上集略述了心臟肥大與心臟衰竭的關連,今集將會講述一道暫緩心臟由肥大演變成衰竭的研究。487Please respect copyright.PENANAO2QcZaucAu487Please respect copyright.PENANAf4IhN0THgf
487Please respect copyright.PENANALOCEk8KDgG
上集:https://lih.kg/gOrCdS487Please respect copyright.PENANAUGUiim2Mqs
487Please respect copyright.PENANA0x1CmnWQkF
(圖2)研究發現,當利用縫線手法引致心臟處於肥大狀態的時候,一隻名為GRK5的蛋白質會從心肌細胞的內部轉移到細胞核裡頭。487Please respect copyright.PENANA28Cvq4N8oR487Please respect copyright.PENANAKtczeVBXvh
487Please respect copyright.PENANAZSUvrQAEFt
487Please respect copyright.PENANA4WbSWjBSh0
(圖3)當GRK5進入細胞核後,它便會依靠圖中其紅色的部份與其他蛋白質(橙色)互動,因而改變其自身的形狀,發揮一系列的功效引致心臟肥大。487Please respect copyright.PENANA4L4aIYOnG1487Please respect copyright.PENANAHwJofOweJR
487Please respect copyright.PENANADWpOYP7xm1
見狀,科學家便特意單獨注入其紅色部份到細胞核,目的就是想透過紅色部份的霸佔,阻截完整的GRK5蛋白質與其他蛋白質(橙色)互動,使其功效喪失。487Please respect copyright.PENANAW4NQu6Ooha
487Please respect copyright.PENANAVq09QKFDsy
形象化來說,就是某勢力派人霸佔旁聽座位,讓其他人士無法入座。487Please respect copyright.PENANAFQNWnAR8pw
487Please respect copyright.PENANA1attisAnIQ
487Please respect copyright.PENANAN4FAQIVr6W
(圖4)縫線後所引起的心臟肥大,並沒有出現在注入紅色部份蛋白質的老鼠心臟裡頭。487Please respect copyright.PENANAjAKXT6dw82487Please respect copyright.PENANA14HecZHcGj
487Please respect copyright.PENANATWsQHiVZpo
最為重要的是,心臟肥大所引起的心肌纖維化(藍色箭嘴),並沒有能夠在注入紅色部份蛋白質的老鼠心臟裡頭找得到。487Please respect copyright.PENANAKyCAoKtuAU
487Please respect copyright.PENANAtBhM44hmAl
487Please respect copyright.PENANACgwoe2btLJ
換句話說,這GRK5的紅色部份,非常之有潛質可以發展成為抵抗血壓過高引致的心臟肥大藥物。487Please respect copyright.PENANAALVv94yPoh
487Please respect copyright.PENANABXxGuES0RX
487Please respect copyright.PENANAhHZenHcFxo
487Please respect copyright.PENANAx8vDRoB0oL
487Please respect copyright.PENANAVsUuQzCM1B
487Please respect copyright.PENANArvIFPRDEpZ
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。487Please respect copyright.PENANAB0oKxkvlQz
487Please respect copyright.PENANAlq04GcnhPg
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc487Please respect copyright.PENANAw47YE5bBoZ
487Please respect copyright.PENANAqj4MKqApRc
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。487Please respect copyright.PENANAraZCJDNbmD
487Please respect copyright.PENANAd95VZ0eOqM
Link:487Please respect copyright.PENANAggI4Csa6Qu
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio487Please respect copyright.PENANAa4SoQZ1Nyj
487Please respect copyright.PENANAbNsLJs0YqO
487Please respect copyright.PENANAoFjNuuz7uH
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。487Please respect copyright.PENANAqrpSyng8Ee
487Please respect copyright.PENANApWVLkymZeq
Ref1:https://stke.sciencemag.org/content/14/676/eabb5968487Please respect copyright.PENANAOGQ31kwbe8
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科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #194
三十秒科學–心臟肥大(2)
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