前列腺癌與正常前列腺細胞的其中一道不同之處,就是前列腺癌細胞裡頭含有豐盛的油脂粒(Lipid Droplet)。725Please respect copyright.PENANAZYEyFw9yJf
725Please respect copyright.PENANAExk6lyH1zP
725Please respect copyright.PENANA6Fc73gOrgX
油脂粒為細胞儲存脂肪的一道地方,在不少癌症例如乳癌、腸癌及腦癌也能找得到數量充盛的油脂粒。725Please respect copyright.PENANAJ2PoYxOGSM
725Please respect copyright.PENANA4AZT3KxJPV
(圖2)前列腺癌細胞油脂粒的主要成份,是名為Cholesteryl ester (CE)的物質,725Please respect copyright.PENANAFcNuUf9N4U
簡單來說可以看成為脂肪酸與膽固醇結合在一起的物質。725Please respect copyright.PENANARq16ua30Fm
725Please respect copyright.PENANAtK9gNl1MyP
725Please respect copyright.PENANAH0Tb5ga3tJ
(圖3)CE,亦即是前列腺癌細胞油脂粒的主要成份,是依靠細胞裡頭一隻名為ACAT的蛋白酶製作而成。725Please respect copyright.PENANAtKtomFuFf7
725Please respect copyright.PENANAnrZUX0JhKA
725Please respect copyright.PENANAS4LkTFaTYK
利用抑壓ACAT的藥物不但之能夠將老鼠的前列腺腫瘤縮小,更對老鼠身體的其他器官及細胞並無做成任何大的影響。725Please respect copyright.PENANAfs3N0WzNPM
725Please respect copyright.PENANAcTAWrNilBq
某部份的前列腺癌細胞可依靠抑壓雄激素來阻止其生長,但此方法並非絕對有效,某部份的前列腺癌細胞並不依賴雄激素亦能快速生長及轉移到骨頭等各身體部位。725Please respect copyright.PENANAM9yV8Az7By
725Please respect copyright.PENANANwL0JyoFqq
在這種情況下,針對前列腺癌細胞的油脂新陳代謝來抑壓其生長,未嘗不是一道可行的方向。725Please respect copyright.PENANArmsc8Bx2eC
725Please respect copyright.PENANAytB9GFmNAh
725Please respect copyright.PENANAAZi1EnIks1
725Please respect copyright.PENANAmmpzESGtjP
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。725Please respect copyright.PENANAZXJRvgu49Z
725Please respect copyright.PENANADB33JVC0S9
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc725Please respect copyright.PENANAr4p2i5TEH7
725Please respect copyright.PENANAz0AuRrSZt9
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。725Please respect copyright.PENANA2nTPWvic5C
725Please respect copyright.PENANAAAY6CBRs53
Link:725Please respect copyright.PENANAIAZdyF9sjf
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio725Please respect copyright.PENANAcTsWSD42UT
725Please respect copyright.PENANAxu5aFwFKEe
725Please respect copyright.PENANAx2rDG3fYsA
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。725Please respect copyright.PENANAqQocjw6NY6
725Please respect copyright.PENANAAyH6H7FzdX
Ref1:https://pubmed.ncbi.nlm.nih.gov/24606897/725Please respect copyright.PENANAA6sc7ASHLE
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科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #155
三十秒科學–癌細胞裡頭的油脂粒
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