科普專欄–薯不揀單 - 三十秒科學–癌細胞裡頭的油脂粒

前列腺癌與正常前列腺細胞的其中一道不同之處，就是前列腺癌細胞裡頭含有豐盛的油脂粒(Lipid Droplet)。460Please respect copyright.ＰＥＮＡＮＡvf4wKF1o1W
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油脂粒為細胞儲存脂肪的一道地方，在不少癌症例如乳癌、腸癌及腦癌也能找得到數量充盛的油脂粒。460Please respect copyright.ＰＥＮＡＮＡtbnH8xX26b
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（圖2）前列腺癌細胞油脂粒的主要成份，是名為Cholesteryl ester (CE)的物質，460Please respect copyright.ＰＥＮＡＮＡyGRIjLd0lu
簡單來說可以看成為脂肪酸與膽固醇結合在一起的物質。460Please respect copyright.ＰＥＮＡＮＡgp7PPsBBeF
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（圖3）CE，亦即是前列腺癌細胞油脂粒的主要成份，是依靠細胞裡頭一隻名為ACAT的蛋白酶製作而成。460Please respect copyright.ＰＥＮＡＮＡfA7ZTLp9jh
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利用抑壓ACAT的藥物不但之能夠將老鼠的前列腺腫瘤縮小，更對老鼠身體的其他器官及細胞並無做成任何大的影響。460Please respect copyright.ＰＥＮＡＮＡYNQtEzpaI6
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某部份的前列腺癌細胞可依靠抑壓雄激素來阻止其生長，但此方法並非絕對有效，某部份的前列腺癌細胞並不依賴雄激素亦能快速生長及轉移到骨頭等各身體部位。460Please respect copyright.ＰＥＮＡＮＡM8vLBZkZop
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在這種情況下，針對前列腺癌細胞的油脂新陳代謝來抑壓其生長，未嘗不是一道可行的方向。460Please respect copyright.ＰＥＮＡＮＡuHtYNDfM0Y
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。460Please respect copyright.ＰＥＮＡＮＡ5XPReMEExZ
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc460Please respect copyright.ＰＥＮＡＮＡfEW8ZAYzLo
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。460Please respect copyright.ＰＥＮＡＮＡVtBdFXT3SH
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio460Please respect copyright.ＰＥＮＡＮＡYgluqK7Wrn
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基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。460Please respect copyright.ＰＥＮＡＮＡ5wSBRUSSnD
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Ref1:https://pubmed.ncbi.nlm.nih.gov/24606897/460Please respect copyright.ＰＥＮＡＮＡwPjgQLoOuz

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