科普專欄–薯不揀單 - 深入淺出–皮膚傷口不留疤痕的研究

皮膚受傷的時候，大多數的情況下都會出現結焦情況，過一段時間後傷口便會縫合。948Please respect copyright.ＰＥＮＡＮＡnJba3wZaNq
948Please respect copyright.ＰＥＮＡＮＡseKpp387Dy
948Please respect copyright.ＰＥＮＡＮＡayDrFBCiw1
有時候，皮膚會留有疤痕，但又有一些情況下會不留痕跡般似的進行修復，就像沒有事發生過一樣。948Please respect copyright.ＰＥＮＡＮＡJjLpcbgjbp
948Please respect copyright.ＰＥＮＡＮＡRGBjoLBdkr
究竟最終會否留有疤痕，是看幸運還是甚麼呢？948Please respect copyright.ＰＥＮＡＮＡXUh1WP19yi
948Please respect copyright.ＰＥＮＡＮＡWi1A2fVx78
948Please respect copyright.ＰＥＮＡＮＡbCXOauwZbr
（圖2）近日，有科學家發表文章(Ref1)，對此作出了一個頗為完滿的解答。948Please respect copyright.ＰＥＮＡＮＡn6cFlKOaA9
948Please respect copyright.ＰＥＮＡＮＡ9o2HqhbekT
948Please respect copyright.ＰＥＮＡＮＡlpPI2X0Tdx
他們在老鼠耳仔上開一個細洞，然後再緊密觀察其康復情況。他們發現塗上會引起發炎作用的Imiquimod(IMQ)後，傷口會完美修復不留疤。948Please respect copyright.ＰＥＮＡＮＡLVgZAUFZv0
948Please respect copyright.ＰＥＮＡＮＡuQ73eUvfUm
而在缺乏TRPA1神經細胞的老鼠，就算塗上(IMQ)，傷口始終會留有疤痕，表示TRPA1神經細胞在皮膚的修復上顯然有著重要作用。948Please respect copyright.ＰＥＮＡＮＡKXkblw15qF
948Please respect copyright.ＰＥＮＡＮＡumaYMBS28X
（圖3）他們進行了一系列的實驗，最終找出了箇中機制，以下為最簡化版本。948Please respect copyright.ＰＥＮＡＮＡSYAraUsNtn
948Please respect copyright.ＰＥＮＡＮＡqJ47KqV2rg
948Please respect copyright.ＰＥＮＡＮＡcQipnE3jYW
1.傷口塗上IMQ後，將會引起發炎作用。948Please respect copyright.ＰＥＮＡＮＡnZh0bSGSLV
2.發炎作用刺激TRPA1神經細胞。948Please respect copyright.ＰＥＮＡＮＡZRH1hfShHp
3.免疫系統細胞（dermal dendritic cells、γδ T cells）被傳召前來。948Please respect copyright.ＰＥＮＡＮＡt87k6jMxoY
4.免疫系統細胞釋出相關物質（Interlunkin17、22、23）。948Please respect copyright.ＰＥＮＡＮＡLR9nWLj6Ps
5.一系列的過程發生過後，肌膚完美修復。948Please respect copyright.ＰＥＮＡＮＡi09L9Zqmr4
948Please respect copyright.ＰＥＮＡＮＡNjSKpZ1dEw
948Please respect copyright.ＰＥＮＡＮＡPU4fOp2HCQ
此研究的結果針對於老鼠的皮膚癒合情況，未必能套用在人類身上，需要作出人體試驗才能廣泛證實此結果。948Please respect copyright.ＰＥＮＡＮＡetHKEMzahB
另外，IMQ的塗用時機還需要進一步確認，何時觸發發炎作用才是適當的時機還需要一系列的測試。948Please respect copyright.ＰＥＮＡＮＡvvJMX0Tydf
948Please respect copyright.ＰＥＮＡＮＡ36Rb5zBPUj
不過有一點非常重要的是，當人類皮膚受傷的時候，自身是不會主動觸動TRPA1神經細胞。948Please respect copyright.ＰＥＮＡＮＡ1nhwuCy9xT
若然整個結果能套用在人類身上的話，那亦是代表我們日後可塗上適當的藥膏刺激皮膚下的TRPA1細胞，觸發一系列的過程使傷口以不留疤痕的方式完美癒合！948Please respect copyright.ＰＥＮＡＮＡVON06KGsyL
948Please respect copyright.ＰＥＮＡＮＡEUshOakHRn
948Please respect copyright.ＰＥＮＡＮＡozvs2CCQfe
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。948Please respect copyright.ＰＥＮＡＮＡJXtvO7wl2A
948Please respect copyright.ＰＥＮＡＮＡzyD6i609ZM
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc948Please respect copyright.ＰＥＮＡＮＡRm5titwTpp
948Please respect copyright.ＰＥＮＡＮＡQfmhauuuAf
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。948Please respect copyright.ＰＥＮＡＮＡocicxTvkF0
948Please respect copyright.ＰＥＮＡＮＡUyD5dLnywt
Link:948Please respect copyright.ＰＥＮＡＮＡwcAIUdbz34
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio948Please respect copyright.ＰＥＮＡＮＡVU7K9It3AR
948Please respect copyright.ＰＥＮＡＮＡwBY9IyEsXd
最後亦請幫一幫忙簽署袁爸的白宮呈請，幫忙為香港出一份力。948Please respect copyright.ＰＥＮＡＮＡgzb95IfAU6
https://petitions.whitehouse.gov/petition/support-hong-kong-restart-clean-2020-legislative-council-election-now948Please respect copyright.ＰＥＮＡＮＡppqqNNzRe6
948Please respect copyright.ＰＥＮＡＮＡZZUcpLPDXs
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。948Please respect copyright.ＰＥＮＡＮＡWgGiKCnNJh
948Please respect copyright.ＰＥＮＡＮＡeYmuSxDhz7
Ref1:https://immunology.sciencemag.org/content/5/50/eaba5683

ns3.144.115.82da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章