科普專欄–薯不揀單 - 三十秒科學–頭髮幹細胞的三個階段

頭髮一直也是不少人所關注的議題，而頭髮的生長，實情跟幹細胞(Stem cell)息息相關。520Please respect copyright.ＰＥＮＡＮＡYOJKQkIhPb
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（圖2）頭髮的生長，是由位於髮囊底部名為hair-follicle stem cells (HFSCs)的幹細胞產生出來。520Please respect copyright.ＰＥＮＡＮＡqwJ4TIRk0f
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這些幹細胞會不斷地進行三個階段的循環，分別為anagen、catagen以及telogen。520Please respect copyright.ＰＥＮＡＮＡhF8Rs90svp
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（圖3）當anagen發生的時候，HFSCs幹細胞就會開始進行自我複製，經一系列的程序後便會導致毛髮生長;這階段可持續進行數年。520Please respect copyright.ＰＥＮＡＮＡbzGk9WIUXZ
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而當到達catagen的時候，毛髮便會停止生長，但依舊維持原位。520Please respect copyright.ＰＥＮＡＮＡwUZvc5xHsb
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之後便會進入telogan階段， HFSCs幹細胞進入「冬眠」狀態，不作任何複製舉動，而毛髮亦會因而自然地脫落。520Please respect copyright.ＰＥＮＡＮＡXfmIWZMWYY
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落入telogan階段後，幹細胞便會再度進入anagen階段，重新開始產生毛髮。520Please respect copyright.ＰＥＮＡＮＡUWsgpnlJHR
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健康人士的HFSCs幹細胞，高達80-90%處於anagen，10-20%處於catagan，只有1-5%處於telogan階段。520Please respect copyright.ＰＥＮＡＮＡ7RguzTZVn0
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由此可以推想出，脫髮或者禿頭的原因就是大多數的HFSCs處於catagan或telogan階段，並不再重返anagen階段。520Please respect copyright.ＰＥＮＡＮＡj8mLaF3t6h
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下集將會講解為何壓力過大會導致脫髮，箇中的原理涉及荷爾蒙的改變，及幹細胞三階段的失衡。520Please respect copyright.ＰＥＮＡＮＡGJ9dHjuT3l
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio520Please respect copyright.ＰＥＮＡＮＡmSvXktT4jk
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Ref1:https://pubmed.ncbi.nlm.nih.gov/26763421/520Please respect copyright.ＰＥＮＡＮＡ0euX9Sw4NC

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