認得到武肺S protein區域的話,便會對其進行殺滅。1510Please respect copyright.PENANAb8B4QIPKFZ
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近日有不少學術文章試圖解釋為何這變異品種(D614G)能夠成為沉默的大多數,但裡頭基於安全理由關係,大部份文章只能將部份的武肺病毒排組與其他病毒組合成為一隻新病毒再作研究,或者單獨抽取武肺部份區域進行實驗,從而推算武肺變種後所帶來的後果。1510Please respect copyright.PENANAjWPgqUvff8
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近日(2020年7月7日),終有一篇文章嘗試利用完整的武肺病毒試圖了解D614G變種的「威力」。1510Please respect copyright.PENANAJhE64WAJN1
Source: https://www.biorxiv.org/content/10.1101/2020.06.14.151357v2.supplementary-material#disqus_thread1510Please respect copyright.PENANA1nDPBGYY6K
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基於視覺畫面大過一切,我節錄了裡頭一幅實驗結果以作說明。1510Please respect copyright.PENANAlJaVoBpzdJ1510Please respect copyright.PENANA83wA8v0GJo
圖中的藍色區域為細胞,當被受武肺感染的話便會呈紅色。換句話說,紅點越多,亦即代表武肺成感染細胞的效率越高。1510Please respect copyright.PENANAZjbslKGEV6
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由左至右為細胞受病毒感染的時間(12、18及24小時),上行(Spike D614)為沒有變異的病毒,下行(Spike G614)為現時沉默的大多數D614G武肺變種。1510Please respect copyright.PENANAoFKnEqyAaY
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畫面清晰可見,D614G變種的感染效率對比未變種的為高。1510Please respect copyright.PENANAhOZwtvJec5
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令人略為擔憂的是,這D614G品種雖在2月初期出現,但直至後期4、5月左右才開始受到注目。1510Please respect copyright.PENANALbMyeTOmI3
1510Please respect copyright.PENANA7AojaBOvoa
現時美國疫苗公司Moderna及中國的Sino分別處於進行緊第三期臨床實驗及準備第三期臨床實驗的階段,相信將會是世界上頭兩間公司最快提供得到疫苗。1510Please respect copyright.PENANAFrSfWLB2BO
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兩間公司均是針對武肺S protein區域製造疫苗,他們的疫苗能否有對抗現今的武肺D614G變種,仍是未知之數。
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科普專欄–薯不揀單
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科普專欄–薯不揀單
Author:
薯仔聞茱莉

ISSUE #3
<<一圖解釋武肺最新變種(D614G)的威力>>
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