最為理想的檢測武漢肺炎方法，當然是要準確同快速兩者兼備，不需任何儀器家用便能做到為之更佳。570Please respect copyright.ＰＥＮＡＮＡQjGGbdZkH0
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現今最為標準的檢測方法RT-QPCR，但整個過程接近耗時2小時，而且亦需要實驗室PCR儀器及專業人士確認結果的可信性。570Please respect copyright.ＰＥＮＡＮＡCEuwDvJCwR
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較為快捷但並未全面通行的方法為RT-LAMP，整個過程約耗時30-50分鐘，可套用不同方法展示結果，最高靈敏度比RT-QPCR約低10倍。570Please respect copyright.ＰＥＮＡＮＡ3FHyE1YZXc
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整個過程受著需要在攝氏65度運行的限制，距離家用化仍擁有著些許的不便。570Please respect copyright.ＰＥＮＡＮＡrs0Ypre85C
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（圖2）最近有科學家研發一套名為SENSR的檢測方法（Ref1)，耗時約30-50分鐘，但全程只需在攝氏37度運行!570Please respect copyright.ＰＥＮＡＮＡZr5CzY5RAy
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他們嘗試利用最為準確的RT-QPCR方法作出對比，40個樣本之中，有39個達一致結果。570Please respect copyright.ＰＥＮＡＮＡCMWvAZD2hp
整個檢測方法主要包含四大組件，如圖中所示。570Please respect copyright.ＰＥＮＡＮＡQP02LKLpat
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（圖3）經過精心的設計，兩隻Probes會辨認武肺病毒RNA前後二段位置。570Please respect copyright.ＰＥＮＡＮＡLrphg1JvIN
兩隻Probes同時辨認成功後，名為SplintR ligase的蛋白質便會將兩隻Probes連成一起。570Please respect copyright.ＰＥＮＡＮＡL1pvyt0H8G
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（圖4）連成一起的Probe將會被T7 RNA polymerase 利用，生產出特殊結構的物質。570Please respect copyright.ＰＥＮＡＮＡ5992CLxe22
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這些特殊結構物質會Fluroescence Dye結合，發出螢光，而沒有與特殊結構物質結合的Fluroescence Dye則不會發出螢光。570Please respect copyright.ＰＥＮＡＮＡ7h533gO6fu
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（圖5）只要將病人口水及能夠打破病毒外層的化學物與檢測方法組件放在一起，在攝氏37度的環境下，半小時後便能憑著螢光強度獲取結果。570Please respect copyright.ＰＥＮＡＮＡdsUVfqGXAj
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沒有螢光，意指沒有武肺病毒的存在。570Please respect copyright.ＰＥＮＡＮＡpLEmXhGv5v
而螢光越強，則代表武肺病毒數量就越多。570Please respect copyright.ＰＥＮＡＮＡKKcBv7Zscy
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若然整套檢測方法能長久地與RT-QPCR的結果吻合的話，甚至能改良至更短時間完成的話，那些健康碼或健康護照的系統便完全成為被科技淘汰、多餘無用的產物。570Please respect copyright.ＰＥＮＡＮＡX1XjbKaAjK
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。570Please respect copyright.ＰＥＮＡＮＡ3QjuneCosr
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Ref1:https://www.nature.com/articles/s41551-020-00617-5.epdf?sharing_token=jyB1FrYxTMs2zz7531NEC9RgN0jAjWel9jnR3ZoTv0Oek8rnwPluVmxh8oas6RXA_yYuSqspJD8rPlYkIjcQAnYsXIpSHTS1rRw2pBOABq2RcPNywJhYXk5RtoOUasrjInaGxrHnZw-U2KJCVSypN2TLCfr8XdJlRq3q0or2Vs8%3D8964 copyright protection566ＰＥＮＡＮＡOfotWgblNX 維尼

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