科普專欄–薯不揀單 - 三十秒科學–痴肥對癌症腫瘤生長的影響

痴肥人士的患癌風險及死亡率均比健康人士為高。570Please respect copyright.ＰＥＮＡＮＡ7kZ0Fc3U9B
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位於癌細胞在所位置附近的肥肪細胞，相信亦有份協助癌細胞助大的進程。570Please respect copyright.ＰＥＮＡＮＡ9Ed81SCoQ5
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(圖2)從圖中的老鼠動物模型中可見，痴肥老鼠的腫瘤體積明顯比正常老鼠的為大。570Please respect copyright.ＰＥＮＡＮＡHWqR4hnygW
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痴肥老鼠的整體體重比正常老鼠的為重，雙方的肌肉重量並無太分別，唯痴肥老鼠的脂肪重量明顯比正常老鼠的為重。570Please respect copyright.ＰＥＮＡＮＡwn7Cb1wRPp
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(圖3)經過一系列的研究後，科學家發現脂肪細胞會供應Creatine給癌細胞，促進其生長。570Please respect copyright.ＰＥＮＡＮＡiwlRV1Uu99
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如果剔除脂肪細胞其中一隻負責製造Creatine的蛋白酶、或者剔除癌細胞表面負責攝取Creatine的蛋白酶，雖並不會對老鼠整體重量有大影響，但可以清楚得到痴肥老鼠腫瘤的縮細;570Please respect copyright.ＰＥＮＡＮＡinaoTSfqZD
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這效果只有在痴肥老鼠上才會出現，剔除相關的基因並沒有對健康老鼠的腫瘤體積有任何大影響。570Please respect copyright.ＰＥＮＡＮＡStlFWs8YOJ
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重要的是，就算在老鼠餐單上加入大量Creatine，亦不會對腫瘤重量有影響，這亦表明了只有癌細胞旁脂肪細胞所供應的本土Creatine才會對腫瘤的發展有正面影響。570Please respect copyright.ＰＥＮＡＮＡGHa4x8EgOD
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Ref1:https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00056-5570Please respect copyright.ＰＥＮＡＮＡWwurIc6RY4

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