科普專欄–薯不揀單 - 深入淺出–皮膚傷口不留疤痕的研究

皮膚受傷的時候，大多數的情況下都會出現結焦情況，過一段時間後傷口便會縫合。993Please respect copyright.ＰＥＮＡＮＡU7Ue0tkJAr
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有時候，皮膚會留有疤痕，但又有一些情況下會不留痕跡般似的進行修復，就像沒有事發生過一樣。993Please respect copyright.ＰＥＮＡＮＡYsPL2r7wPo
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究竟最終會否留有疤痕，是看幸運還是甚麼呢？993Please respect copyright.ＰＥＮＡＮＡ0GZapd1ZRE
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（圖2）近日，有科學家發表文章(Ref1)，對此作出了一個頗為完滿的解答。993Please respect copyright.ＰＥＮＡＮＡxid2W0gJ8l
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他們在老鼠耳仔上開一個細洞，然後再緊密觀察其康復情況。他們發現塗上會引起發炎作用的Imiquimod(IMQ)後，傷口會完美修復不留疤。993Please respect copyright.ＰＥＮＡＮＡNBQHtJXcii
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而在缺乏TRPA1神經細胞的老鼠，就算塗上(IMQ)，傷口始終會留有疤痕，表示TRPA1神經細胞在皮膚的修復上顯然有著重要作用。993Please respect copyright.ＰＥＮＡＮＡkwoFIAcUfh
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（圖3）他們進行了一系列的實驗，最終找出了箇中機制，以下為最簡化版本。993Please respect copyright.ＰＥＮＡＮＡliqIQasROP
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1.傷口塗上IMQ後，將會引起發炎作用。993Please respect copyright.ＰＥＮＡＮＡEJUYM6HTJu
2.發炎作用刺激TRPA1神經細胞。993Please respect copyright.ＰＥＮＡＮＡ6I3CVlH9a1
3.免疫系統細胞（dermal dendritic cells、γδ T cells）被傳召前來。993Please respect copyright.ＰＥＮＡＮＡHoWGKQLmAq
4.免疫系統細胞釋出相關物質（Interlunkin17、22、23）。993Please respect copyright.ＰＥＮＡＮＡe6bg7BvKd9
5.一系列的過程發生過後，肌膚完美修復。993Please respect copyright.ＰＥＮＡＮＡcM8qd8JrPE
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此研究的結果針對於老鼠的皮膚癒合情況，未必能套用在人類身上，需要作出人體試驗才能廣泛證實此結果。993Please respect copyright.ＰＥＮＡＮＡotmgVPMKPH
另外，IMQ的塗用時機還需要進一步確認，何時觸發發炎作用才是適當的時機還需要一系列的測試。993Please respect copyright.ＰＥＮＡＮＡb5STXu312O
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不過有一點非常重要的是，當人類皮膚受傷的時候，自身是不會主動觸動TRPA1神經細胞。993Please respect copyright.ＰＥＮＡＮＡqZcKH9WUKY
若然整個結果能套用在人類身上的話，那亦是代表我們日後可塗上適當的藥膏刺激皮膚下的TRPA1細胞，觸發一系列的過程使傷口以不留疤痕的方式完美癒合！993Please respect copyright.ＰＥＮＡＮＡfT0E0vSge8
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。993Please respect copyright.ＰＥＮＡＮＡWpCQ5oZZLf
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc993Please respect copyright.ＰＥＮＡＮＡKVFIWsscgd
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。993Please respect copyright.ＰＥＮＡＮＡ5fza1BZRel
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio993Please respect copyright.ＰＥＮＡＮＡfi7R2b0oSS
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最後亦請幫一幫忙簽署袁爸的白宮呈請，幫忙為香港出一份力。993Please respect copyright.ＰＥＮＡＮＡ122P0Q4iPR
https://petitions.whitehouse.gov/petition/support-hong-kong-restart-clean-2020-legislative-council-election-now993Please respect copyright.ＰＥＮＡＮＡPfAduh2FY8
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。993Please respect copyright.ＰＥＮＡＮＡuARsWYh4eU
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Ref1:https://immunology.sciencemag.org/content/5/50/eaba5683

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