科普專欄–薯不揀單 - 三十秒科學–痴肥導致糖尿病的其中一道論述

痴肥一直被譽為會增加患上糖尿病的機會。而箇中的理論，現今仍有著爭議的空間。536Please respect copyright.ＰＥＮＡＮＡstcsXuvsks
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本集將會討論眾多理論之中的其中一種，adipose tissue expandability hypothesis。536Please respect copyright.ＰＥＮＡＮＡTdKMSTCFUQ
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（圖2）Adipose tissue expandability hypothesis的理論就是，身體專責儲存脂肪的脂肪細胞不勝負荷，無法再繼續膨脹增大儲存脂肪。536Please respect copyright.ＰＥＮＡＮＡ0rWIL8NO2D
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正因如此，身體其他的細胞例如心臟細胞、肌肉細胞、胰臟細胞等亦唯有幫忙儲存脂肪。536Please respect copyright.ＰＥＮＡＮＡvqgx0NaPwM
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而這樣做的後果不但會損毀各種細胞的運作及功能，亦大大減低它們對胰島素的反應，導致血糖長期高企(糖尿病)。536Please respect copyright.ＰＥＮＡＮＡm1ZUGAwxwc
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（圖3）同時間，歲數增長亦是增加患上糖尿病的風險。536Please respect copyright.ＰＥＮＡＮＡwttUMrUiGu
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無獨有偶，處於45-65歲的癡肥患者，其真正專責儲存脂肪的脂肪細胞存量是比同齡健康人士少25%左右。536Please respect copyright.ＰＥＮＡＮＡs3kBxOII4M
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而天生因基因變異(PPARy, Sepin/ BCSL2, Lamin A和AKT2)而患上全身脂肪失養症的患者，脂肪細胞比例比正常人為少，其身體細胞出奇的更容易對胰島素不產生反應，導致更容易患上糖尿病。536Please respect copyright.ＰＥＮＡＮＡQv5H6Sd0hZ
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這兩點亦是Adipose tissue expandability hypothesis的重要支持理據。536Please respect copyright.ＰＥＮＡＮＡOaSVPWrQSa
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Ref1:https://www.sciencedirect.com/science/article/pii/S0308814620325899?via%3Dihub#t0010536Please respect copyright.ＰＥＮＡＮＡOURK1IxtUs

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