科普專欄–薯不揀單 - 三十秒科學–控制肌肉重量的一隻蛋白酶

肌肉大概佔據身體重量的40%。536Please respect copyright.ＰＥＮＡＮＡT35I6TnH7I
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踏入50歲後，平均每10年就會有15-30%的肌肉流失。536Please respect copyright.ＰＥＮＡＮＡ13DhrkETnt
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（圖2）研究(Ref1)顯示老人家的肌肉裡頭，一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。536Please respect copyright.ＰＥＮＡＮＡos5Ezp3riX
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。536Please respect copyright.ＰＥＮＡＮＡxFFAx94Inh
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(圖3）而人類老化所出現的現象，老鼠亦能同樣發現得到。536Please respect copyright.ＰＥＮＡＮＡzS5G1XOMYh
除肌肉外，年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。536Please respect copyright.ＰＥＮＡＮＡXSNCLGhuod
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話，肌肉重量亦會有所提升。536Please respect copyright.ＰＥＮＡＮＡblE2ihVZTx
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相反，若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話，肌肉重量亦會有所下降。536Please respect copyright.ＰＥＮＡＮＡbZbHam3p0T
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這道研究展示出，只需對一隻蛋白酶作出針對性的抑制，便能夠達到控制肌肉重量及結構的奇效。536Please respect copyright.ＰＥＮＡＮＡrZqcpdFIrc
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現時已有藥物可抑制15-PGDH，但對於人類肌肉影響的臨床研究則欠奉。536Please respect copyright.ＰＥＮＡＮＡFIWYYsztjW
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只不過的是，現今均普遍認為增加體內細胞NAD數量的話，便可舒緩甚至是扭轉細胞的老化現象。然而，15-PGDH卻需要NAD才能正常運作，這一方面所出現的矛盾則未能解釋得到。536Please respect copyright.ＰＥＮＡＮＡ21AwUHmms7
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。536Please respect copyright.ＰＥＮＡＮＡ4BrSPYqbGW
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc536Please respect copyright.ＰＥＮＡＮＡPuu4qqTPsf
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。536Please respect copyright.ＰＥＮＡＮＡCi2ik2NXZC
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Link:536Please respect copyright.ＰＥＮＡＮＡ9BzxzgPYSE
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio536Please respect copyright.ＰＥＮＡＮＡpXmQ8yZuoe
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基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。536Please respect copyright.ＰＥＮＡＮＡaIOG5AvBv7
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059536Please respect copyright.ＰＥＮＡＮＡBBo3gFMqCp

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