根據一篇尚未接受同行審查的文章(Ref1),Moderna及輝端疫苗兩者在人體所產生的抗體數量並無大分別,而且抗體所針對病毒的位置,亦跟自然感染武肺人士所產生的抗體相同。356Please respect copyright.PENANAf2FdYKvOAf
356Please respect copyright.PENANAj1zOVnShdG
注射兩者第二劑疫苗的3-14星期後,其抗體數量約與自然感染人士1.3個月後的數量接近。356Please respect copyright.PENANAnbRM4uSsjh
356Please respect copyright.PENANAE82JbcjnVW
奈何的是,疫苗所產生的抗體,其應對英國/南非變種的能力明顯有所銳弱。根據抗體種類的不同,有一些抗體應對變種病毒的能力至少被銳弱了十倍以上有多。356Please respect copyright.PENANA6aeyCatIOR
356Please respect copyright.PENANAYYiXJy1NtN
同時間,把武肺病毒與疫苗抗體共同培植的話,能生存下來的武肺病毒亦出現與英國及南非變種一樣的排序,變相逆向證明疫苗或自然感染未變種病毒人士的抗體沒能有效應對最新的南非/英國或旗下牽伸的各種變種。356Please respect copyright.PENANA0nLYQ1C7IN
356Please respect copyright.PENANAC3UVavaJV1
若然屬實,Moderna/輝端疫苗很有可能要更新第二代作出應對。356Please respect copyright.PENANAIeOe98mHD5
356Please respect copyright.PENANApN7Jby7Iz9
至於科興及國藥疫苗會否同屬一命運,則尚未清楚,但在理論層面上,滅活疫苗應對變種的可能性會較mRNA疫苗更高。356Please respect copyright.PENANAOoRvoNipDX
356Please respect copyright.PENANAnPP039cOHg
不過理論歸理論,一切尚需實驗證據確實。356Please respect copyright.PENANAFZnvB5Wznk
356Please respect copyright.PENANAr1jyAn3aEp
356Please respect copyright.PENANAJyW1ih4w1X
356Please respect copyright.PENANA4SYSpHw3SE
Ref1:https://www.biorxiv.org/content/10.1101/2021.01.15.426911v1.full.pdf356Please respect copyright.PENANAaM9ATBNlk3
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科普專欄–薯不揀單
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科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #141
Moderna及輝瑞疫苗對抗英國及南非的武肺變種能力
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