科普專欄–薯不揀單 - 三十秒科學–談生酮飲食作癌症輔助治療的可行性

癌細胞跟正常細胞一樣，就算處於停止生長的狀態，均需攝取營養維持細胞運作。531Please respect copyright.ＰＥＮＡＮＡIh0rYapG1P
531Please respect copyright.ＰＥＮＡＮＡbxCImtAYdh
531Please respect copyright.ＰＥＮＡＮＡcSwlDOSgH0
在這個基礎下，有不少主張提倡以生酮飲食(Ketogenic Diet)作為醫治癌症的輔助療法。531Please respect copyright.ＰＥＮＡＮＡAXiNx5smZz
究竟這是「武肺乃由5G網路而起」之流，還是有其實質科學實據支持呢?531Please respect copyright.ＰＥＮＡＮＡagAVM3a1ZX
531Please respect copyright.ＰＥＮＡＮＡbLuOPBAXPo
（圖2）有不少的癌細胞均出現與PI3K蛋白質有關的變異，促使到它們具備更強大的快速繁殖及抵禦進行自我滅亡機制特性。531Please respect copyright.ＰＥＮＡＮＡ3OF9uEMIvN
531Please respect copyright.ＰＥＮＡＮＡHRiGHCcFk1
531Please respect copyright.ＰＥＮＡＮＡhXVUyY48JB
有見及此，科學家們攜手合作，研發出藥物針對已變異的PI3K蛋白質，並在2010年其間進行大量的人類臨床研究，對相應的癌症病人下藥。531Please respect copyright.ＰＥＮＡＮＡXUixV05KuW
531Please respect copyright.ＰＥＮＡＮＡPJFM5bB93z
遺憾的是，結果非常參差，整體成效並不理想。531Please respect copyright.ＰＥＮＡＮＡfWBTVATt7y
531Please respect copyright.ＰＥＮＡＮＡbczERUPvjB
（圖3）深入探討為何會失敗後，科學家發現藥物對人體產生了一道副作用，就是誘使肝臟產生糖份，使血糖上升。531Please respect copyright.ＰＥＮＡＮＡ33eRz84Wbt
531Please respect copyright.ＰＥＮＡＮＡnV5efwkmNV
531Please respect copyright.ＰＥＮＡＮＡEa2yLPdYfu
胰臟因著血糖的上升而產生胰島素，而非常諷刺的是，胰島素是激勵PI3K蛋白質的物質。531Please respect copyright.ＰＥＮＡＮＡcraLu7qPAc
531Please respect copyright.ＰＥＮＡＮＡXVPbLOsZ3r
亦即是說，藥物副作用所產生的胰島素，抵消了藥物本來抑制PI3K的功用。531Please respect copyright.ＰＥＮＡＮＡJPxCQExRLp
531Please respect copyright.ＰＥＮＡＮＡseBAsdyG3P
531Please respect copyright.ＰＥＮＡＮＡOVkZTHTjtz
（圖4）基於生酮飲食能夠消耗肝臟的糖原，以及維持血液低胰島素水平，科學家嘗試利用生酮飲食來制衡藥物的副作用，並在老鼠模型上取得非常可觀的成果。531Please respect copyright.ＰＥＮＡＮＡ0OpqdbSjs8
531Please respect copyright.ＰＥＮＡＮＡCwCGo1I0Xd
531Please respect copyright.ＰＥＮＡＮＡ0f8fL0MqZI
現在即將進行子宮內壁膜癌症患者的臨床測試，以生酮飲食再配上PI3K藥物，希望能夠取得理想的成果。531Please respect copyright.ＰＥＮＡＮＡbwywKkmzYp
531Please respect copyright.ＰＥＮＡＮＡWbs8odFEwT
但有一點要注意的是，在某類型血癌及腦癌個案，生酮飲食反之然會鼓吹癌細胞加速生長，這很有可能是因為是某類別的癌細胞特別傾向吸收脂肪或酮體。531Please respect copyright.ＰＥＮＡＮＡlmuItxIlKG
531Please respect copyright.ＰＥＮＡＮＡx7vRKXU5jd
換句話說，在尚未摸透自身所患的癌細胞其新陳代謝特性之前，胡亂採取生酮飲食將有機會引來反效果，間接為癌細胞提供有利生長的環境。531Please respect copyright.ＰＥＮＡＮＡReoE0q5EZD
531Please respect copyright.ＰＥＮＡＮＡMGv3BnEmsW
531Please respect copyright.ＰＥＮＡＮＡQiPFueuXJ3
531Please respect copyright.ＰＥＮＡＮＡvirbRON6mJ
531Please respect copyright.ＰＥＮＡＮＡ0OENvdcd8A
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。531Please respect copyright.ＰＥＮＡＮＡtjCrzKlOQz
531Please respect copyright.ＰＥＮＡＮＡqjYuaGiNBF
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc531Please respect copyright.ＰＥＮＡＮＡf5xiB5xNk7
531Please respect copyright.ＰＥＮＡＮＡkNg9FP1LHn
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。531Please respect copyright.ＰＥＮＡＮＡYONYWkaf7h
531Please respect copyright.ＰＥＮＡＮＡhuFHUaORkK
Link:531Please respect copyright.ＰＥＮＡＮＡgTzFWTtRrY
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio531Please respect copyright.ＰＥＮＡＮＡkZcFMussJy
531Please respect copyright.ＰＥＮＡＮＡZb2htCI9xm
531Please respect copyright.ＰＥＮＡＮＡoxCvJYe6xZ
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。531Please respect copyright.ＰＥＮＡＮＡSrDAIUyWnV
531Please respect copyright.ＰＥＮＡＮＡ41WkqLbLae
Ref1:https://www.nature.com/articles/s41586-018-0343-4531Please respect copyright.ＰＥＮＡＮＡqawnhb1g1Q
Ref2:https://science.sciencemag.org/content/372/6537/20531Please respect copyright.ＰＥＮＡＮＡvDpOLNWJzJ

ns216.73.216.190da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章