抗生素是其中一種應付細菌或微生物的手段,以Virginiamycin M2(VM2)這抗生素為例,它能夠與細菌的核糖體(Ribosome)結合,從而抑制細菌的生長及繁殖。733Please respect copyright.PENANAl50r7oTzTl733Please respect copyright.PENANAwe6fXxBybJ
733Please respect copyright.PENANAqo0yPt5MWD
733Please respect copyright.PENANA1l4XYucpQg
為應對抗生素的襲擊,細菌亦會發展出不同的機制作出制衡。同樣以VM2作為例子,細菌會生產一隻名為VatA酵素,能夠有效對VM2進行改造。733Please respect copyright.PENANAkDvCried4u
733Please respect copyright.PENANAuiguqJ1So6
被改造的VM2再也無法合併及阻礙Ribosome功能,細菌亦得以繼續無阻繁殖,展示出抗藥性。733Please respect copyright.PENANAjrWBYLoXDZ
733Please respect copyright.PENANAeQnPtNZnkw
733Please respect copyright.PENANAEVpLlBxXgw
(圖2)最近,有科學家應用名為Modular Synthesis的技術進行應對(Ref1)。733Please respect copyright.PENANATvaY9ezIzO
簡單來說,Modular Synthesis就把化學物當作是砌LEGO一樣,能夠任意在短時間內改組化學物的各個部位。733Please respect copyright.PENANAeFBF4bgUIf733Please respect copyright.PENANAAB1QN3anwh
733Please respect copyright.PENANAdCn1bgEghL
如圖中所示,化學物各顏色部位均能轉變成其相應顏色的組件。733Please respect copyright.PENANAutORApGaC9
733Please respect copyright.PENANA7WehKairOF
733Please respect copyright.PENANA2vFYhEJWBF
(圖3)經過一輪的驗證後,科學家發現細菌VatA酵素會在VM2某部位(C14)進行改造,但箇中過程將會與VM2另一個位置(C4)進行觸碰。733Please respect copyright.PENANAIzlFqRAVD7733Please respect copyright.PENANAtwdB250iPQ
733Please respect copyright.PENANAhpkhH0XQPE
基於這點,科學家特意在C4部位裝上一大串臃腫的化學結構,促使細菌VatA酵素無法與VM2進行互動的同時,亦能確保人為改造的VM2能夠使細菌的Ribosome功能受阻。733Please respect copyright.PENANAetPjDWGMKE
733Please respect copyright.PENANA9utAjH0TDI
當然,並不難想像細菌會隨著時間的增長發展出另一種新穎的應對方法,到時候科學家會否重用Modular Synthesis技倆應對,或者發展出一道一勞永逸的方法,就有待我們細心等候了。733Please respect copyright.PENANAvSzSR7txsH
733Please respect copyright.PENANAy7qqDXVxb5
暫時來說,這場道高一尺、魔高一丈的遊戲,應該還要持續好一段的時間。733Please respect copyright.PENANARSXCCplFH0
733Please respect copyright.PENANASYtnuHXQLA
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。733Please respect copyright.PENANAVNYOoTV0pk
733Please respect copyright.PENANAt3YGKsKQG6
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc733Please respect copyright.PENANAmuogpoEHS5
733Please respect copyright.PENANARSUKnAQBnb
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。733Please respect copyright.PENANA84NYTJAhIM
733Please respect copyright.PENANAZvfz8A5Na7
Link:733Please respect copyright.PENANAmkjTNkHl0B
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio733Please respect copyright.PENANAeCl8VnRnFD
733Please respect copyright.PENANAPKSkQblAtb
733Please respect copyright.PENANAPQU0luQOqp
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。733Please respect copyright.PENANAanP4jQvLXo
733Please respect copyright.PENANAJ13lnFdxdv
733Please respect copyright.PENANA8aAqVFH8yQ
Ref1:https://www.nature.com/articles/s41586-020-2761-3733Please respect copyright.PENANA6qGfIdGHMs
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科普專欄–薯不揀單
Author:
薯仔聞茱莉

ISSUE #59
深入淺出–抗生素為人類與細菌的戰場
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