科普專欄–薯不揀單 - 三十秒科學–雙面人抗體

其中一道腫瘤形成的理論，就是經過無數基因異變的洗滌下，有助癌細胞生長的基因(Oncogene)不斷產生出來對它們有利的蛋白質，而負責抑制癌細胞生長的基因(Tumor Suppressor)則失去功用，沒能產生出制衝它們的蛋白質。582Please respect copyright.ＰＥＮＡＮＡEwKGUWcXIt
582Please respect copyright.ＰＥＮＡＮＡ94sbO61mAt
582Please respect copyright.ＰＥＮＡＮＡGkt40lqJ5F
在製藥角度來看，對付Oncogene常理上較為合理，畢竟抑制事物比起激發事物會來得更為容易。582Please respect copyright.ＰＥＮＡＮＡsA9nJiIhuN
582Please respect copyright.ＰＥＮＡＮＡ9HhVV7TXVQ
（圖2）P53蛋白質是其中一隻Tumor Suppressor，它最常見的變異版本就R175H，意思是它的第175個氨基酸發生了異變。582Please respect copyright.ＰＥＮＡＮＡoEW2v8D1QF
582Please respect copyright.ＰＥＮＡＮＡUqnyRAyEcy
582Please respect copyright.ＰＥＮＡＮＡA6aNPiJjli
P53蛋白質延伸閱讀:582Please respect copyright.ＰＥＮＡＮＡWm1RZnQMzM
分半鐘科學–缺氧對癌細胞的好處582Please respect copyright.ＰＥＮＡＮＡuAx8HdF8Mt
https://lih.kg/2420256582Please respect copyright.ＰＥＮＡＮＡi43p6oYcux
582Please respect copyright.ＰＥＮＡＮＡ5EZKWC5i19
雖然P53蛋白質主要是位於細胞內部，但當中會有一小節的蛋白質會表達在細胞表面上，名為新生抗原(Neoantigen)，數量極為稀少，可以少至1顆細胞只有10塊表達在其表面上。582Please respect copyright.ＰＥＮＡＮＡ5ISpvvBaHs
582Please respect copyright.ＰＥＮＡＮＡRoEkwy0l00
現時有科學家開始從針對Tumor Suppressor入手，製作出「雙面人」抗體(Bispecific antibodies)，一面辨認癌細胞的新生抗原，另一面則會辨認免疫細胞T cell，目的就是希望透過雙面人抗體拉近免疫細胞與癌細胞的距離，促使免疫細胞更有效率地對癌細胞進行皇天擊殺。582Please respect copyright.ＰＥＮＡＮＡX6Zax2mSSZ
582Please respect copyright.ＰＥＮＡＮＡ4Gt1eDNZhE
（圖3）對老鼠注射平均表面每顆平均只有2塊變種版本新生抗原的癌細胞，七日後可從螢光技術見得到腫瘤有著增大的趨勢。582Please respect copyright.ＰＥＮＡＮＡ7tctAFPUS9
582Please respect copyright.ＰＥＮＡＮＡ7sbKT6D7TN
582Please respect copyright.ＰＥＮＡＮＡyNxJtOE6Et
而注射能辨認P53蛋白質R175H變種的雙面人抗體後，腫瘤體積顯著有所減少。582Please respect copyright.ＰＥＮＡＮＡJCwYAPaCzW
582Please respect copyright.ＰＥＮＡＮＡqRQAzOeacw
這技術的好處是能夠針對殺滅擁有特定變異基因的癌細胞，但基於每顆癌細胞的變異位置及程度均有所不同，要活用這技術的話便必須要獲取該病人的癌細胞基因變異狀況。582Please respect copyright.ＰＥＮＡＮＡSZNsnGA9qk
582Please respect copyright.ＰＥＮＡＮＡcmZ8C2ak1J
螢光技術延伸閱讀:582Please respect copyright.ＰＥＮＡＮＡU1aYXWnrgd
三十秒科學–透視癌細胞582Please respect copyright.ＰＥＮＡＮＡLkMyYsQkUi
https://lih.kg/2408323582Please respect copyright.ＰＥＮＡＮＡjKaH1pJH6v
582Please respect copyright.ＰＥＮＡＮＡCX1EVfCDdi
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。582Please respect copyright.ＰＥＮＡＮＡ4TT9Lq5KWv
582Please respect copyright.ＰＥＮＡＮＡCyV0IDXXlQ
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc582Please respect copyright.ＰＥＮＡＮＡMcWW6PW5RY
582Please respect copyright.ＰＥＮＡＮＡDEiREXnV7A
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。582Please respect copyright.ＰＥＮＡＮＡebqbxa9zgV
582Please respect copyright.ＰＥＮＡＮＡwdXlikz9n5
Link:582Please respect copyright.ＰＥＮＡＮＡisUSvtqLQr
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio582Please respect copyright.ＰＥＮＡＮＡOlGz4dkkwr
582Please respect copyright.ＰＥＮＡＮＡUjUSFETJQ7
582Please respect copyright.ＰＥＮＡＮＡbyWavXO06s
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。582Please respect copyright.ＰＥＮＡＮＡnSddQjbuRr
582Please respect copyright.ＰＥＮＡＮＡPrDDt3nLG7
Ref1:https://science.sciencemag.org/content/early/2021/02/26/science.abc8697582Please respect copyright.ＰＥＮＡＮＡ91JQ26c5kl

ns216.73.216.8da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章