抗生素是其中一種應付細菌或微生物的手段,以Virginiamycin M2(VM2)這抗生素為例,它能夠與細菌的核糖體(Ribosome)結合,從而抑制細菌的生長及繁殖。788Please respect copyright.PENANAi0WMmyZWjD788Please respect copyright.PENANAh5FBb32gUh
788Please respect copyright.PENANAtoLNEauRiD
788Please respect copyright.PENANAm1xippwJ8s
為應對抗生素的襲擊,細菌亦會發展出不同的機制作出制衡。同樣以VM2作為例子,細菌會生產一隻名為VatA酵素,能夠有效對VM2進行改造。788Please respect copyright.PENANAxKXu0xfSz0
788Please respect copyright.PENANAjsGx55PPlE
被改造的VM2再也無法合併及阻礙Ribosome功能,細菌亦得以繼續無阻繁殖,展示出抗藥性。788Please respect copyright.PENANAbVvfEMFavh
788Please respect copyright.PENANARg0rjp1JhL
788Please respect copyright.PENANAZx7oZ6VnNN
(圖2)最近,有科學家應用名為Modular Synthesis的技術進行應對(Ref1)。788Please respect copyright.PENANA2f0TuDU6g8
簡單來說,Modular Synthesis就把化學物當作是砌LEGO一樣,能夠任意在短時間內改組化學物的各個部位。788Please respect copyright.PENANAwwFdIglJt9788Please respect copyright.PENANAUzs9NGaZ4O
788Please respect copyright.PENANA5XI2wrKCHi
如圖中所示,化學物各顏色部位均能轉變成其相應顏色的組件。788Please respect copyright.PENANAiYLhIxxPOo
788Please respect copyright.PENANAleysPmzN43
788Please respect copyright.PENANA3UVzlcq70m
(圖3)經過一輪的驗證後,科學家發現細菌VatA酵素會在VM2某部位(C14)進行改造,但箇中過程將會與VM2另一個位置(C4)進行觸碰。788Please respect copyright.PENANA9bApYAB10c788Please respect copyright.PENANAgs3Hxx9LRr
788Please respect copyright.PENANAQPS85mMzQn
基於這點,科學家特意在C4部位裝上一大串臃腫的化學結構,促使細菌VatA酵素無法與VM2進行互動的同時,亦能確保人為改造的VM2能夠使細菌的Ribosome功能受阻。788Please respect copyright.PENANAfbzgkb1fKG
788Please respect copyright.PENANAZQbtvA3f92
當然,並不難想像細菌會隨著時間的增長發展出另一種新穎的應對方法,到時候科學家會否重用Modular Synthesis技倆應對,或者發展出一道一勞永逸的方法,就有待我們細心等候了。788Please respect copyright.PENANAPCOVKk9QPq
788Please respect copyright.PENANAQFkxsOWCXI
暫時來說,這場道高一尺、魔高一丈的遊戲,應該還要持續好一段的時間。788Please respect copyright.PENANAHAewjP8yAN
788Please respect copyright.PENANAE0HCfmoR4i
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。788Please respect copyright.PENANAxPtuuHRkhc
788Please respect copyright.PENANACUZ9fOAwTe
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc788Please respect copyright.PENANAhJIXc8JvRA
788Please respect copyright.PENANAN0Nrfk5Jdk
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。788Please respect copyright.PENANAm0nE9rabHH
788Please respect copyright.PENANAiCWxywuz23
Link:788Please respect copyright.PENANAvCpn2joVOT
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio788Please respect copyright.PENANAjdcDiyx0WZ
788Please respect copyright.PENANAelj6Z9L8UD
788Please respect copyright.PENANA9Gm6ZcAVeu
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。788Please respect copyright.PENANAA9ubfR3IuU
788Please respect copyright.PENANAEzi50ZNEdG
788Please respect copyright.PENANA1fXz9oZaqH
Ref1:https://www.nature.com/articles/s41586-020-2761-3788Please respect copyright.PENANAzjyk7eIjs3
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科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #59
深入淺出–抗生素為人類與細菌的戰場
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