抗生素是其中一種應付細菌或微生物的手段,以Virginiamycin M2(VM2)這抗生素為例,它能夠與細菌的核糖體(Ribosome)結合,從而抑制細菌的生長及繁殖。790Please respect copyright.PENANAdUvzojLID5790Please respect copyright.PENANAZiAfiY8MCR
790Please respect copyright.PENANAdQ0ADSa3KT
790Please respect copyright.PENANABiQIhk26e3
為應對抗生素的襲擊,細菌亦會發展出不同的機制作出制衡。同樣以VM2作為例子,細菌會生產一隻名為VatA酵素,能夠有效對VM2進行改造。790Please respect copyright.PENANAq1Upa9nVxu
790Please respect copyright.PENANADq4zvE8TfN
被改造的VM2再也無法合併及阻礙Ribosome功能,細菌亦得以繼續無阻繁殖,展示出抗藥性。790Please respect copyright.PENANARhfZyqJqhz
790Please respect copyright.PENANA3n60OHzu46
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(圖2)最近,有科學家應用名為Modular Synthesis的技術進行應對(Ref1)。790Please respect copyright.PENANApEqKw4WhQK
簡單來說,Modular Synthesis就把化學物當作是砌LEGO一樣,能夠任意在短時間內改組化學物的各個部位。790Please respect copyright.PENANAF3HXd5wfj1790Please respect copyright.PENANAVNl6sCoCuT
790Please respect copyright.PENANAguzW6duIsZ
如圖中所示,化學物各顏色部位均能轉變成其相應顏色的組件。790Please respect copyright.PENANAPQDoomFX1E
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790Please respect copyright.PENANAzaopVh3Quz
(圖3)經過一輪的驗證後,科學家發現細菌VatA酵素會在VM2某部位(C14)進行改造,但箇中過程將會與VM2另一個位置(C4)進行觸碰。790Please respect copyright.PENANA2mlxy4AfG5790Please respect copyright.PENANAVegtjLsrjw
790Please respect copyright.PENANASUfNCZkoL8
基於這點,科學家特意在C4部位裝上一大串臃腫的化學結構,促使細菌VatA酵素無法與VM2進行互動的同時,亦能確保人為改造的VM2能夠使細菌的Ribosome功能受阻。790Please respect copyright.PENANAuaNIUHIYd9
790Please respect copyright.PENANAGdypRnP2sF
當然,並不難想像細菌會隨著時間的增長發展出另一種新穎的應對方法,到時候科學家會否重用Modular Synthesis技倆應對,或者發展出一道一勞永逸的方法,就有待我們細心等候了。790Please respect copyright.PENANAGVd4ESKEJw
790Please respect copyright.PENANAAU64bPFuAJ
暫時來說,這場道高一尺、魔高一丈的遊戲,應該還要持續好一段的時間。790Please respect copyright.PENANAN0wcj73WNP
790Please respect copyright.PENANAexraC9WjoJ
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。790Please respect copyright.PENANASmhckEgci1
790Please respect copyright.PENANAPTBZ5jvg0e
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc790Please respect copyright.PENANAtWRW05W5B3
790Please respect copyright.PENANADkqOEkfJ4I
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。790Please respect copyright.PENANAOqkGrSi787
790Please respect copyright.PENANAhh1lUNxNu5
Link:790Please respect copyright.PENANAAGDKWsweBn
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio790Please respect copyright.PENANAfR6V7hrYSq
790Please respect copyright.PENANAmo1HlSKFuj
790Please respect copyright.PENANAolTA1D13rQ
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。790Please respect copyright.PENANA6fNGCqxO1M
790Please respect copyright.PENANAtNxpHt00l7
790Please respect copyright.PENANAwz3nFpVLxI
Ref1:https://www.nature.com/articles/s41586-020-2761-3790Please respect copyright.PENANApRKtRyI85K
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科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #59
深入淺出–抗生素為人類與細菌的戰場
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