科普專欄–薯不揀單 - 深入淺出–吸煙與肺癌的關係

吸煙會引致肺癌機率大幅度上升，究竟現今有沒有充分證據證明這句說話呢?525Please respect copyright.ＰＥＮＡＮＡZyvsDQ2Ol9
525Please respect copyright.ＰＥＮＡＮＡpTndaH268t
525Please respect copyright.ＰＥＮＡＮＡGGdrJ55LW9
（圖2）講述之前，我們快速了解一下癌症形成的概論。525Please respect copyright.ＰＥＮＡＮＡ2Nqu8Ya1nu
525Please respect copyright.ＰＥＮＡＮＡyzAEbaaIwx
正常的細胞，裡頭擁有一系列的機制控制生長速度，確保不會出現無止境繁殖的局面。525Please respect copyright.ＰＥＮＡＮＡhApGJKlQt5
而當正常細胞的DNA發生異變的時候，大致上會迎來四個結局。525Please respect copyright.ＰＥＮＡＮＡ7PE9GnIo0g
525Please respect copyright.ＰＥＮＡＮＡiC4AJLgMhg
通常情況下，細胞會立刻修復DNA的變異，使變異細胞回復成為正常細胞。525Please respect copyright.ＰＥＮＡＮＡAwJXwIsasu
若果DNA修復機制失效的話，免疫細胞會辨認變異細胞為外來之物，將其殲滅以免遺禍人間。525Please respect copyright.ＰＥＮＡＮＡEpsCSo0io9
525Please respect copyright.ＰＥＮＡＮＡ9mG8dIVQeZ
而如果修復DNA機制及免疫系統同時失效的話，便會有兩種可能性的發生。525Please respect copyright.ＰＥＮＡＮＡm5dm3WTwOB
525Please respect copyright.ＰＥＮＡＮＡtbprUf5lRW
假若異變DNA原本的工作是負責控制生長速度、而其變異導致自身功用失效的話，細胞便有機會不受控地自我繁殖，形成腫瘤。525Please respect copyright.ＰＥＮＡＮＡ5lSdTfOkFc
525Please respect copyright.ＰＥＮＡＮＡG9drVpINP3
而如果異變DNA對發展癌細胞方面沒有任何幫助的話，那細胞便不會發展成為癌細胞，繼續攜帶變異DNA以正常速度繁殖。525Please respect copyright.ＰＥＮＡＮＡZUTdRwjFzr
525Please respect copyright.ＰＥＮＡＮＡ49yGyAuBPS
總言而之，DNA發生變異是正常細發展成為癌細胞的第一步。525Please respect copyright.ＰＥＮＡＮＡid7HL38lLc
525Please respect copyright.ＰＥＮＡＮＡvIWNY3m40x
525Please respect copyright.ＰＥＮＡＮＡerG1bkJ2WG
525Please respect copyright.ＰＥＮＡＮＡta7FVzsGJS
（圖3）為探討吸煙對DNA變異的影響，有研究找來對應群組（3個兒童、4個非吸煙者、6個已戒煙人士、3個尚有食煙習慣的渣滓）作檢驗(Ref1)，分別抽取各人的氣管細胞，以逐個細胞的方式檢驗DNA，以作DNA變異程度的觀察之用。525Please respect copyright.ＰＥＮＡＮＡnqzF0AcEdT
525Please respect copyright.ＰＥＮＡＮＡQJzdpmz0Rj
525Please respect copyright.ＰＥＮＡＮＡRRaSo71d3E
（圖4）DNA的變異有幾種方式，如圖中所見，吸煙人士的DNA變異均比非吸煙者為多頻密。525Please respect copyright.ＰＥＮＡＮＡEdqAwNsq6N
525Please respect copyright.ＰＥＮＡＮＡDxab9B9gqF
525Please respect copyright.ＰＥＮＡＮＡeupqumqpOt
（圖5）而最為重要的是，吸煙人士的氣管細胞擁有更多已知會導致癌症出現的基因轉變，這一系列的資料均指出吸煙是會增加癌症出現的機會。525Please respect copyright.ＰＥＮＡＮＡfFnUPEWanG
525Please respect copyright.ＰＥＮＡＮＡuZuvRnyWfA
525Please respect copyright.ＰＥＮＡＮＡEZRBubJSMc
（圖6）當然，凡事也是有例外的！525Please respect copyright.ＰＥＮＡＮＡ2b3FAS7b4U
525Please respect copyright.ＰＥＮＡＮＡ9tEMpAt2el
525Please respect copyright.ＰＥＮＡＮＡmvIthHZWqo
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。525Please respect copyright.ＰＥＮＡＮＡvlrIFE23yo
525Please respect copyright.ＰＥＮＡＮＡ9ZWOwcbR3A
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc525Please respect copyright.ＰＥＮＡＮＡywuIrbN8V3
525Please respect copyright.ＰＥＮＡＮＡB5Al39N6ai
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。525Please respect copyright.ＰＥＮＡＮＡMoW3RKRoWu
525Please respect copyright.ＰＥＮＡＮＡqKfwa8yYfe
Link:525Please respect copyright.ＰＥＮＡＮＡUamACsVeoo
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio525Please respect copyright.ＰＥＮＡＮＡpcr5tPcAEg
525Please respect copyright.ＰＥＮＡＮＡ47ltdsS373
525Please respect copyright.ＰＥＮＡＮＡLzAoi3SWch
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。525Please respect copyright.ＰＥＮＡＮＡcbIoi2K7ny
525Please respect copyright.ＰＥＮＡＮＡ2Mg6IwPYel
525Please respect copyright.ＰＥＮＡＮＡ39HeoRPKng
525Please respect copyright.ＰＥＮＡＮＡBX1VH5KTrJ
Ref1:https://www.nature.com/articles/s41586-020-1961-1