科普專欄–薯不揀單 - 三十秒科學–癌細胞裡頭的油脂粒

前列腺癌與正常前列腺細胞的其中一道不同之處，就是前列腺癌細胞裡頭含有豐盛的油脂粒(Lipid Droplet)。563Please respect copyright.ＰＥＮＡＮＡsa984JNmnY
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油脂粒為細胞儲存脂肪的一道地方，在不少癌症例如乳癌、腸癌及腦癌也能找得到數量充盛的油脂粒。563Please respect copyright.ＰＥＮＡＮＡhjbGFJ9nNw
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（圖2）前列腺癌細胞油脂粒的主要成份，是名為Cholesteryl ester (CE)的物質，563Please respect copyright.ＰＥＮＡＮＡ5rL4mM5kZx
簡單來說可以看成為脂肪酸與膽固醇結合在一起的物質。563Please respect copyright.ＰＥＮＡＮＡjFdqZe5LhP
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（圖3）CE，亦即是前列腺癌細胞油脂粒的主要成份，是依靠細胞裡頭一隻名為ACAT的蛋白酶製作而成。563Please respect copyright.ＰＥＮＡＮＡNADCSfOsG4
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利用抑壓ACAT的藥物不但之能夠將老鼠的前列腺腫瘤縮小，更對老鼠身體的其他器官及細胞並無做成任何大的影響。563Please respect copyright.ＰＥＮＡＮＡWMET6yTys1
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某部份的前列腺癌細胞可依靠抑壓雄激素來阻止其生長，但此方法並非絕對有效，某部份的前列腺癌細胞並不依賴雄激素亦能快速生長及轉移到骨頭等各身體部位。563Please respect copyright.ＰＥＮＡＮＡBrHPNFpKJy
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在這種情況下，針對前列腺癌細胞的油脂新陳代謝來抑壓其生長，未嘗不是一道可行的方向。563Please respect copyright.ＰＥＮＡＮＡrU6QsZyZ9f
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。563Please respect copyright.ＰＥＮＡＮＡMNlNQBu8z6
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc563Please respect copyright.ＰＥＮＡＮＡ2m5r9yvwfy
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。563Please respect copyright.ＰＥＮＡＮＡ70LNZbn3uA
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Link:563Please respect copyright.ＰＥＮＡＮＡGaOxHPcsxM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio563Please respect copyright.ＰＥＮＡＮＡvY6orXvdKU
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基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。563Please respect copyright.ＰＥＮＡＮＡn0Fx7xq4HI
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Ref1:https://pubmed.ncbi.nlm.nih.gov/24606897/563Please respect copyright.ＰＥＮＡＮＡsSpRT4Y2jy

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