科普專欄–薯不揀單 - 深入淺出–關於非洲豬瘟病毒的一項研究

非洲豬瘟病毒最早在1921年肯亞的農場飼養豬隻被記錄，現時已傳遍亞洲、非洲、歐洲及大洋洲50多個國家。624Please respect copyright.ＰＥＮＡＮＡGHbkBOTA1X
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病毒主要攻擊的位置肝臟、腎臟等，豬隻的致命率可高達100%，而暫時沒有疫苗可預防病毒引發的症狀。624Please respect copyright.ＰＥＮＡＮＡeg6KZmL02A
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(圖2)家豬未被引入之前，非洲豬瘟病毒在大自然間主要經由蜱及非洲疣豬兩者互相傳播。624Please respect copyright.ＰＥＮＡＮＡuRauEucIQJ
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作為非洲豬瘟病毒天然宿主的非洲疣豬，就算被感染上高劇量的非洲豬瘟病毒，亦不會出現任何症狀。624Please respect copyright.ＰＥＮＡＮＡ5D7B0E3sFo
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那麼，為何家豬受感染後又會出現症狀呢?624Please respect copyright.ＰＥＮＡＮＡ8BiF2sEBEp
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(圖3)尋覓原因之際，有報告指出無菌環境長大的豬隻，較容易受到出現非洲豬瘟病毒引起的症狀(Ref1)。624Please respect copyright.ＰＥＮＡＮＡwr42kYRDWp
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而無菌環境長大及農場環境長大其中一種最大的分別，就是無菌環境長大的豬隻腸道上不含細菌。624Please respect copyright.ＰＥＮＡＮＡtZ1ZuHvALX
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(圖4)腸道細菌能夠協助宿主的免疫反應產生，基於這一點，科學嘗試將對於非洲疣豬的腸道細菌移植到家豬腸道裡頭(Ref2)。624Please respect copyright.ＰＥＮＡＮＡSiDlOArPOJ
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非洲疣豬的排泄物內含其所屬的腸道細菌，經處理過後，排泄物由食道經過導管送到豬隻腸道裡。624Please respect copyright.ＰＥＮＡＮＡrF9XwnfP2L
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研究發現，被移植腸道細菌的家豬與沒有進行移植的家豬相比，被受非洲豬瘟病毒感染後，症狀出現率大致相同。624Please respect copyright.ＰＥＮＡＮＡF5GcORqoOI
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但若果換成為弱化感染力的病毒，被移植腸道細菌的家豬出現的症狀明顯有所減輕。624Please respect copyright.ＰＥＮＡＮＡo04UuaOzAq
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只不過，文中作者強調利用糞便移植的手段並沒能將所有品種透徹地進行轉移。624Please respect copyright.ＰＥＮＡＮＡgZp3yNpJOM
如果能夠準確找出非洲疣豬腸道哪一種細菌品種對抵抗病毒有顯著功效，然後再作針對性的腸道細菌移植，或者亦有機會可以幫忙家豬對抗非洲豬瘟病毒。624Please respect copyright.ＰＥＮＡＮＡpUHU4Yu1Sl
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。624Please respect copyright.ＰＥＮＡＮＡ7j5tF4atKZ
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc624Please respect copyright.ＰＥＮＡＮＡdYsnFpxhtr
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。624Please respect copyright.ＰＥＮＡＮＡIawrPuhHBc
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio624Please respect copyright.ＰＥＮＡＮＡcgnu3TEnhv
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。624Please respect copyright.ＰＥＮＡＮＡmDFqmbmVRb
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Ref1:https://pubmed.ncbi.nlm.nih.gov/25210179/624Please respect copyright.ＰＥＮＡＮＡpIIl7me3jL
Ref2:https://www.nature.com/articles/s41598-020-74651-3624Please respect copyright.ＰＥＮＡＮＡxjz4ygwvs9

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