科普專欄–薯不揀單 - 三十秒科學–雙面人抗體

其中一道腫瘤形成的理論，就是經過無數基因異變的洗滌下，有助癌細胞生長的基因(Oncogene)不斷產生出來對它們有利的蛋白質，而負責抑制癌細胞生長的基因(Tumor Suppressor)則失去功用，沒能產生出制衝它們的蛋白質。571Please respect copyright.ＰＥＮＡＮＡbPcjIOpwGz
571Please respect copyright.ＰＥＮＡＮＡQ7XKdGyP61
571Please respect copyright.ＰＥＮＡＮＡSFnE1jmFUL
在製藥角度來看，對付Oncogene常理上較為合理，畢竟抑制事物比起激發事物會來得更為容易。571Please respect copyright.ＰＥＮＡＮＡmaPekxedzv
571Please respect copyright.ＰＥＮＡＮＡ5HhvTJTJnd
（圖2）P53蛋白質是其中一隻Tumor Suppressor，它最常見的變異版本就R175H，意思是它的第175個氨基酸發生了異變。571Please respect copyright.ＰＥＮＡＮＡS3r4T435Gd
571Please respect copyright.ＰＥＮＡＮＡZCwBcq8IdY
571Please respect copyright.ＰＥＮＡＮＡx5ms4VJXSb
P53蛋白質延伸閱讀:571Please respect copyright.ＰＥＮＡＮＡxvlMX9jWPi
分半鐘科學–缺氧對癌細胞的好處571Please respect copyright.ＰＥＮＡＮＡNFkgAuNFRH
https://lih.kg/2420256571Please respect copyright.ＰＥＮＡＮＡXByz3K9TxX
571Please respect copyright.ＰＥＮＡＮＡ60WBmHrsTQ
雖然P53蛋白質主要是位於細胞內部，但當中會有一小節的蛋白質會表達在細胞表面上，名為新生抗原(Neoantigen)，數量極為稀少，可以少至1顆細胞只有10塊表達在其表面上。571Please respect copyright.ＰＥＮＡＮＡHgy8aPrwVe
571Please respect copyright.ＰＥＮＡＮＡCjvAIvrs8L
現時有科學家開始從針對Tumor Suppressor入手，製作出「雙面人」抗體(Bispecific antibodies)，一面辨認癌細胞的新生抗原，另一面則會辨認免疫細胞T cell，目的就是希望透過雙面人抗體拉近免疫細胞與癌細胞的距離，促使免疫細胞更有效率地對癌細胞進行皇天擊殺。571Please respect copyright.ＰＥＮＡＮＡpdKNoRzG4b
571Please respect copyright.ＰＥＮＡＮＡ8QWUrMDpX3
（圖3）對老鼠注射平均表面每顆平均只有2塊變種版本新生抗原的癌細胞，七日後可從螢光技術見得到腫瘤有著增大的趨勢。571Please respect copyright.ＰＥＮＡＮＡFgxGEnq1DL
571Please respect copyright.ＰＥＮＡＮＡTzDKb97uUE
571Please respect copyright.ＰＥＮＡＮＡozkvK14dZC
而注射能辨認P53蛋白質R175H變種的雙面人抗體後，腫瘤體積顯著有所減少。571Please respect copyright.ＰＥＮＡＮＡ2FQF8ugVVN
571Please respect copyright.ＰＥＮＡＮＡmmGpIpJDMJ
這技術的好處是能夠針對殺滅擁有特定變異基因的癌細胞，但基於每顆癌細胞的變異位置及程度均有所不同，要活用這技術的話便必須要獲取該病人的癌細胞基因變異狀況。571Please respect copyright.ＰＥＮＡＮＡEsFXAgrZKR
571Please respect copyright.ＰＥＮＡＮＡJTUPlov88h
螢光技術延伸閱讀:571Please respect copyright.ＰＥＮＡＮＡWSmo08VOkc
三十秒科學–透視癌細胞571Please respect copyright.ＰＥＮＡＮＡ0lL7Lpahy5
https://lih.kg/2408323571Please respect copyright.ＰＥＮＡＮＡDePHk6YTPq
571Please respect copyright.ＰＥＮＡＮＡbojS1Mn4xy
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。571Please respect copyright.ＰＥＮＡＮＡLefYFznInb
571Please respect copyright.ＰＥＮＡＮＡDja5DUzAUP
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc571Please respect copyright.ＰＥＮＡＮＡuRGk2yAfx2
571Please respect copyright.ＰＥＮＡＮＡCfptm9ieIP
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。571Please respect copyright.ＰＥＮＡＮＡobp7mqwKVQ
571Please respect copyright.ＰＥＮＡＮＡunbdm1CHPJ
Link:571Please respect copyright.ＰＥＮＡＮＡWFTTU3BFzF
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio571Please respect copyright.ＰＥＮＡＮＡBwW1Loz0Vk
571Please respect copyright.ＰＥＮＡＮＡ5tRkafUo2d
571Please respect copyright.ＰＥＮＡＮＡRnBX9wuSZQ
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。571Please respect copyright.ＰＥＮＡＮＡiCRROMZlX7
571Please respect copyright.ＰＥＮＡＮＡgEfyu7Kv78
Ref1:https://science.sciencemag.org/content/early/2021/02/26/science.abc8697571Please respect copyright.ＰＥＮＡＮＡAqNYh1quc7

ns3.147.73.112da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章