此篇文章並非意圖貶損任何癌症的治療方法,純粹是轉述一宗失敗個案及其原因,探討從失敗中學習的過程。299Please respect copyright.PENANAYe0aJGEP0b
299Please respect copyright.PENANAQyVtr6SCXy
利用免疫治療法來對抗癌症,早前我們已經花了不少篇幅講述。299Please respect copyright.PENANAZu4xFiPEyc
延伸閱讀:https://www.penana.com/article/500206299Please respect copyright.PENANAvykN0X9dKb
299Please respect copyright.PENANASWKLv2iVh3
299Please respect copyright.PENANAglAqThApfi
CAR T cell治療法,就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件,引導它們更有效率殲滅對應的細胞;299Please respect copyright.PENANA8RDACBFNwf
在這個層面上,亦即是癌細胞。299Please respect copyright.PENANAwB2AOkDKqT
299Please respect copyright.PENANATTslwxJ5Iv
(圖2)2010年,一名39歲女士患上腸癌,久經不同款式化療亦未見成效,故此便嘗試當時候較為新穎的CAR T cell 療法。299Please respect copyright.PENANAkBoztLJZ1I
299Please respect copyright.PENANAVTLX1OP0bD
299Please respect copyright.PENANAEfkpSveT8M
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質,所以其治療的方式便是從她身上取得免疫細胞,再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell,再以將這些CAR T cell注入她體內,盼望這些CAR T cell會殲滅腸癌細胞。299Please respect copyright.PENANAlYSWpKPDkO
299Please respect copyright.PENANAbWac9lcE81
299Please respect copyright.PENANAwUSJYtdELq
(圖3)不幸的是,注入CAR T cell後的15分鐘,她出現呼吸困難等症狀,隨之亦送入ICU作出治療,唯5日後亦與世祥辭。299Please respect copyright.PENANAG3NgAjX0T1
299Please respect copyright.PENANA3kSsV7wYyS
299Please respect copyright.PENANASTmHFHNlNm
最後經驗屍及分析各種數據後,相信是因為肺部含有微量ERBB2蛋白質,在抵達癌細胞位置前,那些CAR T cell率先與持有ERBB2的肺部細胞結合,產生過量的免疫反應,引致肺部器官發炎及衰竭,導致氧氣沒能輸送至各器官位置。299Please respect copyright.PENANATYe1xwQuj6
299Please respect copyright.PENANAfVBbKTEJKD
在這手術進行之前,亦有不少針對ERBB2的CAR T cell人體試驗,箇中並沒有發生相同症狀。299Please respect copyright.PENANAI2mU48d7eo
299Please respect copyright.PENANAZnseRpDjad
這相信是因為是次手術為了希望能夠順利殲滅癌細胞,其注入的T cell數量被以往實驗過多,因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。299Please respect copyright.PENANAEwkGBXarj8
299Please respect copyright.PENANAMMamRhMpsI
無論如何,從這之經驗中可得知,ERBB2顯然並不是一道針對癌細胞的理想對象。299Please respect copyright.PENANA0xpi1wgirb
299Please respect copyright.PENANAgb8y2WeOel
299Please respect copyright.PENANAZAYfoyxsJi
299Please respect copyright.PENANAAMO6ub0bzn
299Please respect copyright.PENANAONx9hMEklm
299Please respect copyright.PENANAyiNnsei66h
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。299Please respect copyright.PENANAFqmCLevf4l
299Please respect copyright.PENANAIMizzCMpkc
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc299Please respect copyright.PENANA0TN2wUP0k2
299Please respect copyright.PENANAhM2dDH6O1p
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。299Please respect copyright.PENANA4KsYZbvi9y
299Please respect copyright.PENANAhuV4NOExRU
Link:299Please respect copyright.PENANAu4cCaiZPOf
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio299Please respect copyright.PENANAqqOTtV9sV3
299Please respect copyright.PENANADuUeWvogv2
299Please respect copyright.PENANAhcAHCd0sIg
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。299Please respect copyright.PENANA2z6rCYOuMe
299Please respect copyright.PENANAxRstY3UZSb
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
299Please respect copyright.PENANAe8fkXCEaVI