日照工作的時候,我們腦部的神經細胞會產生與神經退化症狀有關連的β-amyloid (Aβ)。509Please respect copyright.PENANAMEwnNEplJj
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在睡覺尤其是深層睡眠的時候,我們腦部的神經細胞會減少產生β-amyloid (Aβ)。同時間, β-amyloid (Aβ)會從腦脊髓液轉移到血液循環系統的靜脈,離開大腦。509Please respect copyright.PENANAcL63iekYVm
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夜間工作而日照時間睡覺會否達到同樣效果,暫時未有人體確實數據可以證實。509Please respect copyright.PENANAPCa3YBNjz5
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(圖2)睡覺時份,位於腦脊髓液(CSF)的β-amyloid (Aβ)透過星狀細胞(astrocyte)的協助,抵達靜脈排出腦外;509Please respect copyright.PENANAhn8FqXIypU
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另有研究指出(Ref1),部份的麻醉藥亦能促成同等效果。509Please respect copyright.PENANAY0kdLrJ0xK
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淋巴系統(Lymphatic System)是排除廢物的系統,基於排除Aβ需要透過星狀細胞的幫助,學術界把整套系統命名為Glympathic system,取其Glial Cell(神經膠質細胞)及Lymphatic System(淋巴系統)的結合,雖則整個機制並沒有淋巴系統的參與(Ref5)。509Please respect copyright.PENANAiUWjYOdcw3
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年老以及神經退化症狀的患者,Glympathic system效率大幅減低,因此引致大量β-amyloid (Aβ)聚積在腦部。而大量Aβ聚積在腦部的話,亦會影響睡眠的質素,形成惡性循環(Ref6)。509Please respect copyright.PENANAYJygOXQuZ8
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對比年輕人士,年老者的腦部Aβ水平平均高出17%。以同等年齡作比較的話,患有神經退化症人士的腦部Aβ水平則比健康人士平均高出31%。509Please respect copyright.PENANAwk3gbeGA2C
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(圖3)為作進一步了解睡覺與腦部Aβ水平的關係,有研究(Ref2)找來20名人士,分別嘗試進行連續31小時不准睡覺以及睡覺9小時兩種環境,繼而量度Aβ水平。509Please respect copyright.PENANAKodl03553Q
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兩種測驗環境之間,測試者平均相隔15日分別進行。結果得出,不論性別歲數,通宵一晚平均將會導致5%的Aβ上升。509Please respect copyright.PENANA2fym6dfs5n
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(圖4)另外,他們亦發現睡眠時數與Aβ的移除有著一定程度的正面關係。而另一研究(Ref3)找來了142名試驗者,發現睡眠質素越高的話,Aβ的移除比率亦會越大。509Please respect copyright.PENANAtsNRvvoboj
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只不過,亦有研究指出睡眠時數少於5小時或多於11的話,認知能力會有衰退傾向,但未知與Aβ是否有關。509Please respect copyright.PENANABbXd1rfYg2
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長遠而言,通宵會導致Aβ在腦部的聚積,增加患上神經退化症狀的機會,情況許可的話,可免就則免。509Please respect copyright.PENANAjGJ734CyUB
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。509Please respect copyright.PENANAAuL5yKPGgW
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc509Please respect copyright.PENANAcWT0aiRPT3
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。509Please respect copyright.PENANAQp1HlaWvv2
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Link:509Please respect copyright.PENANAyatG1EtlDu
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio509Please respect copyright.PENANA3YYZI3qjtQ
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。509Please respect copyright.PENANAvMGz6Mdmrl
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Ref1:https://advances.sciencemag.org/content/5/2/eaav5447509Please respect copyright.PENANAIMI0P6KBsV
Ref2:https://www.pnas.org/content/115/17/4483509Please respect copyright.PENANAkT6IZLj9e6
Ref3:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676720/509Please respect copyright.PENANAaV3H0Y1nR0
Ref4:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/509Please respect copyright.PENANAbEYyH0mM4h
Ref5:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/509Please respect copyright.PENANABYELObW3eO
Ref6:https://www.nature.com/articles/nrneurol.2013.269#ref-CR13
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科普專欄–薯不揀單
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科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #56
深入淺出–睡眠幫助大腦移除有害代謝物的機制
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